METTL1 and WDR4

Number of citations of the paper that reports this interaction (PubMedID 33961781)
97

Data Source:
BioGRID (affinity chromatography technology, x-ray crystallography, x-ray crystallography)
HPRD (in vivo, two hybrid)

		METTL1	WDR4
Description		methyltransferase 1, tRNA methylguanosine	WDR4 tRNA N7-guanosine methyltransferase non-catalytic subunit
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Cytosol TRNA Methyltransferase Complex TRNA (m7G46) Methyltransferase Complex	Nucleus Nucleoplasm Chromosome Cytosol TRNA Methyltransferase Complex TRNA (m7G46) Methyltransferase Complex
	Molecular Function	TRNA Binding RNA Binding Protein Binding Methyltransferase Activity TRNA (guanine(46)-N7)-methyltransferase Activity Transferase Activity Internal MRNA (guanine-N7-)-methyltransferase Activity	Protein Binding Enzyme Activator Activity TRNA Methyltransferase Activator Activity
	Biological Process	TRNA Modification TRNA Processing Intracellular MRNA Localization TRNA Methylation Methylation Cellular Response To Stress Stress Granule Assembly RNA (guanine-N7)-methylation TRNA Stabilization MRNA Transport TRNA (guanine-N7)-methylation	TRNA Modification DNA Damage Response TRNA Processing RNA (guanine-N7)-methylation TRNA Stabilization TRNA (guanine-N7)-methylation
Pathways		tRNA modification in the nucleus and cytosol	tRNA modification in the nucleus and cytosol
Drugs
Diseases
GWAS		Brain morphology (MOSTest) ( 32665545) Multiple sclerosis ( 19525955) Waist circumference adjusted for body mass index ( 34021172)	Blood and toenail selenium levels ( 25343990) Fasting plasma glucose ( 28270201)
Interacting Genes		3 interacting genes: AKT1 RPS6KA1 WDR4	18 interacting genes: CADPS2 CAPZA2 CDC42BPB COPS5 FAM118A FEN1 HLA-DRA METTL1 PAX6 PTPN23 RABGGTB REV3L SF3B4 TERF1 TERF2 UBE3A ZMYND8 ZNF84
Entrez ID		4234	10785
HPRD ID		06834	09330
Ensembl ID		ENSG00000037897	ENSG00000160193
Uniprot IDs		Q9UBP6	P57081
PDB IDs		3CKK 7OGJ 7PL1 7U20 8CTH 8CTI 8D58 8D59 8D5B 8D9K 8D9L 8EG0 8H0N	7U20 8CTH 8CTI 8D58 8D9K 8D9L 8EG0 8H0N
Enriched GO Terms of Interacting Partners?		TRNA (guanine-N7)-methylation TRNA Stabilization RNA (guanine-N7)-methylation Protein Serine/threonine/tyrosine Kinase Activity TRNA Methylation Post-transcriptional Regulation Of Gene Expression TORC1 Signaling RNA Methylation RNA Stabilization TOR Signaling TRNA Modification Negative Regulation Of TOR Signaling Negative Regulation Of RNA Catabolic Process Macromolecule Methylation TRNA Processing Regulation Of TRNA Methylation Regulation Of TOR Signaling Positive Regulation Of Cell Growth RNA Modification Negative Regulation Of Protein Localization To Lysosome TRNA Methyltransferase Activator Activity TRNA (m7G46) Methyltransferase Complex TRNA Metabolic Process Methylation Positive Regulation Of Protein Localization To Endoplasmic Reticulum Response To Insulin-like Growth Factor Stimulus Mammalian Oogenesis Stage Regulation Of RNA Stability Cellular Response To Rapamycin Negative Regulation Of Hydrogen Peroxide-induced Neuron Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Endodeoxyribonuclease Activity Positive Regulation Of Growth Negative Regulation Of Long-chain Fatty Acid Import Across Plasma Membrane TORC2 Complex Binding Positive Regulation Of Deoxyribonuclease Activity Positive Regulation Of Anaphase-promoting Complex-dependent Catabolic Process SREBP-SCAP Complex Retention In Endoplasmic Reticulum Negative Regulation Of SREBP Signaling Pathway Negative Regulation Of Fatty Acid Beta-oxidation Beta-arrestin-dependent Dopamine Receptor Signaling Pathway Maintenance Of Protein Location In Mitochondrion Positive Regulation Of Hepatic Stellate Cell Activation Response To Rapamycin Regulation Of Anaphase-promoting Complex-dependent Catabolic Process Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To Hydrogen Peroxide Potassium Channel Activator Activity Protein Phosphorylation Activation-induced Cell Death Of T Cells Regulation Of Endodeoxyribonuclease Activity Positive Regulation Of Toll-like Receptor Signaling Pathway	Negative Regulation Of Telomeric D-loop Disassembly Negative Regulation Of Telomere Maintenance Via Semi-conservative Replication Shelterin Complex Telomerase Activity Nuclear Telomere Cap Complex Telomeric D-loop Disassembly Double-stranded Telomeric DNA Binding G-rich Strand Telomeric DNA Binding Telomeric Loop Disassembly Telomere Capping DNA Biosynthetic Process Macromolecule Metabolic Process Telomere Maintenance Positive Regulation Of Chromosome Organization Negative Regulation Of Telomere Maintenance Via Telomerase Telomere Organization RNA-templated DNA Biosynthetic Process Double-strand Break Repair Via Homologous Recombination Recombinational Repair Telomeric DNA Binding Negative Regulation Of Telomere Maintenance Via Telomere Lengthening Negative Regulation Of DNA Biosynthetic Process Nucleic Acid Metabolic Process Nucleoplasm DNA Metabolic Process Chromosome, Telomeric Region Internal MRNA (guanine-N7-)-methyltransferase Activity TRNA (guanine(46)-N7)-methyltransferase Activity Forebrain-midbrain Boundary Formation Pancreatic A Cell Development Regulation Of Telomere Maintenance Via Telomerase Negative Regulation Of Establishment Of Protein Localization To Telomere Negative Regulation Of Establishment Of Protein-containing Complex Localization To Telomere Negative Regulation Of Telomere Maintenance Negative Regulation Of Establishment Of RNA Localization To Telomere Positive Regulation Of Shelterin Complex Assembly Telomere Cap Complex Negative Regulation Of Telomere Maintenance Via Recombination Axonal Transport Of Messenger Ribonucleoprotein Complex Negative Regulation Of Telomere Single Strand Break Repair Sperm Entry Positive Regulation Of Golgi Lumen Acidification Positive Regulation Of Homophilic Cell Adhesion Organelle Localization Regulation Of Telomere Maintenance Via Telomere Lengthening Double-strand Break Repair Double-stranded DNA Exodeoxyribonuclease Activity Regulation Of Chromosome Organization Flap Endonuclease Activity DNA Recombination
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