MT-ND4

Description		NADH dehydrogenase subunit 4
Image
GO Annotations	Cellular Component	Mitochondrion Mitochondrial Inner Membrane Membrane Respiratory Chain Complex I
	Molecular Function	NADH Dehydrogenase Activity NADH Dehydrogenase (ubiquinone) Activity Ubiquinone Binding
	Biological Process	Response To Hypoxia In Utero Embryonic Development Mitochondrial Electron Transport, NADH To Ubiquinone Aerobic Respiration Electron Transport Coupled Proton Transport Cerebellum Development Mitochondrial Respiratory Chain Complex I Assembly Response To Nicotine ATP Synthesis Coupled Electron Transport Proton Motive Force-driven Mitochondrial ATP Synthesis Response To Ethanol
Pathways		Mitochondrial translation termination Respiratory electron transport Complex I biogenesis
Drugs		NADH
Diseases		Leber optic atrophy; Leber hereditary optic atrophy (LHON)
GWAS
Interacting Genes		7 interacting genes: ABHD16A APC ATM CTCF GRB2 LIG4 NKX3-1
Entrez ID		4538
HPRD ID		08954
Ensembl ID		ENSG00000198886
Uniprot IDs		H9EC08 P03905
PDB IDs		5XTC 5XTD 5XTH 5XTI
Enriched GO Terms of Interacting Partners?		DNA Damage Response Regulation Of Chromosome Organization Cellular Response To Ionizing Radiation Mitotic Spindle Assembly Checkpoint Signaling Negative Regulation Of Mitotic Metaphase/anaphase Transition Regulation Of Organelle Organization Response To X-ray Cellular Response To Radiation Response To Ionizing Radiation V(D)J Recombination Condensed Chromosome Negative Regulation Of Cell Population Proliferation Cellular Response To Stress Negative Regulation Of Mitotic Nuclear Division Cellular Developmental Process Regulation Of Cell Population Proliferation Somitogenesis Somatic Cell DNA Recombination Heart Development Segmentation Response To Gamma Radiation Double-strand Break Repair Via Nonhomologous End Joining Regulation Of Mitotic Sister Chromatid Separation Pattern Specification Process Negative Regulation Of Chromosome Organization Insulin Receptor Signaling Pathway Tissue Morphogenesis Regulation Of Cell Cycle Regulation Of Chromosome Separation Guanyl-nucleotide Exchange Factor Adaptor Activity Establishment Of Integrated Proviral Latency Positive Regulation Of Androgen Secretion MADS Box Domain Binding Chromatin Loop Anchoring Activity Positive Regulation Of Cellular Component Organization Response To Radiation Regulation Of Mitotic Metaphase/anaphase Transition Regulation Of Sister Chromatid Segregation Regulation Of Mitotic Cell Cycle Nucleoplasm Protein Localization To Chromosome Establishment Of RNA Localization To Telomere Establishment Of Protein-containing Complex Localization To Telomere Positive Regulation Of Organelle Organization Positive Regulation Of Chromosome Organization Positive Regulation Of Telomerase Catalytic Core Complex Assembly Grb2-EGFR Complex Establishment Of Viral Latency Dorsal Aorta Development Phosphatidylserine Catabolic Process
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