ASPA and ZYG11B

Data Source: HiPPIP (Novel)

		ASPA	ZYG11B
Name		aspartoacylase	zyg-11 family member B, cell cycle regulator
Structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol	Cytoplasm Cul2-RING Ubiquitin Ligase Complex
	Molecular Function	Protein Binding Hydrolase Activity Hydrolase Activity, Acting On Ester Bonds Hydrolase Activity, Acting On Carbon-nitrogen (but Not Peptide) Bonds, In Linear Amides Aspartoacylase Activity Identical Protein Binding Metal Ion Binding	Protein Binding
	Biological Process	Acetate Metabolic Process Aspartate Metabolic Process	Protein Quality Control For Misfolded Or Incompletely Synthesized Proteins Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Pathways		Aspartate and asparagine metabolism	None
Drugs		Aspartic acid Zinc Zinc acetate Zinc chloride Zinc sulfate, unspecified form	None
Diseases		Canavan disease (CD)	None
GWAS		Myopia (pathological) ( 23049088 )	Monocyte percentage of white cells ( 32888494 )
Novel Interactors		1 novel interactors: ZYG11B	10 novel interactors: ARPC2 ASPA BTBD2 BTF3L4 CFL2 NDC1 OSBPL9 SH2D2A TLR6 UCK2
Interacting Genes		3 interacting genes: ACY3 DUSP29 HUNK	4 interacting genes: CUL2 ELOB ELOC GBF1
Entrez ID		443	79699
HPRD ID		02033	13356
Ensembl ID		ENSG00000108381	ENSG00000162378
Uniprot IDs		P45381 Q6FH48	A8DPD7 B4DK95 Q9C0D3
PDB IDs		2I3C 2O4H 2O53 2Q51 4MRI 4MXU 4NFR 4TNU	7EP0 7EP1 7EP2 7XV7 7XYV 7XYW 7XYX 7YC2
GO Terms Enriched among Interactors		None	Cul2-RING Ubiquitin Ligase Complex Target-directed MiRNA Degradation Elongin Complex Negative Regulation Of Post-transcriptional Gene Silencing By Regulatory NcRNA Negative Regulation Of MiRNA-mediated Gene Silencing MiRNA Catabolic Process Cul5-RING Ubiquitin Ligase Complex MiRNA Metabolic Process Regulation Of Post-transcriptional Gene Silencing Regulation Of MiRNA-mediated Gene Silencing Aspartoacylase Activity Protein-macromolecule Adaptor Activity Transcription Corepressor Binding Transcription Initiation At RNA Polymerase II Promoter Protein Localization To Endoplasmic Reticulum Tubular Network Diacyl Lipopeptide Binding Nuclear Pore Transmembrane Ring Actin Polymerization Or Depolymerization Cell Leading Edge Actin Cytoskeleton Golgi Apparatus Subcompartment Endoplasmic Reticulum-Golgi Intermediate Compartment Organization Toll-like Receptor 2-Toll-like Receptor 6 Protein Complex Detection Of Diacyl Bacterial Lipopeptide DNA-templated Transcription Initiation Acetate Metabolic Process Cytosol VCB Complex CTP Salvage Muscle Cell Projection Membrane Actin Filament Fragmentation Cytidine Kinase Activity Uridine Kinase Activity CMP Biosynthetic Process Endomembrane System Organization Toll-like Receptor 2 Binding Detection Of Bacterial Lipoprotein Toll-like Receptor TLR6:TLR2 Signaling Pathway