KRTAP5-6 and RGS17

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		KRTAP5-6	RGS17
Description		keratin associated protein 5-6	regulator of G protein signaling 17
Image		No pdb structure
GO Annotations	Cellular Component	Cytosol Intermediate Filament	Nucleus Cytoplasm Plasma Membrane Membrane Neuron Projection Synapse
	Molecular Function	Protein Binding	GTPase Activity GTPase Activator Activity Protein Binding
	Biological Process		Response To Amphetamine G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Signal Transduction
Pathways		Keratinization	G alpha (q) signalling events G alpha (i) signalling events G alpha (z) signalling events G alpha (z) signalling events
Drugs
Diseases
GWAS		Logical memory (delayed recall) in mild cognitive impairment ( 29274321)	Adult body size ( 32376654) Alcohol dependence ( 26365420) Apolipoprotein A1 levels ( 32203549) Bacterial meningitis ( 31092817) Body mass index ( 28892062) Cuneus cortex volume ( 31530798) Diastolic blood pressure ( 30224653) Fasting glucose ( 34059833) General risk tolerance (MTAG) ( 30643258) HDL cholesterol levels ( 32203549) High density lipoprotein cholesterol levels ( 29083408) Lipoprotein (a) levels ( 26377243) Morning person ( 30696823) Pneumococcal meningitis ( 31092817) Prostate cancer ( 23535732) Triglyceride levels ( 32203549) Type 2 diabetes or prostate cancer (pleiotropy) ( 33290408) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)
Interacting Genes		93 interacting genes: ADAM12 ADAMTSL4 CATSPER1 CCN3 COL8A1 CRCT1 CREB5 CYSRT1 DDIT4L GLRX3 GUCD1 HOXA1 INCA1 KRT31 KRTAP1-1 KRTAP1-3 KRTAP1-5 KRTAP10-1 KRTAP10-10 KRTAP10-11 KRTAP10-3 KRTAP10-5 KRTAP10-6 KRTAP10-7 KRTAP10-8 KRTAP10-9 KRTAP11-1 KRTAP12-1 KRTAP12-3 KRTAP13-3 KRTAP17-1 KRTAP26-1 KRTAP3-3 KRTAP4-1 KRTAP4-11 KRTAP4-12 KRTAP4-2 KRTAP4-4 KRTAP4-5 KRTAP5-1 KRTAP5-11 KRTAP5-2 KRTAP5-3 KRTAP5-4 KRTAP5-7 KRTAP5-9 KRTAP9-2 KRTAP9-3 KRTAP9-4 KRTAP9-8 LBX1 LCE1A LCE1B LCE1C LCE1D LCE1E LCE1F LCE2A LCE2B LCE2C LCE2D LCE3A LCE3B LCE3C LCE3D LCE3E LCE4A LCE5A LELP1 LINGO1 MAPKBP1 MEOX2 MYPOP NBPF19 NLK NOTCH2NLA NOTO NR1D2 NR4A3 NUFIP2 OTX1 OXER1 PLSCR1 POU4F2 RGS17 RGS19 RGS20 SMCP SPRY2 TRIM42 VASN VGLL3 YY1	45 interacting genes: ADRB2 AQP1 BOLA2 BOLA2B CHRD CRCT1 CREB5 DHX37 GNAI1 GNAI3 HINT1 HOXA1 HSD3B7 KRTAP4-11 KRTAP5-11 KRTAP5-3 KRTAP5-4 KRTAP5-6 LCE1A LCE1B LCE1D LCE1E LCE1F LCE2A LCE2B LCE2C LCE3A LCE3B LCE3C LCE3D LCE3E LCE4A LCE5A NUFIP2 OSTM1 OTX1 PTGER3 RABEP1 RBBP8 RPL10A SLC39A7 SMCP STUB1 TBC1D16 VASN
Entrez ID		440023	26575
HPRD ID		17250	06223
Ensembl ID		ENSG00000205864	ENSG00000091844
Uniprot IDs		Q6L8G9	Q9UGC6
PDB IDs			1ZV4 6AM3
Enriched GO Terms of Interacting Partners?		Intermediate Filament Keratin Filament Keratinization Epidermis Development Tissue Development Hair Cycle Protein Binding Identical Protein Binding Cytosol	Keratinization Epidermis Development Tissue Development Protein Binding Intermediate Filament Defense Response To Gram-negative Bacterium [2Fe-2S] Cluster Assembly Identical Protein Binding Negative Regulation Of Smooth Muscle Contraction Iron-sulfur Cluster Assembly Complex
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