COX4I1 and COX1

Number of citations of the paper that reports this interaction (PMID 14607829)
28

Data Source:
HPRD (in vivo)

		COX4I1	COX1
Gene Name		cytochrome c oxidase subunit IV isoform 1	cytochrome c oxidase subunit I
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Mitochondrion Mitochondrial Inner Membrane Membrane Extracellular Vesicular Exosome
	Molecular Function	Cytochrome-c Oxidase Activity Protein Binding
	Biological Process	Generation Of Precursor Metabolites And Energy Response To Nutrient Respiratory Electron Transport Chain Cellular Metabolic Process Small Molecule Metabolic Process Transmembrane Transport Hydrogen Ion Transmembrane Transport
Pathways		Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. Respiratory electron transport The citric acid (TCA) cycle and respiratory electron transport Orphan transporters	Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. Respiratory electron transport The citric acid (TCA) cycle and respiratory electron transport Orphan transporters
Drugs
Diseases
GWAS		Thiazide-induced adverse metabolic effects in hypertensive patients ( 23400010)
Protein-Protein Interactions		3 interactors: APP COX1 SDCBP	9 interactors: CDC42 CLEC4G COX4I1 COX5A KCNMB1 LIG4 MEOX2 PRDX4 SNCA
Entrez ID		1327	4512
HPRD ID		00466	02469
Ensembl ID		ENSG00000131143
Uniprot IDs		P13073	P00395 Q7GXY8
PDB IDs
Enriched GO Terms of Interacting Partners?		Synaptic Growth At Neuromuscular Junction Collateral Sprouting In Absence Of Injury Positive Regulation Of Extracellular Vesicular Exosome Assembly Collateral Sprouting Axon Midline Choice Point Recognition Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Regulation Of Extracellular Vesicular Exosome Assembly Axon Choice Point Recognition Axon Guidance Response To Oxidative Stress Neuron Remodeling Positive Regulation Of Exosomal Secretion Regulation Of Exosomal Secretion Substrate-dependent Cell Migration, Cell Extension Axonogenesis Axon Development Cell Morphogenesis Involved In Neuron Differentiation Chemotaxis Cyclooxygenase Pathway Neuron Projection Morphogenesis Cellular Copper Ion Homeostasis Cell Morphogenesis Involved In Differentiation Prostaglandin Biosynthetic Process Copper Ion Homeostasis Suckling Behavior Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Positive Regulation Of Organelle Assembly Neuron Projection Development Neuron Maturation MRNA Polyadenylation Regulation Of Epidermal Growth Factor-activated Receptor Activity Prostaglandin Metabolic Process Cell Projection Morphogenesis Cell Part Morphogenesis Mating Behavior Endoplasmic Reticulum Calcium Ion Homeostasis RNA Polyadenylation Substrate-dependent Cell Migration Neuron Recognition Neuron Development Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Ionotropic Glutamate Receptor Signaling Pathway Regulation Of G2/M Transition Of Mitotic Cell Cycle Cell Morphogenesis Regulation Of Cell Cycle G2/M Phase Transition Icosanoid Biosynthetic Process Axon Cargo Transport Neuron Differentiation Mating Neuromuscular Junction Development	Respiratory Electron Transport Chain Electron Transport Chain Cellular Respiration Monovalent Inorganic Cation Transport Regulation Of Neuron Apoptotic Process Regulation Of Neuron Death Energy Derivation By Oxidation Of Organic Compounds Response To Metal Ion Neuron Death Generation Of Precursor Metabolites And Energy Positive Regulation Of Peptidyl-serine Phosphorylation Negative Regulation Of Thrombin Receptor Signaling Pathway Positive Regulation Of Hydrogen Peroxide Catabolic Process Positive Regulation Of Glutathione Peroxidase Activity Negative Regulation Of Male Germ Cell Proliferation DNA Ligation Involved In DNA Recombination Negative Regulation Of Dopamine Uptake Involved In Synaptic Transmission Negative Regulation Of Norepinephrine Uptake Cation Transport Response To Inorganic Substance Regulation Of Peptidyl-serine Phosphorylation Negative Regulation Of Mitochondrial Electron Transport, NADH To Ubiquinone Positive Regulation Of Hair Follicle Cell Proliferation Cellular Response To Metal Ion Negative Regulation Of Protein Complex Assembly Oxidation-reduction Process Regulation Of Protein Stability Cellular Response To Inorganic Substance Regulation Of Male Germ Cell Proliferation Negative Regulation Of Dopamine Metabolic Process Submandibular Salivary Gland Formation Dopamine Uptake Involved In Synaptic Transmission Negative Regulation Of Serotonin Uptake Actin Filament Branching Negative Regulation Of Cellular Respiration Regulation Of Microtubule Cytoskeleton Organization Negative Regulation Of Synaptic Transmission, Dopaminergic Negative Regulation Of Oxidative Phosphorylation Regulation Of Hair Follicle Cell Proliferation Positive Regulation Of Synapse Structural Plasticity Regulation Of Microtubule-based Process Negative Regulation Of Neuron Apoptotic Process Hydrogen Ion Transmembrane Transport Ion Transport Lagging Strand Elongation Pro-B Cell Differentiation Establishment Of Golgi Localization Response To Iron(II) Ion Cellular Response To Copper Ion Somite Specification
Tagcloud ?			adipogenic assessments cd105 cd73 cd90 chondrogenic derangement fetal galactosidase gdm gestation gestational huc immunoblotting intriguing jelly msc mscs nd2 nd9 osteogenic pgc programming senescence tfam uc umbilical underscore wharton
Tagcloud (Difference) ?			adipogenic assessments cd105 cd73 cd90 chondrogenic derangement fetal galactosidase gdm gestation gestational huc immunoblotting intriguing jelly msc mscs nd2 nd9 osteogenic pgc programming senescence tfam uc umbilical underscore wharton
Tagcloud (Intersection) ?