Wiki-Pi
About
Search
People
Updates
Search
FGFR4
Description
fibroblast growth factor receptor 4
Image
GO Annotations
Cellular Component
Extracellular Region
Endosome
Endoplasmic Reticulum
Golgi Apparatus
Plasma Membrane
Cell-cell Junction
Membrane
Transport Vesicle
Receptor Complex
Molecular Function
Nucleotide Binding
Protein Kinase Activity
Protein Tyrosine Kinase Activity
Transmembrane Receptor Protein Tyrosine Kinase Activity
Fibroblast Growth Factor Receptor Activity
Protein Binding
ATP Binding
Heparin Binding
Kinase Activity
Transferase Activity
Fibroblast Growth Factor Binding
Biological Process
Positive Regulation Of Cell Population Proliferation
Fibroblast Growth Factor Receptor Signaling Pathway
Regulation Of Gene Expression
Positive Regulation Of Gene Expression
Regulation Of Extracellular Matrix Disassembly
Cell Migration
Peptidyl-tyrosine Phosphorylation
Regulation Of Lipid Metabolic Process
Glucose Homeostasis
Cholesterol Homeostasis
Positive Regulation Of Catalytic Activity
Positive Regulation Of MAPK Cascade
Positive Regulation Of Proteolysis
Protein Autophosphorylation
Phosphate Ion Homeostasis
Positive Regulation Of ERK1 And ERK2 Cascade
Regulation Of Bile Acid Biosynthetic Process
Response To Bile Acid
Positive Regulation Of DNA Biosynthetic Process
Pathways
PI3K Cascade
PIP3 activates AKT signaling
betaKlotho-mediated ligand binding
FGFR4 mutant receptor activation
FGFR4 ligand binding and activation
Constitutive Signaling by Aberrant PI3K in Cancer
Phospholipase C-mediated cascade; FGFR4
FRS-mediated FGFR4 signaling
SHC-mediated cascade:FGFR4
PI-3K cascade:FGFR4
Negative regulation of FGFR4 signaling
Signaling by FGFR4 in disease
RAF/MAP kinase cascade
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
Drugs
Heparin
Ponatinib
Lenvatinib
Infigratinib
Erdafitinib
Pemigatinib
Futibatinib
Diseases
GWAS
A body shape index (
34021172
)
Activated partial thromboplastin time (
22703881
)
Apolipoprotein A1 levels (
32203549
)
Appendicular lean mass (
33097823
)
Body fat distribution (arm fat ratio) (
30664634
)
Body fat distribution (trunk fat ratio) (
30664634
)
Circulating fibroblast growth factor 23 levels (
30217807
)
Height (
25282103
31562340
28552196
)
Hemoglobin levels (
32327693
)
Hip circumference adjusted for BMI (
34021172
)
Hip index (
34021172
)
Hip shape (DXA scan) (
30320955
)
Narrowest width of the femoral neck (
30888730
)
Nonsyndromic cleft lip (
31609978
)
Type 2 diabetes (
30718926
32499647
)
Waist circumference adjusted for BMI (adjusted for smoking behaviour) (
28443625
)
Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction) (
28448500
)
Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction) (
28443625
)
Waist circumference adjusted for BMI in active individuals (
28448500
)
Waist circumference adjusted for BMI in non-smokers (
28443625
)
Waist circumference adjusted for BMI in smokers (
28443625
)
Waist circumference adjusted for body mass index (
28448500
34021172
25673412
)
Waist-hip index (
34021172
)
Waist-to-hip ratio adjusted for BMI (
34021172
26426971
)
Waist-to-hip ratio adjusted for BMI (additive genetic model) (
30778226
)
Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour) (
28443625
)
Waist-to-hip ratio adjusted for BMI (age <50) (
26426971
)
Waist-to-hip ratio adjusted for BMI (joint analysis main effects and smoking interaction) (
28443625
)
Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) (
26426971
)
Waist-to-hip ratio adjusted for body mass index (
25673412
26785701
)
Novel Interacting Genes
2 novel interacting genes:
IFT80
STC2
Interacting Genes
82 interacting genes:
ABCB5
AKT1
ANGPTL4
ARAF
ARNT
BECN1
BLID
CASC3
CBLC
CCND2
CCNE1
CD44
CDH2
CDK4
CDK6
CDKN2A
CDKN2B
CDKN2C
DIRAS3
EPHA4
EPSTI1
ERBB2
ERRFI1
FGF1
FGF17
FGF18
FGF19
FGF2
FGF3
FGF4
FGF5
FGF6
FGF7
FGF8
FGF9
FZR1
GLCE
GLIS2
GRM1
HGF
HIF1A
IGF1R
KDELR2
LATS2
LRATD2
MAP2K5
MAP2K6
MAP3K5
MAPK14
MDM4
MET
MSH2
MTA3
MYC
NF2
NSD3
OSGIN1
PDLIM2
PLCG1
PPP3CA
PSMC3IP
PTPN11
PTPN12
PTPN6
PTPRR
RAF1
RASL10B
RASSF1
RNF20
ROS1
SCGB3A1
SNCA
STAT1
STAT3
STK11
TEAD2
TERT
THRSP
TP53
TSC1
TTYH2
WIF1
Entrez ID
2264
HPRD ID
00625
Ensembl ID
ENSG00000160867
Uniprot IDs
B4DVP5
J3KPQ0
P22455
PDB IDs
4QQ5
4QQC
4QQJ
4QQT
4QRC
4R6V
4TYE
4TYG
4TYI
4TYJ
4UXQ
4XCU
5JKG
5NUD
5NWZ
5XFF
5XFJ
6IUO
6IUP
6J6Y
6JPE
6JPJ
6NVG
6NVH
6NVI
6NVJ
6NVK
6V9C
6YI8
7DTZ
7F3M
7N1J
7TYD
7V29
7VJL
7WCT
7WCW
7WCX
7YBO
7YBP
7YBX
7YC1
7YC3
7YSW
8KH6
8KH7
8KH8
8KH9
8W5C
8XLQ
Enriched GO Terms of Interacting Partners
?
Regulation Of Cell Population Proliferation
Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway
Positive Regulation Of Cell Population Proliferation
Enzyme-linked Receptor Protein Signaling Pathway
Regulation Of Intracellular Signal Transduction
Regulation Of MAPK Cascade
Regulation Of Signal Transduction
Fibroblast Growth Factor Receptor Signaling Pathway
Signal Transduction
Positive Regulation Of Cell Communication
Positive Regulation Of Signaling
Positive Regulation Of Signal Transduction
Regulation Of Cell Communication
Regulation Of Signaling
Positive Regulation Of Intracellular Signal Transduction
Regulation Of Epithelial Cell Proliferation
Cell Differentiation
Positive Regulation Of MAPK Cascade
Cell Surface Receptor Signaling Pathway
Cellular Developmental Process
Cell Population Proliferation
Regulation Of Cell Cycle
Regulation Of Locomotion
Neurogenesis
Intracellular Signal Transduction
Negative Regulation Of Signaling
Regulation Of Cell Motility
Negative Regulation Of Cell Communication
Growth Factor Activity
Negative Regulation Of Signal Transduction
Regulation Of Cell Migration
Regulation Of Programmed Cell Death
Fibroblast Growth Factor Receptor Binding
Intracellular Signaling Cassette
Animal Organ Development
Regulation Of Apoptotic Process
Developmental Process
Regulation Of Developmental Process
Negative Regulation Of Programmed Cell Death
Negative Regulation Of Apoptotic Process
Positive Regulation Of Epithelial Cell Proliferation
Regulation Of Phosphorus Metabolic Process
Regulation Of Cell Cycle Phase Transition
Protein Kinase Binding
Epithelial Cell Proliferation
Regulation Of Cell Differentiation
Regulation Of ERK1 And ERK2 Cascade
MAPK Cascade
Positive Regulation Of Macromolecule Metabolic Process
Positive Regulation Of Metabolic Process
Tagcloud
?