SYNE1 and GPX2

Data Source: HiPPIP (Novel)

		SYNE1	GPX2
Name		spectrin repeat containing nuclear envelope protein 1	glutathione peroxidase 2
Structure
GO Annotations	Cellular Component	P-body Nucleus Nuclear Envelope Nuclear Outer Membrane Nucleoplasm Nucleolus Cytoplasm Golgi Apparatus Cytoskeleton Membrane Sarcomere Nuclear Membrane Meiotic Nuclear Membrane Microtubule Tethering Complex Postsynaptic Membrane	Cytoplasm Cytosol Intercellular Bridge Mitotic Spindle
	Molecular Function	RNA Binding Actin Binding Protein Binding Lamin Binding Enzyme Binding Identical Protein Binding Protein Homodimerization Activity Actin Filament Binding Cytoskeleton-nuclear Membrane Anchor Activity	Peroxidase Activity Glutathione Peroxidase Activity Electron Transfer Activity Oxidoreductase Activity Phospholipid-hydroperoxide Glutathione Peroxidase Activity
	Biological Process	Nucleus Organization Golgi Organization Spermatogenesis Cell Differentiation Muscle Cell Differentiation Nuclear Matrix Anchoring At Nuclear Membrane	Response To Oxidative Stress Cellular Oxidant Detoxification
Pathways		Meiotic synapsis	Synthesis of 5-eicosatetraenoic acids Synthesis of 12-eicosatetraenoic acid derivatives Synthesis of 15-eicosatetraenoic acid derivatives Detoxification of Reactive Oxygen Species TP53 Regulates Metabolic Genes
Drugs		None	Glutathione Glutathione Glutathione disulfide Benzoyl peroxide
Diseases		Spinocerebellar ataxia (SCA); Machado-Joseph disease (SCA3) Emery-Dreifuss muscular dystrophy	None
GWAS		Appendicular lean mass ( 33097823 ) Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined) ( 23453885 ) Bipolar disorder ( 20351715 21738484 21926972 34002096 28072414 28115744 31043756 ) Bipolar disorder or major depressive disorder ( 20351715 ) Bipolar I disorder ( 31043756 ) Body mass index ( 26426971 ) Endometriosis ( 28537267 ) Femur bone mineral density x serum urate levels interaction ( 34046847 ) Heel bone mineral density ( 30598549 28869591 ) Hip circumference adjusted for BMI ( 34021172 ) Post bronchodilator FEV1 ( 26634245 ) Tonometry ( 17903302 ) Uterine fibroids ( 30194396 31249589 31649266 )	No GWAS studies recorded
Novel Interactors		11 novel interactors: AKAP12 GPX2 IL22RA2 IYD LATS1 NUP43 RAET1E RAET1L ULBP1 ULBP2 ZC3H12D	1 novel interactors: SYNE1
Interacting Genes		28 interacting genes: ACTC1 APC BDKRB2 BTG3 CAPN1 CDC42 CDC5L CEP63 DISC1 DSCAM DSCR9 DTNBP1 ECPAS EMD ITSN1 LINC00839 LMNA MTDH MUSK MYOM1 NDEL1 PCNT SH3BP5 TNIK TP53RK USP21 USP7 XIAP	3 interacting genes: MYC PSMB2 TP53
Entrez ID		23345	2877
HPRD ID		09762	11818
Ensembl ID		ENSG00000131018	ENSG00000176153
Uniprot IDs		A0A0C4DG40 B4E3R1 B7Z9Y6 F8WAI0 Q8NF91	P18283
PDB IDs		4DXR 6R15 6XF2	2HE3
GO Terms Enriched among Interactors		Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class I Via ER Pathway, TAP-independent Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class Ib Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class I Antigen Processing And Presentation Of Endogenous Antigen Natural Killer Cell Lectin-like Receptor Binding Positive Regulation Of T Cell Mediated Cytotoxicity Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I Regulation Of T Cell Mediated Cytotoxicity Signal Transduction Antigen Processing And Presentation Of Peptide Antigen Positive Regulation Of Leukocyte Mediated Cytotoxicity Regulation Of Postsynapse Organization Positive Regulation Of Cell Killing Positive Regulation Of T Cell Mediated Immunity Cytoskeleton Organization Regulation Of Synapse Organization Microtubule Organizing Center Molecular Adaptor Activity Regulation Of Leukocyte Mediated Cytotoxicity Radial Glia-guided Pyramidal Neuron Migration Antigen Processing And Presentation Centrosome Regulation Of T Cell Mediated Immunity Intracellular Signal Transduction Natural Killer Cell Mediated Cytotoxicity Negative Regulation Of Cell Cycle Natural Killer Cell Mediated Immunity Positive Regulation Of Plasma Membrane Bounded Cell Projection Assembly Positive Regulation Of Cell Projection Organization Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Positive Regulation Of Adaptive Immune Response Based On Somatic Recombination Of Immune Receptors Built From Immunoglobulin Superfamily Domains Leading Edge Membrane Positive Regulation Of Lymphocyte Mediated Immunity Glutamatergic Synapse Regulation Of Dendritic Spine Development Positive Regulation Of Adaptive Immune Response Negative Regulation Of Cyclin-dependent Protein Kinase Activity Cytoskeleton Neuron Projection Morphogenesis Cytosol Wnt Signaling Pathway Positive Regulation Of Pseudopodium Assembly Cell Projection Morphogenesis Regulation Of Plasma Membrane Bounded Cell Projection Organization Leukocyte Mediated Cytotoxicity Regulation Of Cell Projection Organization Positive Regulation Of Cellular Component Organization Regulation Of Wnt Signaling Pathway Cerebral Cortex Radially Oriented Cell Migration Regulation Of Protein Localization	Core Promoter Sequence-specific DNA Binding Positive Regulation Of Lymphocyte Apoptotic Process Lymphocyte Apoptotic Process Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Positive Regulation Of Leukocyte Apoptotic Process Negative Regulation Of Fibroblast Proliferation Regulation Of Lymphocyte Apoptotic Process Positive Regulation Of Intrinsic Apoptotic Signaling Pathway Cellular Response To Xenobiotic Stimulus Positive Regulation Of Transcription Initiation By RNA Polymerase II Positive Regulation Of MiRNA Metabolic Process Positive Regulation Of MiRNA Transcription Leukocyte Apoptotic Process T Cell Proliferation Positive Regulation Of DNA-templated Transcription Initiation Regulation Of MiRNA Transcription Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Regulation Of Transcription Initiation By RNA Polymerase II Regulation Of DNA-templated Transcription Initiation Cis-regulatory Region Sequence-specific DNA Binding Cellular Response To Light Stimulus Positive Regulation Of Metanephric Cap Mesenchymal Cell Proliferation Acinar Cell Proliferation Cellular Response To UV Regulation Of MiRNA Metabolic Process Muscle Cell Differentiation Regulation Of Fibroblast Proliferation Regulation Of Telomere Maintenance Positive Regulation Of Acinar Cell Proliferation SCF Ubiquitin Ligase Complex Binding Negative Regulation Of Helicase Activity Negative Regulation Of G1 To G0 Transition Lymphocyte Proliferation Mononuclear Cell Proliferation Regulation Of Signal Transduction By P53 Class Mediator Cellular Response To Hypoxia Cellular Response To Decreased Oxygen Levels Myc-Max Complex Positive Regulation Of Apoptotic Signaling Pathway Leukocyte Proliferation Regulation Of Acinar Cell Proliferation Oligodendrocyte Apoptotic Process Negative Regulation Of Pentose-phosphate Shunt Negative Regulation Of Glucose Catabolic Process To Lactate Via Pyruvate Response To UV Cellular Response To Oxygen Levels NK T Cell Proliferation Cellular Response To Radiation Intrinsic Apoptotic Signaling Pathway Nucleolus