METTL1

Description		methyltransferase 1, tRNA methylguanosine
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Cytosol TRNA Methyltransferase Complex TRNA (m7G46) Methyltransferase Complex
	Molecular Function	TRNA Binding RNA Binding Protein Binding Methyltransferase Activity TRNA (guanine(46)-N7)-methyltransferase Activity Transferase Activity Internal MRNA (guanine-N7-)-methyltransferase Activity
	Biological Process	TRNA Modification TRNA Processing Intracellular MRNA Localization TRNA Methylation Methylation Cellular Response To Stress Stress Granule Assembly RNA (guanine-N7)-methylation TRNA Stabilization MRNA Transport TRNA (guanine-N7)-methylation
Pathways		tRNA modification in the nucleus and cytosol
Drugs
Diseases
GWAS		Brain morphology (MOSTest) ( 32665545) Multiple sclerosis ( 19525955) Waist circumference adjusted for body mass index ( 34021172)
Interacting Genes		3 interacting genes: AKT1 RPS6KA1 WDR4
Entrez ID		4234
HPRD ID		06834
Ensembl ID		ENSG00000037897
Uniprot IDs		Q9UBP6
PDB IDs		3CKK 7OGJ 7PL1 7U20 8CTH 8CTI 8D58 8D59 8D5B 8D9K 8D9L 8EG0 8H0N
Enriched GO Terms of Interacting Partners?		TRNA (guanine-N7)-methylation TRNA Stabilization RNA (guanine-N7)-methylation Protein Serine/threonine/tyrosine Kinase Activity TRNA Methylation Post-transcriptional Regulation Of Gene Expression TORC1 Signaling RNA Methylation RNA Stabilization TOR Signaling TRNA Modification Negative Regulation Of TOR Signaling Negative Regulation Of RNA Catabolic Process Macromolecule Methylation TRNA Processing Regulation Of TRNA Methylation Regulation Of TOR Signaling Positive Regulation Of Cell Growth RNA Modification Negative Regulation Of Protein Localization To Lysosome TRNA Methyltransferase Activator Activity TRNA (m7G46) Methyltransferase Complex TRNA Metabolic Process Methylation Positive Regulation Of Protein Localization To Endoplasmic Reticulum Response To Insulin-like Growth Factor Stimulus Mammalian Oogenesis Stage Regulation Of RNA Stability Cellular Response To Rapamycin Negative Regulation Of Hydrogen Peroxide-induced Neuron Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Endodeoxyribonuclease Activity Positive Regulation Of Growth Negative Regulation Of Long-chain Fatty Acid Import Across Plasma Membrane TORC2 Complex Binding Positive Regulation Of Deoxyribonuclease Activity Positive Regulation Of Anaphase-promoting Complex-dependent Catabolic Process SREBP-SCAP Complex Retention In Endoplasmic Reticulum Negative Regulation Of SREBP Signaling Pathway Negative Regulation Of Fatty Acid Beta-oxidation Beta-arrestin-dependent Dopamine Receptor Signaling Pathway Maintenance Of Protein Location In Mitochondrion Positive Regulation Of Hepatic Stellate Cell Activation Response To Rapamycin Regulation Of Anaphase-promoting Complex-dependent Catabolic Process Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To Hydrogen Peroxide Potassium Channel Activator Activity Protein Phosphorylation Activation-induced Cell Death Of T Cells Regulation Of Endodeoxyribonuclease Activity Positive Regulation Of Toll-like Receptor Signaling Pathway
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