STRN4 and MIF

Number of citations of the paper that reports this interaction (PubMedID 16169070)
0

Data Source:
HPRD (two hybrid)

		STRN4	MIF
Description		striatin 4	macrophage migration inhibitory factor
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Dendrite Protein-containing Complex Neuronal Cell Body Dendritic Spine FAR/SIN/STRIPAK Complex Postsynapse Glutamatergic Synapse GABA-ergic Synapse	Extracellular Region Extracellular Space Nucleoplasm Cytoplasm Cytosol Plasma Membrane Cell Surface Vesicle Secretory Granule Lumen Extracellular Exosome Ficolin-1-rich Granule Lumen
	Molecular Function	Protein Binding Calmodulin Binding Protein Domain Specific Binding Protein-macromolecule Adaptor Activity Protein-containing Complex Binding Protein Phosphatase 2A Binding Armadillo Repeat Domain Binding	Protease Binding Dopachrome Isomerase Activity Cytokine Activity Cytokine Receptor Binding Protein Binding Isomerase Activity Chemoattractant Activity Identical Protein Binding Phenylpyruvate Tautomerase Activity
	Biological Process	Negative Regulation Of Hippo Signaling Regulation Of Modification Of Postsynaptic Structure	Prostaglandin Biosynthetic Process Positive Regulation Of Cytokine Production Immune System Process Negative Regulation Of Mature B Cell Apoptotic Process Inflammatory Response Cell Surface Receptor Signaling Pathway Positive Regulation Of Cell Population Proliferation Negative Regulation Of Gene Expression Negative Regulation Of Macrophage Chemotaxis Carboxylic Acid Metabolic Process DNA Damage Response, Signal Transduction By P53 Class Mediator Negative Regulation Of Cell Migration Positive Regulation Of B Cell Proliferation Positive Regulation Of Lipopolysaccharide-mediated Signaling Pathway Positive Regulation Of Tumor Necrosis Factor Production Negative Regulation Of Myeloid Cell Apoptotic Process Regulation Of Cell Population Proliferation Positive Regulation Of Phosphorylation Regulation Of Macrophage Activation Negative Regulation Of Apoptotic Process Negative Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Innate Immune Response Positive Regulation Of Fibroblast Proliferation Positive Chemotaxis Negative Regulation Of Protein Metabolic Process Positive Regulation Of Prostaglandin Secretion Involved In Immune Response Positive Regulation Of Myeloid Leukocyte Cytokine Production Involved In Immune Response Protein Homotrimerization Positive Regulation Of ERK1 And ERK2 Cascade Regulation Of Cellular Response To Stress Positive Regulation Of Arachidonate Secretion Cellular Senescence Positive Regulation Of CAMP/PKA Signal Transduction Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Positive Regulation Of Chemokine (C-X-C Motif) Ligand 2 Production Negative Regulation Of Cellular Senescence
Pathways			Cell surface interactions at the vascular wall Neutrophil degranulation Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation
Drugs			3,4-Dihydroxycinnamic Acid 7-Hydroxy-2-Oxo-Chromene-3-Carboxylic Acid Ethyl Ester 4-Hydroxyphenylpyruvic acid 3-(4-HYDROXYPHENYL)-4,5-DIHYDRO-5-ISOXAZOLE-ACETIC ACID METHYL ESTER 4-HYDROXYBENZALDEHYDE O-(CYCLOHEXYLCARBONYL)OXIME 3-FLUORO-4-HYDROXYBENZALDEHYDE O-(CYCLOHEXYLCARBONYL)OXIME 4-HYDROXYBENZALDEHYDE O-(3,3-DIMETHYLBUTANOYL)OXIME 6-HYDROXY-1,3-BENZOTHIAZOLE-2-SULFONAMIDE
Diseases
GWAS		Aspartate aminotransferase levels ( 33547301) Chronic lymphocytic leukemia ( 18758461 28165464) Primary sclerosing cholangitis ( 23603763)	Alanine aminotransferase levels ( 33547301) Blood protein levels ( 30072576) Liver enzyme levels (gamma-glutamyl transferase) ( 22001757) Macrophage Migration Inhibitory Factor levels ( 27989323) Serum alkaline phosphatase levels ( 33547301)
Interacting Genes		28 interacting genes: AK5 ASNS CALM1 CAV1 CLDN12 CRK DDX39B DFFA ECSIT GDF9 JUN KLHDC2 MAP4K1 MAP4K2 MAP4K3 MAP4K4 MIF MSANTD2 MTG1 NBEA PBDC1 PI4KA PLPPR3 PPBP SLC25A6 TNIK WIPI2 WNT7A	15 interacting genes: BEX3 BNIPL CD74 CEBPA COPS5 COPS6 EGFR EXOSC7 GORASP2 NME1 NTAQ1 STRN4 TP53 UPF2 ZNF408
Entrez ID		29888	4282
HPRD ID		18125	01091
Ensembl ID		ENSG00000090372	ENSG00000240972
Uniprot IDs		F5GYK2 Q59GV6 Q9NRL3	I4AY87 P14174
PDB IDs			1CA7 1CGQ 1GCZ 1GD0 1GIF 1LJT 1MIF 1P1G 2OOH 2OOW 2OOZ 3B9S 3CE4 3DJH 3DJI 3HOF 3IJG 3IJJ 3JSF 3JSG 3JTU 3L5P 3L5R 3L5S 3L5T 3L5U 3L5V 3SMB 3SMC 3U18 3WNR 3WNS 3WNT 4ETG 4EUI 4EVG 4F2K 4GRN 4GRO 4GRP 4GRQ 4GRR 4GRU 4GUM 4K9G 4OSF 4OYQ 4P01 4P0H 4PKK 4PKZ 4PLU 4TRF 4TRU 4WR8 4WRB 4XX7 4XX8 4Z15 4Z1T 4Z1U 5B4O 5BS9 5BSC 5BSI 5BSJ 5EIZ 5HVS 5HVT 5HVV 5J7P 5J7Q 5UMJ 5UMK 5UZY 5V70 5V73 5XEJ 6B1C 6B1K 6B2C 6BG6 6BG7 6CB5 6CBF 6CBG 6CBH 6FVE 6FVH 6OY8 6OYB 6OYE 6OYG 6PEG 7E45 7E47 7E49 7E4A 7E4B 7E4C 7KQX 7XTX 7XVX 8CA0 8IMR 8SON 8SPN 8TT9 9BNQ 9BNR
Enriched GO Terms of Interacting Partners?		MAP Kinase Kinase Kinase Kinase Activity MAPK Cascade Regulation Of MAPK Cascade JNK Cascade Regulation Of JNK Cascade Intracellular Signaling Cassette Positive Regulation Of MAPK Cascade Positive Regulation Of JNK Cascade Negative Regulation Of Apoptotic Process Positive Regulation Of Intracellular Signal Transduction Kinase Activity Intracellular Signal Transduction Negative Regulation Of Programmed Cell Death Positive Regulation Of Signal Transduction Regulation Of Cell Communication By Electrical Coupling Involved In Cardiac Conduction Cellular Response To Transforming Growth Factor Beta Stimulus Nucleotide Binding ATP Binding Response To Transforming Growth Factor Beta Protein Serine Kinase Activity Protein Phosphorylation Signal Transduction Regulation Of Cell Communication By Electrical Coupling Positive Regulation Of Cell Communication Positive Regulation Of Signaling Phosphorylation Cytokine Activity Regulation Of Fibroblast Proliferation Protein Serine/threonine Kinase Activity Positive Regulation Of Cell Junction Assembly Regulation Of Intracellular Signal Transduction Regulation Of Cardiac Muscle Cell Action Potential	Macrophage Migration Inhibitory Factor Binding Identical Protein Binding T Cell Activation Involved In Immune Response Protein Deneddylation Metal-dependent Deubiquitinase Activity Regulation Of Fibroblast Proliferation Regulation Of Protein Neddylation Protein Neddylation Regulation Of Fatty Acid Biosynthetic Process Cytokine-mediated Signaling Pathway MHC Class II Protein Binding, Via Antigen Binding Groove Lymphocyte Activation Involved In Immune Response NOS2-CD74 Complex Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Macrophage Migration Inhibitory Factor Signaling Pathway Cell Activation Involved In Immune Response Regulation Of Protein Modification Process Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Regulation Of Protein Metabolic Process Antigen Processing And Presentation Of Exogenous Antigen Leukocyte Activation Involved In Immune Response B Cell Mediated Immunity Protein-containing Complex Antigen Processing And Presentation Of Exogenous Peptide Antigen Positive Regulation Of Myeloid Leukocyte Cytokine Production Involved In Immune Response Antigen Processing And Presentation Of Peptide Antigen Via MHC Class II Antigen Processing And Presentation Of Peptide Or Polysaccharide Antigen Via MHC Class II Immunoglobulin Mediated Immune Response Negative Regulation Of Stem Cell Proliferation Embryonic Organ Development Embryonic Placenta Development RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Multivesicular Body, Internal Vesicle Lumen Leukocyte Apoptotic Process IgE Receptor Activity Farnesyl Diphosphate Kinase Activity Succinyl-CoA Binding Protein Phosphatase 2A Binding Negative Regulation Of Helicase Activity Negative Regulation Of G1 To G0 Transition COP9 Signalosome Protein-N-terminal Glutamine Amidohydrolase Activity Nucleus Negative Regulation Of Apoptotic Process Antigen Processing And Presentation Of Peptide Antigen Positive Regulation Of Fibroblast Proliferation Regulation Of Lymphocyte Apoptotic Process Protein Complex Oligomerization Regulation Of Apoptotic Process
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