NEU1 and SLC17A2

		NEU1	SLC17A2
Description		neuraminidase 1	solute carrier family 17 member 2
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Extracellular Region Cytoplasm Lysosome Lysosomal Membrane Plasma Membrane Membrane Cell Junction Cytoplasmic Vesicle Specific Granule Lumen Lysosomal Lumen Extracellular Exosome	Plasma Membrane Membrane Apical Plasma Membrane
	Molecular Function	Exo-alpha-sialidase Activity Protein Binding Hydrolase Activity Hydrolase Activity, Acting On Glycosyl Bonds Alpha-sialidase Activity	Sodium:phosphate Symporter Activity Urate Transmembrane Transporter Activity Symporter Activity Transmembrane Transporter Activity
	Biological Process	Lipid Metabolic Process Ganglioside Catabolic Process Oligosaccharide Catabolic Process Lipid Catabolic Process	Phosphate-containing Compound Metabolic Process Monoatomic Ion Transport Sodium Ion Transport Inorganic Anion Transport Urate Transport Sodium Ion Transmembrane Transport Transmembrane Transport
Pathways		Sialic acid metabolism Defective NEU1 causes sialidosis Neutrophil degranulation Glycosphingolipid catabolism
Drugs		Oseltamivir Celecoxib Acetylsalicylic acid
Diseases		Progressive myoclonic epilepsy (PME), including: Lafora disease (LBD); Unverricht-Lundborg disease (ULD); Neuronal ceroid lipofuscinoses (NCL); Type I sialidosis; Action myoclonus-renal failure syndrome (AMRF); Type III Gaucher disease (GD) Sialidosis; Mucolipidosis I Galactosialidosis
GWAS		A body shape index ( 34021172) Asthma ( 31619474) Asthma (childhood onset) ( 31619474) Asthma and major depressive disorder ( 31619474) Autism spectrum disorder or schizophrenia ( 28540026) Basal cell carcinoma ( 27539887) Estimated glomerular filtration rate ( 31152163) Inflammatory bowel disease ( 28067908) Neutrophil percentage of white cells ( 32888494) Platelet distribution width ( 32888494) Small cell lung carcinoma ( 28604730) Squamous cell lung carcinoma ( 28604730) Ulcerative colitis ( 28067908) Waist-hip index ( 34021172)	Autism spectrum disorder or schizophrenia ( 28540026) Blood pressure ( 24954895) Brain morphology (MOSTest) ( 32665545) Fish- and plant-related diet ( 32066663) Height ( 25429064) Hemoglobin levels ( 32327693) Iron status biomarkers (total iron binding capacity) ( 28334935) Iron status biomarkers (transferrin saturation) ( 28334935) LDL cholesterol ( 30275531) Mean corpuscular hemoglobin ( 27863252) Mean corpuscular volume ( 27863252) Oily fish consumption ( 32066663) Red cell distribution width ( 27863252 28957414 32888494) Refractive error ( 32231278) Serum uric acid levels ( 32514006) Subcortical volume (MOSTest) ( 32665545) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)
Interacting Genes		30 interacting genes: AQP6 CCR9 CD79A CERS3 CERS4 CREB3 CREB3L1 CTSA EBP EEF1A1 ERGIC3 ERRFI1 GLB1 GOLM1 GPR152 GPX8 HSD17B11 JUNB KCNA2 KCNA4 LIG4 LMNA MGST3 MUC1 SLC10A1 SLC10A6 SLC18A1 SLC39A9 TMEM14B UBC
Entrez ID		4758	10246
HPRD ID		09751	10232
Ensembl ID		ENSG00000204386	ENSG00000112337
Uniprot IDs		Q5JQI0 Q99519	O00624
PDB IDs
Enriched GO Terms of Interacting Partners?		Membrane Endoplasmic Reticulum Membrane Bile Acid:sodium Symporter Activity Integrated Stress Response Signaling Sphingosine N-acyltransferase Activity Regulation Of Chaperone-mediated Autophagy Lung Vasculature Development Negative Regulation Of Apoptotic Signaling Pathway Vasculature Development RNA Polymerase II Transcription Regulator Complex Voltage-gated Monoatomic Ion Channel Activity Involved In Regulation Of Presynaptic Membrane Potential Negative Regulation Of Cardiac Muscle Hypertrophy In Response To Stress Regulation Of Type B Pancreatic Cell Proliferation Endoplasmic Reticulum Regulation Of Cardiac Muscle Hypertrophy	Alpha-sialidase Activity Exo-alpha-sialidase Activity Ganglioside Catabolic Process Glycosphingolipid Catabolic Process Glycolipid Catabolic Process Ceramide Catabolic Process Oligosaccharide Catabolic Process Ganglioside Metabolic Process Sphingolipid Catabolic Process Membrane Lipid Catabolic Process Oligosaccharide Metabolic Process Specific Granule Lumen Glycosphingolipid Metabolic Process Hydrolase Activity, Acting On Glycosyl Bonds Glycolipid Metabolic Process Ceramide Metabolic Process Lysosomal Lumen Carbohydrate Catabolic Process Sphingolipid Metabolic Process Membrane Lipid Metabolic Process Cell Junction Carbohydrate Derivative Catabolic Process Lipid Catabolic Process Carbohydrate Metabolic Process Lysosomal Membrane Lysosome
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