KRTAP5-6 and NR4A3

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		KRTAP5-6	NR4A3
Description		keratin associated protein 5-6	nuclear receptor subfamily 4 group A member 3
Image		No pdb structure
GO Annotations	Cellular Component	Cytosol Intermediate Filament	Chromatin Nucleus Nucleoplasm Transcription Regulator Complex
	Molecular Function	Protein Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity Transcription Coactivator Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Nuclear Steroid Receptor Activity Nuclear Receptor Activity Protein Binding Zinc Ion Binding Protein Kinase Binding Histone Acetyltransferase Binding Nuclear Glucocorticoid Receptor Binding CAMP Response Element Binding Protein Homodimerization Activity Sequence-specific DNA Binding Metal Ion Binding
	Biological Process		Negative Regulation Of Transcription By RNA Polymerase II Mesoderm Formation Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Gastrulation Axon Guidance Positive Regulation Of Cardiac Muscle Hypertrophy Positive Regulation Of D-glucose Transmembrane Transport Hippocampus Development Nuclear Receptor-mediated Steroid Hormone Signaling Pathway Intracellular Receptor Signaling Pathway Adult Behavior Positive Regulation Of Mast Cell Cytokine Production Smooth Muscle Cell Apoptotic Process Negative Regulation Of Smooth Muscle Cell Apoptotic Process Intracellular Signal Transduction Common Myeloid Progenitor Cell Proliferation Positive Regulation Of Mast Cell Activation By Fc-epsilon Receptor Signaling Pathway Inner Ear Morphogenesis Response To Hydrogen Peroxide Mast Cell Degranulation Negative Regulation Of Neuron Apoptotic Process Cellular Response To Leptin Stimulus Cellular Respiration Fat Cell Differentiation Positive Regulation Of Cell Cycle Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Platelet-derived Growth Factor Receptor Signaling Pathway Regulation Of Smooth Muscle Cell Proliferation Positive Regulation Of Smooth Muscle Cell Proliferation Semicircular Canal Morphogenesis Positive Regulation Of Epithelial Cell Proliferation Neuromuscular Process Controlling Balance Neuron Apoptotic Process Vestibular Reflex Regulation Of Type B Pancreatic Cell Proliferation Cellular Response To Corticotropin-releasing Hormone Stimulus Cellular Response To Catecholamine Stimulus Energy Homeostasis Dendritic Cell Apoptotic Process Positive Regulation Of Monocyte Aggregation Positive Regulation Of Vascular Associated Smooth Muscle Cell Proliferation Positive Regulation Of Vascular Associated Smooth Muscle Cell Migration Positive Regulation Of Feeding Behavior Positive Regulation Of Dendritic Cell Apoptotic Process
Pathways		Keratinization	RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function
Drugs			Dasatinib
Diseases			Extraskeletal myxoid chondrosarcoma
GWAS		Logical memory (delayed recall) in mild cognitive impairment ( 29274321)	Dental caries ( 23064961) Depression in smokers ( 30219690) Eosinophil percentage of white cells ( 32888494) Lung cancer ( 28604730) Systemic lupus erythematosus ( 33536424) Type 1 diabetes ( 34127860)
Interacting Genes		93 interacting genes: ADAM12 ADAMTSL4 CATSPER1 CCN3 COL8A1 CRCT1 CREB5 CYSRT1 DDIT4L GLRX3 GUCD1 HOXA1 INCA1 KRT31 KRTAP1-1 KRTAP1-3 KRTAP1-5 KRTAP10-1 KRTAP10-10 KRTAP10-11 KRTAP10-3 KRTAP10-5 KRTAP10-6 KRTAP10-7 KRTAP10-8 KRTAP10-9 KRTAP11-1 KRTAP12-1 KRTAP12-3 KRTAP13-3 KRTAP17-1 KRTAP26-1 KRTAP3-3 KRTAP4-1 KRTAP4-11 KRTAP4-12 KRTAP4-2 KRTAP4-4 KRTAP4-5 KRTAP5-1 KRTAP5-11 KRTAP5-2 KRTAP5-3 KRTAP5-4 KRTAP5-7 KRTAP5-9 KRTAP9-2 KRTAP9-3 KRTAP9-4 KRTAP9-8 LBX1 LCE1A LCE1B LCE1C LCE1D LCE1E LCE1F LCE2A LCE2B LCE2C LCE2D LCE3A LCE3B LCE3C LCE3D LCE3E LCE4A LCE5A LELP1 LINGO1 MAPKBP1 MEOX2 MYPOP NBPF19 NLK NOTCH2NLA NOTO NR1D2 NR4A3 NUFIP2 OTX1 OXER1 PLSCR1 POU4F2 RGS17 RGS19 RGS20 SMCP SPRY2 TRIM42 VASN VGLL3 YY1	43 interacting genes: ADAMTSL4 ALPP CDKN2D CHRD COPS5 CYP21A2 CYSRT1 EFEMP1 HSD3B7 KPRP KRTAP10-1 KRTAP10-5 KRTAP10-8 KRTAP12-3 KRTAP12-4 KRTAP4-11 KRTAP4-2 KRTAP4-4 KRTAP5-11 KRTAP5-3 KRTAP5-6 KRTAP5-9 KRTAP6-3 KRTAP9-2 KRTAP9-3 KRTAP9-8 LCE2B LCE2D MACO1 NECTIN2 PCSK5 PIN1 RECK RPS6KA1 SIX3 SMOC1 TRIM28 TSPAN4 UBE3A VASN VHL VWC2L ZNF330
Entrez ID		440023	8013
HPRD ID		17250	02766
Ensembl ID		ENSG00000205864	ENSG00000119508
Uniprot IDs		Q6L8G9	Q92570
PDB IDs			8XTT
Enriched GO Terms of Interacting Partners?		Intermediate Filament Keratin Filament Keratinization Epidermis Development Tissue Development Hair Cycle Protein Binding Identical Protein Binding Cytosol	Intermediate Filament Keratin Filament Hair Cycle Epidermis Development Embryo Implantation
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