MT-ND4 and CTCF

Number of citations of the paper that reports this interaction (PubMedID 24725430)
0

Data Source:
BioGRID (two hybrid)

		MT-ND4	CTCF
Description		NADH dehydrogenase subunit 4	CCCTC-binding factor
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GO Annotations	Cellular Component	Mitochondrion Mitochondrial Inner Membrane Membrane Respiratory Chain Complex I	Chromosome, Centromeric Region Condensed Chromosome Male Germ Cell Nucleus Nucleus Nucleoplasm Chromosome Nucleolus
	Molecular Function	NADH Dehydrogenase Activity NADH Dehydrogenase (ubiquinone) Activity Ubiquinone Binding	Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Cis-regulatory Region Sequence-specific DNA Binding Transcription Coregulator Binding DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA Binding Chromatin Binding DNA-binding Transcription Factor Activity Protein Binding Zinc Ion Binding Chromatin Insulator Sequence Binding Sequence-specific DNA Binding Metal Ion Binding Chromatin Loop Anchoring Activity Sequence-specific Double-stranded DNA Binding
	Biological Process	Response To Hypoxia In Utero Embryonic Development Mitochondrial Electron Transport, NADH To Ubiquinone Aerobic Respiration Electron Transport Coupled Proton Transport Cerebellum Development Mitochondrial Respiratory Chain Complex I Assembly Response To Nicotine ATP Synthesis Coupled Electron Transport Proton Motive Force-driven Mitochondrial ATP Synthesis Response To Ethanol	Negative Regulation Of Transcription By RNA Polymerase II In Utero Embryonic Development Chromatin Organization DNA Methylation-dependent Constitutive Heterochromatin Formation Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Mitochondrion Organization Chromosome Segregation Heart Development Negative Regulation Of Cell Population Proliferation Gene Expression Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Protein Localization To Chromosome Epigenetic Regulation Of Gene Expression Negative Regulation Of Gene Expression Via Chromosomal CpG Island Methylation Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Cardiac Muscle Cell Differentiation Cardiac Muscle Cell Development Regulation Of Centromeric Sister Chromatid Cohesion Protein Localization To Chromosome, Centromeric Region Genomic Imprinting Chromatin Looping
Pathways		Mitochondrial translation termination Respiratory electron transport Complex I biogenesis	Activation of anterior HOX genes in hindbrain development during early embryogenesis
Drugs		NADH
Diseases		Leber optic atrophy; Leber hereditary optic atrophy (LHON)
GWAS			Elevated fasting plasma glucose ( 30004843) Eosinophil percentage of white cells ( 32888494) HDL cholesterol ( 19060911) Hemoglobin levels ( 32327693) Refractive error ( 32231278)
Interacting Genes		7 interacting genes: ABHD16A APC ATM CTCF GRB2 LIG4 NKX3-1	20 interacting genes: CHD1L CHD7 CHD8 HMGB1 MT-ND4 PARP1 POLR2A RAD51 RALA RHOU RXRA SIN3A SMAD3 SMAD4 THRB TRAF2 TRB YBX1 ZMYM4 ZMYM6
Entrez ID		4538	10664
HPRD ID		08954	05005
Ensembl ID		ENSG00000198886	ENSG00000102974
Uniprot IDs		H9EC08 P03905	A0A2R8YFL0 P49711
PDB IDs		5XTC 5XTD 5XTH 5XTI	1X6H 2CT1 5K5H 5K5I 5K5J 5K5L 5KKQ 5T00 5T0U 5UND 5YEF 5YEG 5YEH 5YEL 6QNX 7W1M 8SSQ 8SSR 8SSS 8SST 8SSU
Enriched GO Terms of Interacting Partners?		DNA Damage Response Regulation Of Chromosome Organization Cellular Response To Ionizing Radiation Mitotic Spindle Assembly Checkpoint Signaling Negative Regulation Of Mitotic Metaphase/anaphase Transition Regulation Of Organelle Organization Response To X-ray Cellular Response To Radiation Response To Ionizing Radiation V(D)J Recombination Condensed Chromosome Negative Regulation Of Cell Population Proliferation Cellular Response To Stress Negative Regulation Of Mitotic Nuclear Division Cellular Developmental Process Regulation Of Cell Population Proliferation Somitogenesis Somatic Cell DNA Recombination Heart Development Segmentation Response To Gamma Radiation Double-strand Break Repair Via Nonhomologous End Joining Regulation Of Mitotic Sister Chromatid Separation Pattern Specification Process Negative Regulation Of Chromosome Organization Insulin Receptor Signaling Pathway Tissue Morphogenesis Regulation Of Cell Cycle Regulation Of Chromosome Separation Guanyl-nucleotide Exchange Factor Adaptor Activity Establishment Of Integrated Proviral Latency Positive Regulation Of Androgen Secretion MADS Box Domain Binding Chromatin Loop Anchoring Activity Positive Regulation Of Cellular Component Organization Response To Radiation Regulation Of Mitotic Metaphase/anaphase Transition Regulation Of Sister Chromatid Segregation Regulation Of Mitotic Cell Cycle Nucleoplasm Protein Localization To Chromosome Establishment Of RNA Localization To Telomere Establishment Of Protein-containing Complex Localization To Telomere Positive Regulation Of Organelle Organization Positive Regulation Of Chromosome Organization Positive Regulation Of Telomerase Catalytic Core Complex Assembly Grb2-EGFR Complex Establishment Of Viral Latency Dorsal Aorta Development Phosphatidylserine Catabolic Process	Chromatin Binding DNA Binding In Utero Embryonic Development Embryo Development Ending In Birth Or Egg Hatching Multicellular Organism Development Chordate Embryonic Development Transcription By RNA Polymerase II Nucleic Acid Metabolic Process Nucleobase-containing Compound Metabolic Process Double-stranded DNA Binding DNA-templated Transcription Negative Regulation Of Transcription By RNA Polymerase II ATP-dependent Chromatin Remodeler Activity Chromatin Negative Regulation Of RNA Metabolic Process RNA Metabolic Process RNA Polymerase II-specific DNA-binding Transcription Factor Binding Nucleoplasm Negative Regulation Of Nucleobase-containing Compound Metabolic Process R-SMAD Binding Positive Regulation Of Thyroid Hormone Receptor Signaling Pathway Nucleobase-containing Compound Biosynthetic Process Regulation Of Developmental Process Enzyme Binding Positive Regulation Of Transcription By RNA Polymerase II Transcription Regulator Complex Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Signal Transduction Involved In Regulation Of Gene Expression Positive Regulation Of SMAD Protein Signal Transduction Regulation Of Thyroid Hormone Receptor Signaling Pathway MRNA Transcription By RNA Polymerase II Ubiquitin Protein Ligase Binding SMAD Protein Complex Transcription Coactivator Binding Regulation Of Cell Communication Regulation Of Signaling Heteromeric SMAD Protein Complex Regulation Of Transforming Growth Factor Beta2 Production Macromolecule Metabolic Process Cellular Response To Oxygen-containing Compound Regulation Of Signal Transduction MRNA Transcription Cellular Response To Transforming Growth Factor Beta Stimulus Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Extracellular Matrix Assembly Cellular Response To Glucose Stimulus Atrioventricular Canal Development MRNA Metabolic Process Positive Regulation Of RNA Biosynthetic Process
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