MSH5 and NEU1

Data Source: HiPPIP (Novel)

		MSH5	NEU1
Name		mutS homolog 5	neuraminidase 1
Structure		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus	Extracellular Region Cytoplasm Lysosome Lysosomal Membrane Plasma Membrane Membrane Cell Junction Cytoplasmic Vesicle Specific Granule Lumen Lysosomal Lumen Extracellular Exosome
	Molecular Function	Nucleotide Binding DNA Binding Double-stranded DNA Binding Protein Binding ATP Binding Mismatched DNA Binding ATP-dependent DNA Damage Sensor Activity	Exo-alpha-sialidase Activity Protein Binding Hydrolase Activity Hydrolase Activity, Acting On Glycosyl Bonds Alpha-sialidase Activity
	Biological Process	DNA Repair Mismatch Repair DNA Damage Response Meiosis I Chiasma Assembly Meiotic Cell Cycle	Lipid Metabolic Process Ganglioside Catabolic Process Oligosaccharide Catabolic Process Lipid Catabolic Process
Pathways		Meiotic recombination	Sialic acid metabolism Defective NEU1 causes sialidosis Neutrophil degranulation Glycosphingolipid catabolism
Drugs		None	Oseltamivir Celecoxib Acetylsalicylic acid
Diseases		None	Progressive myoclonic epilepsy (PME), including: Lafora disease (LBD); Unverricht-Lundborg disease (ULD); Neuronal ceroid lipofuscinoses (NCL); Type I sialidosis; Action myoclonus-renal failure syndrome (AMRF); Type III Gaucher disease (GD) Sialidosis; Mucolipidosis I Galactosialidosis
GWAS		A body shape index ( 34021172 ) Asthma ( 31619474 ) Asthma (childhood onset) ( 31619474 ) Asthma and major depressive disorder ( 31619474 ) Autism spectrum disorder or schizophrenia ( 28540026 ) Blond vs. brown/black hair color ( 30531825 ) Clozapine-induced agranulocytosis/granulocytopenia in treatment-resistant schizophrenia ( 26876947 ) Cutaneous lupus erythematosus ( 25827949 ) Hip circumference adjusted for BMI ( 34021172 ) Inflammatory bowel disease ( 28067908 ) Lung cancer ( 18978787 ) Mastocytosis ( 32752121 ) Medication use (anilides) ( 31015401 ) Menopause (age at onset) ( 26414677 ) Pulse pressure ( 27618448 ) Systemic lupus erythematosus ( 26316170 ) Systemic mastocytosis ( 32752121 ) Systolic blood pressure ( 27618448 ) Takayasu arteritis ( 25604533 ) Ulcerative colitis ( 28067908 24837172 )	A body shape index ( 34021172 ) Asthma ( 31619474 ) Asthma (childhood onset) ( 31619474 ) Asthma and major depressive disorder ( 31619474 ) Autism spectrum disorder or schizophrenia ( 28540026 ) Basal cell carcinoma ( 27539887 ) Estimated glomerular filtration rate ( 31152163 ) Inflammatory bowel disease ( 28067908 ) Neutrophil percentage of white cells ( 32888494 ) Platelet distribution width ( 32888494 ) Small cell lung carcinoma ( 28604730 ) Squamous cell lung carcinoma ( 28604730 ) Ulcerative colitis ( 28067908 ) Waist-hip index ( 34021172 )
Novel Interactors		2 novel interactors: NEU1 NOTCH4	8 novel interactors: CDC42SE2 IGF1 MAF MSH5 NFYA NOTCH4 PBX2 SLC17A2
Interacting Genes		4 interacting genes: MLH1 MLH3 MSH4 TRIM54	30 interacting genes: AQP6 CCR9 CD79A CERS3 CERS4 CREB3 CREB3L1 CTSA EBP EEF1A1 ERGIC3 ERRFI1 GLB1 GOLM1 GPR152 GPX8 HSD17B11 JUNB KCNA2 KCNA4 LIG4 LMNA MGST3 MUC1 SLC10A1 SLC10A6 SLC18A1 SLC39A9 TMEM14B UBC
Entrez ID		4439	4758
HPRD ID		04544	09751
Ensembl ID		ENSG00000204410	ENSG00000204386
Uniprot IDs		A0A024RCM1 O43196	Q5JQI0 Q99519
PDB IDs		Not available	Not available
GO Terms Enriched among Interactors		Mismatched DNA Binding ATP-dependent DNA Damage Sensor Activity Mismatch Repair Reciprocal Meiotic Recombination Chiasma Synaptonemal Complex Condensed Chromosome Homologous Recombination Condensed Nuclear Chromosome Chromosome Organization Involved In Meiotic Cell Cycle Mismatch Repair Complex Homologous Chromosome Pairing At Meiosis DNA Recombination Male Meiotic Nuclear Division Male Germ Cell Nucleus Chromosome Organization Female Gamete Generation Meiosis I Cell Cycle Process Meiotic Nuclear Division Late Recombination Nodule Meiotic Metaphase I Homologous Chromosome Alignment Recombination Nodule Nuclear Division Reproductive Process DNA Repair Meiotic Cell Cycle Meiotic Spindle Midzone Assembly Meiotic Metaphase Chromosome Alignment Alpha-sialidase Activity Male Meiosis Chromosome Segregation MutLalpha Complex DNA Metabolic Process Guanine/thymine Mispair Binding Negative Regulation Of Mitotic Recombination Exo-alpha-sialidase Activity Satellite DNA Binding DNA Damage Response Homologous Chromosome Segregation Female Meiosis Chromosome Segregation Luteolysis Positive Regulation Of Isotype Switching To IgA Isotypes Centromeric DNA Binding MutSalpha Complex Binding Regulation Of Mitotic Recombination Positive Regulation Of Transcription Of Notch Receptor Target Female Meiosis I Meiotic Telomere Clustering Chromosome Localization To Nuclear Envelope Involved In Homologous Chromosome Segregation Ganglioside Catabolic Process Telomere Localization	Membrane Endoplasmic Reticulum Membrane Bile Acid:sodium Symporter Activity Integrated Stress Response Signaling Sphingosine N-acyltransferase Activity Regulation Of Chaperone-mediated Autophagy Lung Vasculature Development Negative Regulation Of Apoptotic Signaling Pathway Vasculature Development RNA Polymerase II Transcription Regulator Complex Voltage-gated Monoatomic Ion Channel Activity Involved In Regulation Of Presynaptic Membrane Potential Negative Regulation Of Cardiac Muscle Hypertrophy In Response To Stress Regulation Of Type B Pancreatic Cell Proliferation Endoplasmic Reticulum Regulation Of Cardiac Muscle Hypertrophy