KCNMB1 and CLCA1

Number of citations of the paper that reports this interaction (PubMedID 11994272)
0

Data Source:
HPRD (in vivo)

		KCNMB1	CLCA1
Description		potassium calcium-activated channel subfamily M regulatory beta subunit 1	chloride channel accessory 1
Image		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Voltage-gated Potassium Channel Complex Membrane Synapse	Extracellular Region Plasma Membrane Microvillus Membrane Secretory Granule Zymogen Granule Membrane
	Molecular Function	Protein Binding Calcium-activated Potassium Channel Activity Potassium Channel Regulator Activity	Metalloendopeptidase Activity Intracellularly Calcium-gated Chloride Channel Activity Chloride Channel Activity Peptidase Activity Metallopeptidase Activity Hydrolase Activity Metal Ion Binding
	Biological Process	Detection Of Calcium Ion Monoatomic Ion Transport Potassium Ion Transport Chemical Synaptic Transmission Monoatomic Ion Transmembrane Transport Potassium Ion Transmembrane Transport	Proteolysis Monoatomic Ion Transport Calcium Ion Transport Chloride Transport Monoatomic Ion Transmembrane Transport Cellular Response To Hypoxia Chloride Transmembrane Transport
Pathways		Ca2+ activated K+ channels cGMP effects Sensory processing of sound by inner hair cells of the cochlea Acetylcholine inhibits contraction of outer hair cells	Stimuli-sensing channels
Drugs		Procaine Ritodrine Nitrendipine Miconazole Colforsin Trimebutine
Diseases
GWAS		Acne (severe) ( 24927181) Liver transplant-free survival in primary sclerosing cholangitis (time to event) ( 28779025)
Interacting Genes		5 interacting genes: CLCA1 EWSR1 KCNMA1 MT-CO1 STX8	2 interacting genes: ITGB4 KCNMB1
Entrez ID		3779	1179
HPRD ID		10358	04880
Ensembl ID		ENSG00000145936	ENSG00000016490
Uniprot IDs		Q16558	A8K7I4
PDB IDs			6PYO 6PYX
Enriched GO Terms of Interacting Partners?		Response To Decreased Oxygen Levels Response To Oxygen Levels Response To Hypoxia Large Conductance Calcium-activated Potassium Channel Activity Monoatomic Cation Transport Inorganic Ion Transmembrane Transport Monoatomic Ion Transmembrane Transport Response To Carbon Monoxide Smooth Muscle Contraction Involved In Micturition Micturition Monoatomic Ion Transport Negative Regulation Of Cell Volume Chloride Channel Inhibitor Activity Urinary Bladder Smooth Muscle Contraction Transmembrane Transport Calcium-activated Potassium Channel Activity Response To Metal Ion Cytochrome-c Oxidase Activity Intracellularly Calcium-gated Chloride Channel Activity Zymogen Granule Membrane Mitochondrial Electron Transport, Cytochrome C To Oxygen Intracellular Potassium Ion Homeostasis Respiratory Chain Complex IV Oxidative Phosphorylation Early Endosome To Late Endosome Transport	Hemidesmosome Assembly Hemidesmosome Skin Morphogenesis Myelin Assembly Cell Communication Nail Development Peripheral Nervous System Myelin Formation Insulin-like Growth Factor I Binding Neuregulin Binding Mesodermal Cell Differentiation Trophoblast Cell Migration Detection Of Calcium Ion Calcium-activated Potassium Channel Activity Myelination In Peripheral Nervous System Filopodium Assembly Integrin Complex Cell Adhesion Mediated By Integrin Cell-substrate Junction Organization Cell-substrate Junction Assembly Potassium Channel Regulator Activity Cell Leading Edge Basal Plasma Membrane G Protein-coupled Receptor Binding Voltage-gated Potassium Channel Complex Basement Membrane Myelination Axon Ensheathment Integrin-mediated Signaling Pathway Cell-matrix Adhesion Detection Of Chemical Stimulus Ameboidal-type Cell Migration Response To Calcium Ion
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