ASNS and STRN4

Number of citations of the paper that reports this interaction (PMID 16169070)
531

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		ASNS	STRN4
Gene Name		asparagine synthetase (glutamine-hydrolyzing)	striatin, calmodulin binding protein 4
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Cytosol	Protein Phosphatase Type 2A Complex Cytoplasm Membrane Dendritic Spine
	Molecular Function	Asparagine Synthase (glutamine-hydrolyzing) Activity ATP Binding Protein Homodimerization Activity Cofactor Binding	Protein Binding Calmodulin Binding Protein Complex Binding Protein Phosphatase 2A Binding Armadillo Repeat Domain Binding
	Biological Process	Liver Development Asparagine Biosynthetic Process Glutamine Metabolic Process Activation Of Signaling Protein Activity Involved In Unfolded Protein Response Cellular Amino Acid Biosynthetic Process Response To Light Stimulus Response To Mechanical Stimulus Response To Toxic Substance Endoplasmic Reticulum Unfolded Protein Response Response To Methotrexate Response To Follicle-stimulating Hormone Cellular Response To Hormone Stimulus Cellular Nitrogen Compound Metabolic Process Cellular Response To Glucose Starvation Negative Regulation Of Apoptotic Process Response To Amino Acid Cellular Protein Metabolic Process Small Molecule Metabolic Process Positive Regulation Of Mitotic Cell Cycle L-asparagine Biosynthetic Process	Biological_process
Pathways		Amino acid synthesis and interconversion (transamination) ATF4 activates genes PERK regulates gene expression Unfolded Protein Response (UPR) Metabolism of amino acids and derivatives
Drugs		L-Aspartic Acid L-Glutamic Acid Adenosine triphosphate L-Asparagine
Diseases
GWAS			Chronic lymphocytic leukemia ( 18758461)
Protein-Protein Interactions		4 interactors: ATXN1 STRN4 TRIM69 WDR27	22 interactors: AK5 ASNS CALM1 CAV1 CLDN12 DDX39B DFFA ECSIT GDF9 JUN KLHDC2 LPPR3 MIF MSANTD2 MTG1 NBEA PBDC1 PI4KA PPBP SLC25A6 WIPI2 WNT7A
Entrez ID		440	29888
HPRD ID		00153	18125
Ensembl ID		ENSG00000070669	ENSG00000090372
Uniprot IDs		P08243	F5GYK2 F8VYA6 Q59GV6 Q9NRL3
PDB IDs
Enriched GO Terms of Interacting Partners?			Regulation Of Protein Autophosphorylation Cellular Response To Starvation Cellular Response To Nutrient Levels Response To Starvation Cellular Response To Extracellular Stimulus Regulation Of Oxidoreductase Activity Negative Regulation Of Protein Autophosphorylation Positive Regulation Of Phosphorylation Regulation Of Phosphorylation Response To External Stimulus Response To Organic Cyclic Compound Cellular Localization Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Negative Regulation Of Cell Death Regulation Of Apoptotic Process Response To Calcium Ion Regulation Of Phosphorus Metabolic Process Regulation Of Cell Death Regulation Of Protein Phosphorylation Response To Wounding Positive Regulation Of Protein Phosphorylation Nitric Oxide Metabolic Process Mitochondrion Organization Reactive Nitrogen Species Metabolic Process Response To Nutrient Levels Regulation Of Nitric-oxide Synthase Activity Cellular Response To Transforming Growth Factor Beta Stimulus Regulation Of Immune System Process Response To Extracellular Stimulus Response To Lipid Response To Transforming Growth Factor Beta Response To Organic Substance Positive Regulation Of Ion Transport Cell Communication Positive Regulation Of Cellular Metabolic Process Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Modification Process Negative Regulation Of Ion Transmembrane Transport Regulation Of Cell Cycle Establishment Of Localization In Cell Regulation Of Membrane Repolarization During Action Potential Positive Regulation Of Prostaglandin Secretion Involved In Immune Response DADP Biosynthetic Process Negative Regulation Of Peptidyl-tyrosine Autophosphorylation Wnt Signaling Pathway Involved In Wound Healing, Spreading Of Epidermal Cells Negative Regulation Of Apoptotic DNA Fragmentation Cellular Response To Potassium Ion Starvation L-asparagine Biosynthetic Process
Tagcloud ?		accordingly alters asparagine atf4 captures connection delivers extracellularly gas hemolysin inflict internalized irreversible multiplication nutrients obviating pathogens poorly senses slo sls streptococcus streptolysin synthetase toxins trigger unfolded upr
Tagcloud (Difference) ?		accordingly alters asparagine atf4 captures connection delivers extracellularly gas hemolysin inflict internalized irreversible multiplication nutrients obviating pathogens poorly senses slo sls streptococcus streptolysin synthetase toxins trigger unfolded upr
Tagcloud (Intersection) ?