KLKB1 and F12

Number of citations of the paper that reports this interaction (PubMedID 3521732)
0

Data Source:
HPRD (in vitro)

		KLKB1	F12
Description		kallikrein B1	coagulation factor XII
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GO Annotations	Cellular Component	Extracellular Region Extracellular Space Plasma Membrane Extracellular Exosome	Extracellular Region Extracellular Space Rough Endoplasmic Reticulum Plasma Membrane Extracellular Matrix Extracellular Exosome
	Molecular Function	Serine-type Endopeptidase Activity Protein Binding Peptidase Activity Serine-type Peptidase Activity Hydrolase Activity	Serine-type Endopeptidase Activity Calcium Ion Binding Protein Binding Peptidase Activity Serine-type Peptidase Activity Hydrolase Activity Misfolded Protein Binding
	Biological Process	Factor XII Activation Proteolysis Inflammatory Response Blood Coagulation Hemostasis Zymogen Activation Plasminogen Activation Fibrinolysis Positive Regulation Of Fibrinolysis	Plasma Kallikrein-kinin Cascade Factor XII Activation Proteolysis Blood Coagulation Blood Coagulation, Intrinsic Pathway Hemostasis Positive Regulation Of Plasminogen Activation Protein Processing Protein Autoprocessing Positive Regulation Of Blood Coagulation Zymogen Activation Fibrinolysis Innate Immune Response Response To Misfolded Protein Positive Regulation Of Fibrinolysis
Pathways		Intrinsic Pathway of Fibrin Clot Formation Activation of Matrix Metalloproteinases Defective factor XII causes hereditary angioedema Defective SERPING1 causes hereditary angioedema	Intrinsic Pathway of Fibrin Clot Formation Defective factor XII causes hereditary angioedema Defective SERPING1 causes hereditary angioedema
Drugs		Zinc Ecallantide Human C1-esterase inhibitor Conestat alfa Gabexate Zinc acetate Zinc chloride Zinc sulfate, unspecified form Lanadelumab Berotralstat	Zinc Human C1-esterase inhibitor Ethanolamine oleate Conestat alfa Nafamostat Zinc acetate
Diseases		Fletcher factor deficiency; Prekallikrein deficiency	Hereditary angioedema Factor XII deficiency; Hageman factor deficiency
GWAS		Apolipoprotein A-IV levels ( 27412012) B-type natriuretic peptide levels ( 25561047) Cardiac troponin-I levels ( 31014085) Circulating chromogranin peptide levels ( 28011710) Circulating vasoactive peptide levels ( 23381795) Glycine levels ( 30837465) L-arginine levels ( 27656708) Metabolic traits ( 21886157) Metabolite levels ( 22916037 22286219) Obesity-related traits ( 23251661) Plasma renin activity levels ( 25477429) Response to statin therapy ( 20339536) Serum metabolite concentrations in chronic kidney disease ( 33838163) Serum metabolite levels ( 24625756 23093944 33031748) Venous thromboembolism ( 30659681)	Activated partial thromboplastin time ( 22703881 20303064 29403010) Cardiac troponin-I levels ( 31014085) Chronic kidney disease ( 20383146) Circulating chromogranin peptide levels ( 28011710) Circulating vasoactive peptide levels ( 23381795) Glycine levels ( 30837465) L-arginine levels ( 27656708) Metabolite levels ( 22286219 22916037) Nephrolithiasis ( 22396660) Platelet function and related traits ( 21546496) Serum metabolite levels ( 33031748) Tinnitus ( 33742053) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (age <50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		8 interacting genes: F12 HGF HGFAC IGFBP3 KNG1 MST1 SERPINA5 TFPI2	16 interacting genes: APOH APP CD93 EPAS1 GP1BA HIF1A KLKB1 KRT1 MMP12 MMP13 MMP14 UBE2D1 UBE2D2 UBE2D3 UBE2E1 UBE2N
Entrez ID		3818	2161
HPRD ID		01971	01992
Ensembl ID		ENSG00000164344	ENSG00000131187
Uniprot IDs		A8K9A9 B4DMX2 E9PBC5 P03952	P00748 Q8IZZ5
PDB IDs		2ANW 2ANY 4OGX 4OGY 5F8T 5F8X 5F8Z 5TJX 6I44 6O1G 6O1S 6T7P 7N7X 7QOX 8A3Q 8FGX	4BDW 4BDX 4XDE 4XE4 6B74 6B77 6GT6 6L63 6QF7 6SZW 6X0S 6X0T 7FBP 7PRJ 7PRK 8OS5 8R8D
Enriched GO Terms of Interacting Partners?		Extracellular Space Extracellular Region Coagulation Blood Coagulation Hemostasis Extracellular Matrix Regulation Of Body Fluid Levels Peptidase Inhibitor Activity Serine-type Endopeptidase Activity Rough Endoplasmic Reticulum Zymogen Activation Negative Regulation Of Blood Coagulation Negative Regulation Of Hemostasis Negative Regulation Of Coagulation Negative Regulation Of Wound Healing Regulation Of Hemostasis Regulation Of Blood Coagulation Platelet Alpha Granule Lumen Protein C Inhibitor-coagulation Factor V Complex Protein C Inhibitor-TMPRSS7 Complex Protein C Inhibitor-PLAU Complex Protein C Inhibitor-TMPRSS11E Complex Protein C Inhibitor-coagulation Factor Xa Complex Protein C Inhibitor-KLK3 Complex Protein C Inhibitor-plasma Kallikrein Complex Protein C Inhibitor-thrombin Complex Protein C Inhibitor-coagulation Factor XI Complex Protein C Inhibitor-PLAT Complex Serine-type Endopeptidase Inhibitor Activity Endopeptidase Activity Plasma Kallikrein-kinin Cascade Factor XII Activation Regulation Of Glucose Metabolic Process Seminal Clot Liquefaction Proteolysis Insulin-like Growth Factor Binding Protein Complex Platelet Dense Tubular Network Serine-type Peptidase Activity Regulation Of Wound Healing Positive Regulation Of Fibrinolysis Regulation Of Branching Involved In Salivary Gland Morphogenesis By Mesenchymal-epithelial Signaling Protein Tyrosine Phosphatase Activator Activity Insulin-like Growth Factor Ternary Complex Acrosin Binding Heparin Binding Regulation Of CAMP-dependent Protein Kinase Activity Regulation Of Response To Wounding Epithelial Cell Proliferation Protein Processing Regulation Of Protein Metabolic Process	Ubiquitin Conjugating Enzyme Activity Protein Metabolic Process Proteolysis Macromolecule Metabolic Process Negative Regulation Of Blood Coagulation Negative Regulation Of Hemostasis Negative Regulation Of Coagulation Collagen Metabolic Process Negative Regulation Of Wound Healing Regulation Of Hemostasis Regulation Of Blood Coagulation Fibrinolysis Protein K48-linked Ubiquitination Ubiquitin-protein Transferase Activity Regulation Of Body Fluid Levels Protein Polyubiquitination Zymogen Activation Regulation Of Wound Healing Collagen Catabolic Process Elastin Metabolic Process Serine-type Endopeptidase Activity Extracellular Matrix Disassembly Regulation Of Response To Wounding Hemopoiesis Protein Monoubiquitination Macromolecule Catabolic Process Blood Coagulation, Intrinsic Pathway Response To Amyloid-beta Intracellular Oxygen Homeostasis Plasminogen Activation Regulation Of Post-translational Protein Modification TOR Signaling Extracellular Matrix Organization Extracellular Structure Organization Tissue Remodeling Endopeptidase Activity Negative Regulation Of TOR Signaling Metalloendopeptidase Activity Regulation Of Fibrinolysis Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Protein Polyubiquitination Modification-dependent Protein Catabolic Process Catabolic Process Very-low-density Lipoprotein Particle Protein Activation Cascade Negative Regulation Of Signal Transduction Regulation Of Protein Neddylation Angiogenesis Protein Maturation Protein Ubiquitination
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