TFEB and TFE3

Number of citations of the paper that reports this interaction (PubMedID 9806910)
0

Data Source:
HPRD (in vivo)

		TFEB	TFE3
Description		transcription factor EB	transcription factor binding to IGHM enhancer 3
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GO Annotations	Cellular Component	Chromatin Nucleus Transcription Regulator Complex Cytoplasm Lysosome Lysosomal Membrane Cytosol Membrane	Chromatin Nucleus Nucleoplasm Cytoplasm Lysosome Lysosomal Membrane Cytosol Membrane
	Molecular Function	Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Enzyme Binding Protein Heterodimerization Activity Protein Dimerization Activity Sequence-specific Double-stranded DNA Binding	Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Protein Dimerization Activity Sequence-specific Double-stranded DNA Binding
	Biological Process	Embryonic Placenta Development Adaptive Immune Response Immune System Process Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Autophagy Humoral Immune Response Lysosome Organization Cellular Response To Starvation Positive Regulation Of Autophagy Lysosome Localization Cellular Response To Amino Acid Starvation Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Defense Response To Gram-negative Bacterium Antibacterial Innate Immune Response Regulation Of Lysosome Organization	Adaptive Immune Response Immune System Process Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Humoral Immune Response Lysosome Organization Regulation Of Osteoclast Differentiation Positive Regulation Of Cell Adhesion Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Brown Fat Cell Differentiation Negative Regulation Of Cold-induced Thermogenesis
Pathways		Transcriptional and post-translational regulation of MITF-M expression and activity Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes	Transcriptional and post-translational regulation of MITF-M expression and activity
Drugs
Diseases			Alveolar soft part sarcoma Renal cell carcinoma
GWAS		Attention deficit hyperactivity disorder ( 18839057) Blood urea nitrogen levels ( 31152163) Colorectal cancer ( 26965516 30529582) Creatinine levels ( 29403010) Estimated glomerular filtration rate ( 31015462 31152163 31451708) Estimated glomerular filtration rate in non-diabetics ( 31451708) Late-onset Alzheimer's disease ( 27770636) PR interval ( 32439900) White blood cell count ( 32888494)
Interacting Genes		5 interacting genes: CFTR MITF SRPK1 TFE3 TFEC	12 interacting genes: BTRC E2F3 FBXW11 HMGB1 LAMTOR3 MITF SMAD3 SMAD4 SMARCE1 TFEB TFEC YWHAG
Entrez ID		7942	7030
HPRD ID		02847	02439
Ensembl ID		ENSG00000112561	ENSG00000068323
Uniprot IDs		B0QYS6 P19484	B4DIA5 P19532
PDB IDs		7UX2 7UXC 7UXH 7Y62	7F09
Enriched GO Terms of Interacting Partners?		Protein Dimerization Activity Lysosomal Membrane Intracellularly ATP-gated Chloride Channel Activity Positive Regulation Of Voltage-gated Chloride Channel Activity Sec61 Translocon Complex Binding Regulation Of Osteoclast Differentiation Chromatin DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Cellular Response To Interleukin-12 Positive Regulation Of Anion Channel Activity Melanocyte Apoptotic Process Regulation Of Myeloid Leukocyte Differentiation Positive Regulation Of Monoatomic Anion Transport Protein Binding Involved In Heterotypic Cell-cell Adhesion Response To Interleukin-12 Thrombospondin Receptor Activity Positive Regulation Of Enamel Mineralization Positive Regulation Of Monocyte Extravasation Transepithelial Water Transport ATP Export Fibrinogen Binding Positive Regulation Of Tooth Mineralization Chloride Channel Inhibitor Activity Chloride Channel Regulator Activity Regulation Of Enamel Mineralization Membrane Hyperpolarization Regulation Of Myeloid Cell Differentiation Bicarbonate Transmembrane Transporter Activity Intracellular PH Elevation Amelogenesis RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding ATPase-coupled Inorganic Anion Transmembrane Transporter Activity DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific Regulation Of Fc Receptor Mediated Stimulatory Signaling Pathway	Protein Dimerization Activity Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Biosynthetic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Metabolic Process DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Chromatin Regulation Of Transcription By RNA Polymerase II Regulation Of RNA Metabolic Process Regulation Of Gene Expression Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of DNA-templated Transcription SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Primary Metabolic Process SMAD Protein Complex Regulation Of Nucleobase-containing Compound Metabolic Process TORC1 Signaling Heteromeric SMAD Protein Complex Regulation Of Transforming Growth Factor Beta2 Production Negative Regulation Of RNA Metabolic Process DNA Binding Transcription Regulator Complex Positive Regulation Of Extracellular Matrix Assembly Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Macromolecule Biosynthetic Process RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Negative Regulation Of Nucleobase-containing Compound Metabolic Process Transcription Cis-regulatory Region Binding TOR Signaling Negative Regulation Of Biosynthetic Process Regulation Of Macromolecule Metabolic Process Positive Regulation Of Signal Transduction Regulation Of TORC1 Signaling DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity Regulation Of T Cell Mediated Immune Response To Tumor Cell Positive Regulation Of Intracellular Signal Transduction I-SMAD Binding Positive Regulation Of Cell Communication Positive Regulation Of Signaling Negative Regulation Of Macromolecule Metabolic Process Regulation Of Metabolic Process
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