ASNS

Name	asparagine synthetase (glutamine-hydrolyzing)
Structure
Novel Interactors	1 novel interactors: RAB8A
Interactors	6 interactors: ATXN1 CEBPA STRN4 SUMO2 TRIM69 WDR27
GO Annotations	Cellular Component	Cytosol
	Molecular Function	Nucleotide Binding Asparagine Synthase (glutamine-hydrolyzing) Activity Protein Binding ATP Binding Ligase Activity
	Biological Process	Asparagine Biosynthetic Process Amino Acid Biosynthetic Process Cellular Response To Glucose Starvation Negative Regulation Of Apoptotic Process Positive Regulation Of Mitotic Cell Cycle L-asparagine Biosynthetic Process
Pathways	ATF4 activates genes in response to endoplasmic reticulum stress Aspartate and asparagine metabolism Response of EIF2AK4 (GCN2) to amino acid deficiency Response of EIF2AK1 (HRI) to heme deficiency
Drugs	Aspartic acid Glutamic acid ATP Asparagine
GWAS	Regular attendance at a religious group ( 29970889 ) Tuberculosis ( 30713548 )
Entrez ID	440
HPRD ID	00153
Ensembl ID	ENSG00000070669
Uniprot IDs	P08243
PDB IDs	6GQ3 8SUE 9B6C
GO Terms Enriched among Interactors ?	Postsynapse Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process CHOP-C/EBP Complex Nuclear Matrix Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Response To Vitamin B2 Memory C/EBP Complex Positive Regulation Of Proteasomal Protein Catabolic Process Golgi Vesicle Fusion To Target Membrane Glutamatergic Synapse GABA-ergic Synapse White Fat Cell Proliferation POZ Domain Binding