TFEC and TFE3

Number of citations of the paper that reports this interaction (PubMedID 8336698)
49

Data Source:
HPRD (in vitro)

		TFEC	TFE3
Description		transcription factor EC	transcription factor binding to IGHM enhancer 3
Image		No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Cytosol	Chromatin Nucleus Nucleoplasm Cytoplasm Lysosome Lysosomal Membrane Cytosol Membrane
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Protein Binding Protein Dimerization Activity Sequence-specific Double-stranded DNA Binding	Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Protein Dimerization Activity Sequence-specific Double-stranded DNA Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Cellular Response To Heat Positive Regulation Of Transcription By RNA Polymerase II	Adaptive Immune Response Immune System Process Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Humoral Immune Response Lysosome Organization Regulation Of Osteoclast Differentiation Positive Regulation Of Cell Adhesion Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Brown Fat Cell Differentiation Negative Regulation Of Cold-induced Thermogenesis
Pathways		Transcriptional and post-translational regulation of MITF-M expression and activity	Transcriptional and post-translational regulation of MITF-M expression and activity
Drugs
Diseases			Alveolar soft part sarcoma Renal cell carcinoma
GWAS		Body mass index ( 28892062) Chronotype ( 30696823) General risk tolerance (MTAG) ( 30643258) Heel bone mineral density x serum urate levels interaction ( 34046847) Height ( 28552196) Intraocular pressure ( 29235454 29617998 29785010) Number of sexual partners ( 30643258) Platelet distribution width ( 32888494) Plateletcrit ( 32888494) Proportion of activated microglia (inferior temporal cortex) ( 30679421) Schizophrenia, bipolar disorder or major depressive disorder ( 34099189) Schizophrenia, bipolar disorder or major depressive disorder x sex interaction ( 34099189) Schizophrenia, bipolar disorder or recurrent major depressive disorder x sex interaction ( 34099189) Tonsillectomy ( 27182965 28928442)
Interacting Genes		11 interacting genes: DCK DEFB127 HNRNPA1 LPAR3 MITF NAPB SMCO4 TET2 TFE3 TFEB ZMAT2	12 interacting genes: BTRC E2F3 FBXW11 HMGB1 LAMTOR3 MITF SMAD3 SMAD4 SMARCE1 TFEB TFEC YWHAG
Entrez ID		22797	7030
HPRD ID		05294	02439
Ensembl ID		ENSG00000105967	ENSG00000068323
Uniprot IDs		O14948	B4DIA5 P19532
PDB IDs			7F09
Enriched GO Terms of Interacting Partners?		Deoxyguanosine Kinase Activity Deoxynucleoside Kinase Activity Deoxyadenosine Kinase Activity Deoxycytidine Kinase Activity DAMP Salvage Telomeric Repeat-containing RNA Binding DNA Binding Protein Dimerization Activity Melanocyte Apoptotic Process Lysosomal Membrane Regulation Of Osteoclast Differentiation Lysosome Organization Humoral Immune Response Defense Response To Gram-negative Bacterium DNA 5-methylcytosine Dioxygenase Activity Soluble NSF Attachment Protein Activity SNARE Complex Disassembly Cytidine Kinase Activity CMP Biosynthetic Process DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Lysophosphatidic Acid Receptor Activity Synaptobrevin 2-SNAP-25-syntaxin-1a Complex Regulation Of Myeloid Leukocyte Differentiation Cellular Response To Sodium Arsenite Lysosome	Protein Dimerization Activity Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Biosynthetic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Metabolic Process DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Chromatin Regulation Of Transcription By RNA Polymerase II Regulation Of RNA Metabolic Process Regulation Of Gene Expression Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of DNA-templated Transcription SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Primary Metabolic Process SMAD Protein Complex Regulation Of Nucleobase-containing Compound Metabolic Process TORC1 Signaling Heteromeric SMAD Protein Complex Regulation Of Transforming Growth Factor Beta2 Production Negative Regulation Of RNA Metabolic Process DNA Binding Transcription Regulator Complex Positive Regulation Of Extracellular Matrix Assembly Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Macromolecule Biosynthetic Process RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Negative Regulation Of Nucleobase-containing Compound Metabolic Process Transcription Cis-regulatory Region Binding TOR Signaling Negative Regulation Of Biosynthetic Process Regulation Of Macromolecule Metabolic Process Positive Regulation Of Signal Transduction Regulation Of TORC1 Signaling DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity Regulation Of T Cell Mediated Immune Response To Tumor Cell Positive Regulation Of Intracellular Signal Transduction I-SMAD Binding Positive Regulation Of Cell Communication Positive Regulation Of Signaling Negative Regulation Of Macromolecule Metabolic Process Regulation Of Metabolic Process
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