HINT1 and TRIM29

Number of citations of the paper that reports this interaction (PubMedID 7644499)
42

Data Source:
HPRD (in vitro)

		HINT1	TRIM29
Description		histidine triad nucleotide binding protein 1	tripartite motif containing 29
Image
GO Annotations	Cellular Component	Histone Deacetylase Complex Nucleus Nucleoplasm Cytoplasm Cytosol Cytoskeleton Plasma Membrane Extracellular Exosome	Cytoplasm Lysosome Adherens Junction
	Molecular Function	Nucleotide Binding Catalytic Activity Protein Kinase C Binding Protein Binding Peptidase Activity Cysteine-type Peptidase Activity Hydrolase Activity DeSUMOylase Activity Adenosine 5'-monophosphoramidase Activity	P53 Binding Protein Binding Zinc Ion Binding Identical Protein Binding Metal Ion Binding Cadherin Binding Involved In Cell-cell Adhesion
	Biological Process	Regulation Of DNA-templated Transcription Proteolysis Apoptotic Process Signal Transduction Purine Ribonucleotide Catabolic Process Protein Desumoylation Positive Regulation Of Calcium-mediated Signaling Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator	Negative Regulation Of Transcription By RNA Polymerase II Immune System Process Innate Immune Response Cell-cell Adhesion Negative Regulation Of Protein Localization To Nucleus
Pathways		Regulation of MITF-M-dependent genes involved in apoptosis Regulation of MITF-M-dependent genes involved in cell cycle and proliferation Transcriptional and post-translational regulation of MITF-M expression and activity	Interferon gamma signaling
Drugs		Adenosine phosphate Guanosine-5'-Monophosphate 5'-O-(N-Ethyl-Sulfamoyl)Adenosine Adenosine-5'-ditungstate 8-Bromo-Adenosine-5'-Monophosphate
Diseases
GWAS		Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Crohn's disease ( 28067908) Inflammatory bowel disease ( 28067908) Subcortical volume (MOSTest) ( 32665545) Ulcerative colitis ( 28067908)	Corneal curvature ( 22969067) Disease progression in age-related macular degeneration (adjusted for baseline) ( 29346644) Resistance to antihypertensive treatment in hypertension ( 31545351) Retinal detachment or retinal break ( 31816047) Stroke (pediatric) ( 22990015)
Interacting Genes		9 interacting genes: CDC16 CPSF7 ERBB3 MITF RGS17 RGS19 SP1 TRIM29 USP40	55 interacting genes: ACTN3 ANKS1A ATM CARD9 CCDC57 CDC34 CEP70 CRACR2A DISC1 DMRT1 FBF1 FBXL19 FXR2 GATA1 GCC1 GOLGA2 GTF2E1 H4C1 HCLS1 HDAC9 HINT1 IKBKG JAKMIP2 KAT5 KRT35 LZTS2 MAD1L1 MAPKAPK2 MED7 MID2 MLH1 MSH2 MTUS2 MYO15B NFKBID POLR2D POLR2E PRICKLE3 PRKCA RNF13 RNF8 SHOX2 SMAD9 SNAPC1 SP100 TAX1BP3 TRIM11 TRIM23 TRIM27 TRIP6 TSGA10 UBE2C UBE2E1 UBE2I VIM
Entrez ID		3094	23650
HPRD ID		03204	10280
Ensembl ID		ENSG00000169567	ENSG00000137699
Uniprot IDs		A0A384NPU2 D6RD60 P49773	B7Z5V5 B7Z8U9 E9PRL4 Q14134
PDB IDs		1AV5 1KPA 1KPB 1KPC 1KPE 1KPF 3TW2 4EQE 4EQG 4EQH 4ZKL 4ZKV 5ED3 5ED6 5EMT 5I2E 5I2F 5IPB 5IPC 5IPD 5IPE 5KLY 5KLZ 5KM0 5KM1 5KM2 5KM3 5KM4 5KM6 5KMA 5KMB 5KMC 5O8I 5WA8 5WA9 5WAA 6B42 6G9Z 6J53 6J58 6J5S 6J5Z 6J64 6J65 6N3V 6N3W 6N3X 6N3Y 6YQM 7Q2U 8P8P 8PA6 8PA9 8PAF 8PAI 8PWK 8WZD	2CSV
Enriched GO Terms of Interacting Partners?			Negative Regulation Of Viral Transcription Protein Modification By Small Protein Conjugation Post-translational Protein Modification Ubiquitin-protein Transferase Activity Nucleus Cytoskeleton Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Regulation Of Viral Transcription Regulation Of Skeletal Muscle Fiber Development Protein Ubiquitination Positive Regulation Of DNA Recombination Cytosol Positive Regulation Of Metabolic Process Proteolysis Involved In Protein Catabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Cell Development Somatic Cell DNA Recombination Cytoplasm Ubiquitin Protein Ligase Activity Positive Regulation Of Autophagy Positive Regulation Of Macromolecule Metabolic Process Negative Regulation Of DNA Recombination Signal Transduction By P53 Class Mediator Suppression Of Viral Release By Host Negative Regulation Of Nucleobase-containing Compound Metabolic Process Ubiquitin Ligase Complex Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process Intracellular Signal Transduction Double-strand Break Repair Via Nonhomologous End Joining Nucleoplasm Protein Modification Process Guanine/thymine Mispair Binding Positive Regulation Of Biosynthetic Process Isotype Switching Somatic Recombination Of Immunoglobulin Genes Involved In Immune Response Positive Regulation Of Catabolic Process Protein Localization To Site Of Double-strand Break Positive Regulation Of Cell Development Regulation Of DNA Recombination Somatic Diversification Of Immunoglobulins Involved In Immune Response Regulation Of RNA Metabolic Process Negative Regulation Of Viral Process Macromolecule Catabolic Process Identical Protein Binding Protein Binding Signal Transduction In Response To DNA Damage Transcription Regulator Complex Positive Regulation Of Isotype Switching To IgA Isotypes
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