KLKB1 and TFPI2

Number of citations of the paper that reports this interaction (PMID 8555184)
20

Data Source:
HPRD (in vitro)

		KLKB1	TFPI2
Gene Name		kallikrein B, plasma (Fletcher factor) 1	tissue factor pathway inhibitor 2
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space Plasma Membrane Extracellular Vesicular Exosome	Proteinaceous Extracellular Matrix Nucleus
	Molecular Function	Serine-type Endopeptidase Activity Protein Binding	Serine-type Endopeptidase Inhibitor Activity Extracellular Matrix Structural Constituent
	Biological Process	Factor XII Activation Proteolysis Blood Coagulation Blood Coagulation, Intrinsic Pathway Extracellular Matrix Disassembly Extracellular Matrix Organization Zymogen Activation Plasminogen Activation Fibrinolysis Positive Regulation Of Fibrinolysis	Blood Coagulation Negative Regulation Of Endopeptidase Activity
Pathways		Intrinsic Pathway Activation of Matrix Metalloproteinases Degradation of the extracellular matrix Formation of Fibrin Clot (Clotting Cascade)
Drugs
Diseases
GWAS		Circulating vasoactive peptide levels ( 23381795) Metabolic traits ( 21886157) Metabolite levels ( 22286219 22916037) Obesity-related traits ( 23251661) Response to statin therapy ( 20339536)
Protein-Protein Interactions		8 interactors: F12 HGF HGFAC IGFBP3 KNG1 MST1 SERPINA5 TFPI2	5 interactors: F11 KLKB1 PLG SKIL SMURF2
Entrez ID		3818	7980
HPRD ID		01971	08962
Ensembl ID		ENSG00000164344	ENSG00000105825
Uniprot IDs		P03952	P48307 Q8NAK6
PDB IDs		2ANW 2ANY	1ZR0
Enriched GO Terms of Interacting Partners?		Regulation Of Protein Processing Blood Coagulation Hemostasis Regulation Of Protein Metabolic Process Regulation Of Body Fluid Levels Wound Healing Negative Regulation Of Endopeptidase Activity Negative Regulation Of Peptidase Activity Response To Wounding Negative Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Proteolysis Negative Regulation Of Protein Processing Negative Regulation Of Protein Metabolic Process Regulation Of Endopeptidase Activity Negative Regulation Of Hydrolase Activity Regulation Of Peptidase Activity Regulation Of Cellular Protein Metabolic Process Blood Coagulation, Intrinsic Pathway Regulation Of Catalytic Activity Regulation Of Proteolysis Negative Regulation Of Catalytic Activity Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Negative Regulation Of Blood Coagulation Negative Regulation Of Coagulation Negative Regulation Of Wound Healing Negative Regulation Of Cellular Metabolic Process Platelet Degranulation Regulation Of Blood Coagulation Factor XII Activation Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Regulation Of Apoptotic Process Regulation Of Wound Healing Positive Regulation Of Cell Death Regulation Of Cell Death Negative Regulation Of Hydrogen Peroxide-mediated Programmed Cell Death Myoblast Proliferation Positive Regulation Of Fibrinolysis Protein Activation Cascade Positive Regulation Of Plasminogen Activation Regulation Of Metabolic Process Platelet Activation Regulation Of Extrinsic Apoptotic Signaling Pathway Hepatocyte Growth Factor Receptor Signaling Pathway Positive Regulation Of Cell Differentiation Positive Regulation Of Phosphorylation Response To Stress Cellular Response To Hepatocyte Growth Factor Stimulus Regulation Of Branching Involved In Salivary Gland Morphogenesis By Mesenchymal-epithelial Signaling Primitive Hemopoiesis	Positive Regulation Of Fibrinolysis Regulation Of Fibrinolysis Negative Regulation Of Blood Coagulation Negative Regulation Of Coagulation Negative Regulation Of Wound Healing Regulation Of Blood Coagulation Plasminogen Activation Regulation Of Wound Healing Blood Coagulation, Intrinsic Pathway Fibrinolysis Blood Coagulation Hemostasis Proteolysis Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Body Fluid Levels Wound Healing Extracellular Matrix Disassembly Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Negative Regulation Of Cellular Response To Growth Factor Stimulus Zymogen Activation Response To Wounding Transforming Growth Factor Beta Receptor Signaling Pathway Factor XII Activation Protein Activation Cascade Transcription Initiation From RNA Polymerase II Promoter Regulation Of Cellular Response To Growth Factor Stimulus Cellular Response To Transforming Growth Factor Beta Stimulus Mononuclear Cell Migration Response To Transforming Growth Factor Beta Negative Regulation Of Cell-cell Adhesion Mediated By Cadherin DNA-templated Transcription, Initiation Protein Processing Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Ubiquitin-dependent SMAD Protein Catabolic Process Positive Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Plasma Kallikrein-kinin Cascade Negative Regulation Of Fibrinolysis Extracellular Matrix Organization Extracellular Structure Organization Protein Heterotrimerization Protein Homotrimerization Trophoblast Giant Cell Differentiation Positive Regulation Of Protein Processing Muscle Structure Development In Utero Embryonic Development Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Response To Stimulus Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process
Tagcloud ?		0x10 18x10 75x10 americans ancestry architecture arr blacks bnp cardioprotective checked cogent consortium copies directions dosages echogen gwa imputed logarithmically lvm motivate natriuretic nppb relations residuals rs198389 rs3733402 whites	anticipated aplp2 appi bikunin canonical cleavage cleave cleaved cocrystal conformation displaying hai2 hepatocyte kunitz mesotrypsin offers p1 polypeptide possessing preferences protease proteolytic selectin stabilization stabilized substrates tfpi1 trypsin uniquely
Tagcloud (Difference) ?		0x10 18x10 75x10 americans ancestry architecture arr blacks bnp cardioprotective checked cogent consortium copies directions dosages echogen gwa imputed logarithmically lvm motivate natriuretic nppb relations residuals rs198389 rs3733402 whites	anticipated aplp2 appi bikunin canonical cleavage cleave cleaved cocrystal conformation displaying hai2 hepatocyte kunitz mesotrypsin offers p1 polypeptide possessing preferences protease proteolytic selectin stabilization stabilized substrates tfpi1 trypsin uniquely
Tagcloud (Intersection) ?