STRN4 and ASNS

Number of citations of the paper that reports this interaction (PubMedID 16169070)
0

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		STRN4	ASNS
Description		striatin 4	asparagine synthetase (glutamine-hydrolyzing)
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Dendrite Protein-containing Complex Neuronal Cell Body Dendritic Spine FAR/SIN/STRIPAK Complex Postsynapse Glutamatergic Synapse GABA-ergic Synapse	Cytosol
	Molecular Function	Protein Binding Calmodulin Binding Protein Domain Specific Binding Protein-macromolecule Adaptor Activity Protein-containing Complex Binding Protein Phosphatase 2A Binding Armadillo Repeat Domain Binding	Nucleotide Binding Asparagine Synthase (glutamine-hydrolyzing) Activity Protein Binding ATP Binding Ligase Activity
	Biological Process	Negative Regulation Of Hippo Signaling Regulation Of Modification Of Postsynaptic Structure	Asparagine Biosynthetic Process Amino Acid Biosynthetic Process Cellular Response To Glucose Starvation Negative Regulation Of Apoptotic Process Positive Regulation Of Mitotic Cell Cycle L-asparagine Biosynthetic Process
Pathways			ATF4 activates genes in response to endoplasmic reticulum stress Aspartate and asparagine metabolism Response of EIF2AK4 (GCN2) to amino acid deficiency Response of EIF2AK1 (HRI) to heme deficiency
Drugs			Aspartic acid Glutamic acid ATP Asparagine
Diseases
GWAS		Aspartate aminotransferase levels ( 33547301) Chronic lymphocytic leukemia ( 18758461 28165464) Primary sclerosing cholangitis ( 23603763)	Regular attendance at a religious group ( 29970889) Tuberculosis ( 30713548)
Interacting Genes		28 interacting genes: AK5 ASNS CALM1 CAV1 CLDN12 CRK DDX39B DFFA ECSIT GDF9 JUN KLHDC2 MAP4K1 MAP4K2 MAP4K3 MAP4K4 MIF MSANTD2 MTG1 NBEA PBDC1 PI4KA PLPPR3 PPBP SLC25A6 TNIK WIPI2 WNT7A	6 interacting genes: ATXN1 CEBPA STRN4 SUMO2 TRIM69 WDR27
Entrez ID		29888	440
HPRD ID		18125	00153
Ensembl ID		ENSG00000090372	ENSG00000070669
Uniprot IDs		F5GYK2 Q59GV6 Q9NRL3	P08243
PDB IDs			6GQ3 8SUE 9B6C
Enriched GO Terms of Interacting Partners?		MAP Kinase Kinase Kinase Kinase Activity MAPK Cascade Regulation Of MAPK Cascade JNK Cascade Regulation Of JNK Cascade Intracellular Signaling Cassette Positive Regulation Of MAPK Cascade Positive Regulation Of JNK Cascade Negative Regulation Of Apoptotic Process Positive Regulation Of Intracellular Signal Transduction Kinase Activity Intracellular Signal Transduction Negative Regulation Of Programmed Cell Death Positive Regulation Of Signal Transduction Regulation Of Cell Communication By Electrical Coupling Involved In Cardiac Conduction Cellular Response To Transforming Growth Factor Beta Stimulus Nucleotide Binding ATP Binding Response To Transforming Growth Factor Beta Protein Serine Kinase Activity Protein Phosphorylation Signal Transduction Regulation Of Cell Communication By Electrical Coupling Positive Regulation Of Cell Communication Positive Regulation Of Signaling Phosphorylation Cytokine Activity Regulation Of Fibroblast Proliferation Protein Serine/threonine Kinase Activity Positive Regulation Of Cell Junction Assembly Regulation Of Intracellular Signal Transduction Regulation Of Cardiac Muscle Cell Action Potential	Postsynapse Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process CHOP-C/EBP Complex Nuclear Matrix Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Response To Vitamin B2 Memory C/EBP Complex Positive Regulation Of Proteasomal Protein Catabolic Process Golgi Vesicle Fusion To Target Membrane Glutamatergic Synapse GABA-ergic Synapse White Fat Cell Proliferation POZ Domain Binding
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