MLLT6 and MED15

Number of citations of the paper that reports this interaction (PMID 16189514)
699

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		MLLT6	MED15
Gene Name		myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 6	mediator complex subunit 15
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus	Nucleus Nucleoplasm Cytoplasm Membrane Mediator Complex
	Molecular Function	Protein Binding Zinc Ion Binding	RNA Polymerase II Transcription Cofactor Activity Protein Binding
	Biological Process	Regulation Of Transcription, DNA-templated	Regulation Of Transcription From RNA Polymerase II Promoter Transcription Initiation From RNA Polymerase II Promoter Gene Expression Stem Cell Maintenance
Pathways			PPARA activates gene expression Fatty acid, triacylglycerol, and ketone body metabolism Metabolism of lipids and lipoproteins Generic Transcription Pathway Transcriptional regulation of white adipocyte differentiation Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
Drugs
Diseases
GWAS
Protein-Protein Interactions		20 interactors: APP CASK CEBPE CEBPG CEP44 CRX DOT1L ENOX2 IKBKG KRTAP10-8 MED15 MEOX2 SPRY2 TCF12 TCF4 UBE2G2 UBQLN1 UBQLN4 WHSC1L1 ZBTB22	12 interactors: ATP5C1 ATXN1 CTDP1 FHL3 MED25 MLLT6 PLSCR1 RELA SMAD2 SMAD3 TRIM11 UBC
Entrez ID		4302	51586
HPRD ID		08978	12117
Ensembl ID		ENSG00000108292	ENSG00000099917
Uniprot IDs		P55198	B4DGD6 G3V1P5 Q96RN5
PDB IDs			2GUT
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Gene Expression Positive Regulation Of Transcription, DNA-templated Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Transcription, DNA-templated Regulation Of Metabolic Process Positive Regulation Of Cellular Biosynthetic Process Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Transcription, DNA-templated Transcription From RNA Polymerase II Promoter RNA Biosynthetic Process RNA Metabolic Process Positive Regulation Of Cellular Metabolic Process Gene Expression Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Regulation Of Binding Positive Regulation Of Metabolic Process Negative Regulation Of Cellular Response To Growth Factor Stimulus Nitrogen Compound Metabolic Process Negative Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Organ Development Biosynthetic Process Regulation Of Cellular Response To Growth Factor Stimulus Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Growth Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Regulation Of Neuron Differentiation Regulation Of Cellular Process Regulation Of Protein Metabolic Process Ultradian Rhythm Histone H3-K79 Methylation Positive Regulation Of Photoreceptor Cell Differentiation Anatomical Structure Development Neuron Death Regulation Of Epidermal Growth Factor Receptor Signaling Pathway System Development Regulation Of Neurogenesis Synaptic Growth At Neuromuscular Junction Catenin Import Into Nucleus Canonical Wnt Signaling Pathway Involved In Positive Regulation Of Epithelial To Mesenchymal Transition	Transcription From RNA Polymerase II Promoter Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Transcription, DNA-templated Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Transcription Initiation From RNA Polymerase II Promoter Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Transcription, DNA-templated Primary MiRNA Processing RNA Biosynthetic Process DNA-templated Transcription, Initiation SMAD Protein Complex Assembly Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Gene Expression Positive Regulation Of Cellular Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Paraxial Mesoderm Morphogenesis Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Negative Regulation Of Cellular Response To Growth Factor Stimulus Negative Regulation Of Cellular Metabolic Process Regulation Of Transcription, DNA-templated Nodal Signaling Pathway Regulation Of Nucleic Acid-templated Transcription RNA Metabolic Process Embryonic Foregut Morphogenesis Foregut Morphogenesis Transforming Growth Factor Beta Receptor Signaling Pathway Paraxial Mesoderm Development Nucleobase-containing Compound Metabolic Process Positive Regulation Of Metabolic Process Production Of MiRNAs Involved In Gene Silencing By MiRNA Gene Expression Regulation Of Viral Process Positive Regulation Of Chondrocyte Differentiation Pericardium Development Defense Response To Virus Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Biosynthetic Process Nucleotide-binding Oligomerization Domain Containing Signaling Pathway
Tagcloud ?		abl1 aff1 cbfb cryptic cytogenetics dek ell etv6 fifteen inv mllt1 mllt10 mllt3 mllt4 mrt multiplex myh11 nup214 p13 pbx1 q23 rara runx1 runx1t1 simplified tcf3 translocations zbtb16	9aatad 9aatads alignment ambiguous analogy architecture belong cmyb differently e2a formations foxo3 gcn4 heb helical kix leucine mll oaf1 pdr1 plausible position requirements resolved shares shed structural tad transactivation
Tagcloud (Difference) ?		abl1 aff1 cbfb cryptic cytogenetics dek ell etv6 fifteen inv mllt1 mllt10 mllt3 mllt4 mrt multiplex myh11 nup214 p13 pbx1 q23 rara runx1 runx1t1 simplified tcf3 translocations zbtb16	9aatad 9aatads alignment ambiguous analogy architecture belong cmyb differently e2a formations foxo3 gcn4 heb helical kix leucine oaf1 pdr1 plausible position requirements resolved shares shed structural tad transactivation
Tagcloud (Intersection) ?		mll