ASPA and DUSP29

Number of citations: 50 (PubMedID 32296183)
Data Source: BioGRID (two hybrid)

		ASPA	DUSP29
Name		aspartoacylase	dual specificity phosphatase 29
Structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol	Nucleus Cytoplasm Protein-containing Complex
	Molecular Function	Protein Binding Hydrolase Activity Hydrolase Activity, Acting On Ester Bonds Hydrolase Activity, Acting On Carbon-nitrogen (but Not Peptide) Bonds, In Linear Amides Aspartoacylase Activity Identical Protein Binding Metal Ion Binding	Phosphoprotein Phosphatase Activity Protein Serine/threonine Phosphatase Activity Protein Tyrosine Phosphatase Activity Protein Binding Protein Tyrosine/serine/threonine Phosphatase Activity Hydrolase Activity Phosphatase Activity MAP Kinase Phosphatase Activity Protein Homodimerization Activity
	Biological Process	Acetate Metabolic Process Aspartate Metabolic Process	Protein Dephosphorylation Glucose Homeostasis Muscle Cell Differentiation Negative Regulation Of MAPK Cascade Negative Regulation Of ERK1 And ERK2 Cascade
Pathways		Aspartate and asparagine metabolism	None
Drugs		Aspartic acid Zinc Zinc acetate Zinc chloride Zinc sulfate, unspecified form	None
Diseases		Canavan disease (CD)	None
GWAS		Myopia (pathological) ( 23049088 )	No GWAS studies recorded
Novel Interactors		1 novel interactors: ZYG11B	None recorded
Interacting Genes		3 interacting genes: ACY3 DUSP29 HUNK	25 interacting genes: AATK ARPC3 ASPA C17orf75 CNTROB DDIT4L EPHA2 ERBB3 GOLGA6A IGF1R LMTK2 LNX1 NIF3L1 NOC4L PICK1 POLR2G PSMB5 PTK7 RNF40 ROR1 ROR2 SRSF11 STX11 TCF4 TEPSIN
Entrez ID		443	338599
HPRD ID		02033	16846
Ensembl ID		ENSG00000108381	ENSG00000188716
Uniprot IDs		P45381 Q6FH48	Q68J44
PDB IDs		2I3C 2O4H 2O53 2Q51 4MRI 4MXU 4NFR 4TNU	2Y96
GO Terms Enriched among Interactors		None	Transmembrane Receptor Protein Tyrosine Kinase Activity Protein Kinase Activity Protein Tyrosine Kinase Activity Receptor Complex Kinase Activity Glial Cell Development Dendritic Spine Maintenance Coreceptor Activity Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Transferase Activity ATP Binding