BORCS8-MEF2B and TEAD1

Number of citations: 61 (PubMedID 12861002)
Data Source: HPRD (in vitro)

		BORCS8-MEF2B	TEAD1
Name		BORCS8-MEF2B readthrough	TEA domain transcription factor 1
Structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Transcription Regulator Complex Cytosol Cell Junction	Chromatin Nucleus Nucleoplasm Transcription Regulator Complex TEAD-YAP Complex
	Molecular Function	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Histone Deacetylase Binding Protein Dimerization Activity Sequence-specific Double-stranded DNA Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Heart Development Muscle Organ Development Cell Differentiation Positive Regulation Of Transcription By RNA Polymerase II Animal Organ Development	Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Cell Growth Hippo Signaling Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Embryonic Organ Development Protein-containing Complex Assembly Positive Regulation Of MiRNA Transcription
Pathways		Myogenesis	YAP1- and WWTR1 (TAZ)-stimulated gene expression RUNX3 regulates YAP1-mediated transcription EGR2 and SOX10-mediated initiation of Schwann cell myelination Regulation of PD-L1(CD274) transcription
GWAS		Height ( 28552196 ) Schizophrenia ( 34099189 ) Schizophrenia x sex interaction ( 34099189 )	Age at first sexual intercourse ( 34211149 ) Central retinal vein equivalent ( 26567291 ) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203 ) Diisocyanate-induced asthma ( 25918132 ) Gut microbiota relative abundance (unclassified genus belonging to family Erysipelotrichaceae) ( 33208821 ) HDL cholesterol levels x loop diuretics use interaction ( 31806883 ) Heel bone mineral density ( 30598549 ) Height ( 20881960 25282103 28552196 ) Hip circumference adjusted for BMI ( 34021172 ) HOMA-B (corrected for HOMA-IR) ( 30369944 ) Household income (MTAG) ( 31844048 ) Intelligence (MTAG) ( 29326435 ) Neutrophil count ( 32888494 ) Rheumatic heart disease ( 34106200 )
Novel Interactors		1 novel interactors: GDF15	None recorded
Interacting Genes		9 interacting genes: AGR2 CABIN1 CTAG1A CTAG1B HDAC4 MESD TEAD1 TEKT4 TEX11	20 interacting genes: BORCS8-MEF2B ENO1 GCAT HLA-DMB INSR MAX MEF2A MEF2C MYH7 NCOA1 SRF TBP TRIM3 UBTD1 VGLL1 VGLL2 VGLL3 VGLL4 YAP1 ZDHHC17
Entrez ID		4207	7003
HPRD ID		02808	01802
Ensembl ID		ENSG00000213999	ENSG00000187079
Uniprot IDs		Q02080	P28347 Q59EF3
PDB IDs		1N6J 1TQE 6BYY 6BZ1 6C9L 6WC2 6WC5	2HZD 3KYS 4RE1 4Z8E 5NNX 6HIL 6IM5 7CMM 7ZJP 8Q68 9FZA 9GAX
GO Terms Enriched among Interactors		TRNA Threonylcarbamoyladenosine Metabolic Process	Protein Dimerization Activity DNA-binding Transcription Factor Binding Regulation Of DNA-templated Transcription Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of RNA Biosynthetic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Metabolic Process Regulation Of RNA Metabolic Process RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Macromolecule Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Biosynthetic Process Heart Development Positive Regulation Of Metabolic Process Histone Deacetylase Binding Regulation Of Cardiac Muscle Cell Proliferation Regulation Of Developmental Growth Carbon Catabolite Regulation Of Transcription Positive Regulation Of Developmental Growth Regulation Of Growth RNA Polymerase II-specific DNA-binding Transcription Factor Binding Regulation Of Heart Growth Embryonic Heart Tube Morphogenesis RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Regulation Of Gene Expression Female Germ Cell Nucleus Animal Organ Development Regulation Of Macromolecule Biosynthetic Process Anatomical Structure Morphogenesis Chromatin Cardiac Myofibril Assembly Regulation Of Primary Metabolic Process Transcription Regulator Complex Regulation Of Muscle System Process Regulation Of Organ Growth Positive Regulation Of Growth Trophectodermal Cell Differentiation Canonical Glycolysis Glycolytic Process Through Glucose-6-phosphate Glycolytic Process Through Fructose-6-phosphate Epithelial Tube Morphogenesis Transcription Coactivator Activity Platelet Formation Muscle Organ Development Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process