KLKB1 and F12

Number of citations of the paper that reports this interaction (PMID 3521732)
17

Data Source:
HPRD (in vitro)

		KLKB1	F12
Gene Name		kallikrein B, plasma (Fletcher factor) 1	coagulation factor XII (Hageman factor)
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space Plasma Membrane Extracellular Vesicular Exosome	Extracellular Region Extracellular Space Plasma Membrane Extracellular Vesicular Exosome
	Molecular Function	Serine-type Endopeptidase Activity Protein Binding	Serine-type Endopeptidase Activity Protein Binding Misfolded Protein Binding Serine-type Aminopeptidase Activity
	Biological Process	Factor XII Activation Proteolysis Blood Coagulation Blood Coagulation, Intrinsic Pathway Extracellular Matrix Disassembly Extracellular Matrix Organization Zymogen Activation Plasminogen Activation Fibrinolysis Positive Regulation Of Fibrinolysis	Plasma Kallikrein-kinin Cascade Factor XII Activation Proteolysis Blood Coagulation Blood Coagulation, Intrinsic Pathway Positive Regulation Of Plasminogen Activation Protein Processing Protein Autoprocessing Positive Regulation Of Blood Coagulation Zymogen Activation Fibrinolysis Innate Immune Response Response To Misfolded Protein Positive Regulation Of Fibrinolysis
Pathways		Intrinsic Pathway Activation of Matrix Metalloproteinases Degradation of the extracellular matrix Formation of Fibrin Clot (Clotting Cascade)	Intrinsic Pathway Formation of Fibrin Clot (Clotting Cascade)
Drugs
Diseases
GWAS		Circulating vasoactive peptide levels ( 23381795) Metabolic traits ( 21886157) Metabolite levels ( 22286219 22916037) Obesity-related traits ( 23251661) Response to statin therapy ( 20339536)	Activated partial thromboplastin time ( 22703881 20303064) Chronic kidney disease ( 20383146) Circulating vasoactive peptide levels ( 23381795) Metabolite levels ( 22286219 22916037) Nephrolithiasis ( 22396660) Platelet function and related traits ( 21546496)
Protein-Protein Interactions		8 interactors: F12 HGF HGFAC IGFBP3 KNG1 MST1 SERPINA5 TFPI2	15 interactors: APOH APP CD93 EPAS1 GP1BA KLKB1 KRT1 MMP12 MMP13 MMP14 UBE2D1 UBE2D2 UBE2D3 UBE2E1 UBE2N
Entrez ID		3818	2161
HPRD ID		01971	01992
Ensembl ID		ENSG00000164344	ENSG00000131187
Uniprot IDs		P03952	P00748 Q8IZZ5
PDB IDs		2ANW 2ANY	4BDW 4BDX
Enriched GO Terms of Interacting Partners?		Regulation Of Protein Processing Blood Coagulation Hemostasis Regulation Of Protein Metabolic Process Regulation Of Body Fluid Levels Wound Healing Negative Regulation Of Endopeptidase Activity Negative Regulation Of Peptidase Activity Response To Wounding Negative Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Proteolysis Negative Regulation Of Protein Processing Negative Regulation Of Protein Metabolic Process Regulation Of Endopeptidase Activity Negative Regulation Of Hydrolase Activity Regulation Of Peptidase Activity Regulation Of Cellular Protein Metabolic Process Blood Coagulation, Intrinsic Pathway Regulation Of Catalytic Activity Regulation Of Proteolysis Negative Regulation Of Catalytic Activity Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Negative Regulation Of Blood Coagulation Negative Regulation Of Coagulation Negative Regulation Of Wound Healing Negative Regulation Of Cellular Metabolic Process Platelet Degranulation Regulation Of Blood Coagulation Factor XII Activation Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Regulation Of Apoptotic Process Regulation Of Wound Healing Positive Regulation Of Cell Death Regulation Of Cell Death Negative Regulation Of Hydrogen Peroxide-mediated Programmed Cell Death Myoblast Proliferation Positive Regulation Of Fibrinolysis Protein Activation Cascade Positive Regulation Of Plasminogen Activation Regulation Of Metabolic Process Platelet Activation Regulation Of Extrinsic Apoptotic Signaling Pathway Hepatocyte Growth Factor Receptor Signaling Pathway Positive Regulation Of Cell Differentiation Positive Regulation Of Phosphorylation Response To Stress Cellular Response To Hepatocyte Growth Factor Stimulus Regulation Of Branching Involved In Salivary Gland Morphogenesis By Mesenchymal-epithelial Signaling Primitive Hemopoiesis	Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Protein K48-linked Ubiquitination Response To Stress Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Regulation Of DNA-templated Transcription In Response To Stress Negative Regulation Of Blood Coagulation Negative Regulation Of Coagulation Protein Polyubiquitination Proteolysis Negative Regulation Of Wound Healing Blood Coagulation, Intrinsic Pathway Toll-like Receptor 4 Signaling Pathway Extracellular Matrix Disassembly Regulation Of Blood Coagulation Cellular Response To Hypoxia Protein Metabolic Process Cellular Response To Decreased Oxygen Levels Toll-like Receptor Signaling Pathway Cellular Response To Oxygen Levels Response To Hypoxia Fibrinolysis Regulation Of Wound Healing Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Activation Of Innate Immune Response Extracellular Matrix Organization Extracellular Structure Organization Protein Activation Cascade Catabolic Process Positive Regulation Of Innate Immune Response Innate Immune Response Defense Response Collagen Catabolic Process TRIF-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Plasminogen Activation Positive Regulation Of Ubiquitin-protein Transferase Activity Regulation Of Innate Immune Response Positive Regulation Of Ligase Activity Collagen Metabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Immune System Process Multicellular Organismal Macromolecule Metabolic Process Cellular Protein Catabolic Process Regulation Of Body Fluid Levels Protein Ubiquitination Multicellular Organismal Metabolic Process
Tagcloud ?		0x10 18x10 75x10 americans ancestry architecture arr blacks bnp cardioprotective checked cogent consortium copies directions dosages echogen gwa imputed logarithmically lvm motivate natriuretic nppb relations residuals rs198389 rs3733402 whites	amphotropic cem cemss clones deprived engineered episomal geneticin gp160 gp41 hut ltrs neo neomycin nonproducer packaging peculiar plj provirus retroviral retrovirus retroviruses sense ssti superinfecting superinfection syncytia therein uncleaved
Tagcloud (Difference) ?		0x10 18x10 75x10 americans ancestry architecture arr blacks bnp cardioprotective checked cogent consortium copies directions dosages echogen gwa imputed logarithmically lvm motivate natriuretic nppb relations residuals rs198389 rs3733402 whites	amphotropic cem cemss clones deprived engineered episomal geneticin gp160 gp41 hut ltrs neo neomycin nonproducer packaging peculiar plj provirus retroviral retrovirus retroviruses sense ssti superinfecting superinfection syncytia therein uncleaved
Tagcloud (Intersection) ?