TFEC and SMCO4

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		TFEC	SMCO4
Description		transcription factor EC	single-pass membrane protein with coiled-coil domains 4
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Cytosol	Membrane
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Protein Binding Protein Dimerization Activity Sequence-specific Double-stranded DNA Binding	Protein Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Cellular Response To Heat Positive Regulation Of Transcription By RNA Polymerase II
Pathways		Transcriptional and post-translational regulation of MITF-M expression and activity
Drugs
Diseases
GWAS		Body mass index ( 28892062) Chronotype ( 30696823) General risk tolerance (MTAG) ( 30643258) Heel bone mineral density x serum urate levels interaction ( 34046847) Height ( 28552196) Intraocular pressure ( 29235454 29617998 29785010) Number of sexual partners ( 30643258) Platelet distribution width ( 32888494) Plateletcrit ( 32888494) Proportion of activated microglia (inferior temporal cortex) ( 30679421) Schizophrenia, bipolar disorder or major depressive disorder ( 34099189) Schizophrenia, bipolar disorder or major depressive disorder x sex interaction ( 34099189) Schizophrenia, bipolar disorder or recurrent major depressive disorder x sex interaction ( 34099189) Tonsillectomy ( 27182965 28928442)	Adult body size ( 32376654) Insulin levels in response to oral glucose tolerance test (30 minutes) ( 29093273) Liver enzyme levels (alanine transaminase) ( 33972514)
Interacting Genes		11 interacting genes: DCK DEFB127 HNRNPA1 LPAR3 MITF NAPB SMCO4 TET2 TFE3 TFEB ZMAT2	62 interacting genes: AQP6 ARL13B BNIP3L CD79A CLEC10A CLTRN CPLX4 CREB3L1 CXCR2 EBP ELOVL4 ERGIC3 FAM174A FAM209A FAM210B FFAR2 GJA8 GKN1 GPA33 GPR152 GPR42 HHLA2 ICAM3 IL10RA KASH5 KCNK5 KIR3DL1 KRT40 KRTAP10-3 KRTAP10-7 LEPROTL1 LMNA LRRC25 M6PR MGST3 MS4A3 MUC1 PEX12 PLD3 PTGES RETREG3 SCN3B SLC10A6 SLC16A2 SLC18A1 SLC35H1 SLC41A3 SLC7A1 SLC7A14 SMIM3 SPINT1 STOM SUSD3 SYNE4 SYNPR TEX29 TFEC TMEM139 TMEM80 TMX2 VSIR WBP1
Entrez ID		22797	56935
HPRD ID		05294	17008
Ensembl ID		ENSG00000105967	ENSG00000166002
Uniprot IDs		O14948	Q9NRQ5
PDB IDs
Enriched GO Terms of Interacting Partners?		Deoxyguanosine Kinase Activity Deoxynucleoside Kinase Activity Deoxyadenosine Kinase Activity Deoxycytidine Kinase Activity DAMP Salvage Telomeric Repeat-containing RNA Binding DNA Binding Protein Dimerization Activity Melanocyte Apoptotic Process Lysosomal Membrane Regulation Of Osteoclast Differentiation Lysosome Organization Humoral Immune Response Defense Response To Gram-negative Bacterium DNA 5-methylcytosine Dioxygenase Activity Soluble NSF Attachment Protein Activity SNARE Complex Disassembly Cytidine Kinase Activity CMP Biosynthetic Process DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Lysophosphatidic Acid Receptor Activity Synaptobrevin 2-SNAP-25-syntaxin-1a Complex Regulation Of Myeloid Leukocyte Differentiation Cellular Response To Sodium Arsenite Lysosome	Membrane Protein Binding
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