MDH2 and PC

Number of citations of the paper that reports this interaction (PubMedID 8349677)
0

Data Source:
HPRD (in vitro)

		MDH2	PC
Description		malate dehydrogenase 2	pyruvate carboxylase
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GO Annotations	Cellular Component	Nucleus Cytoplasm Mitochondrion Mitochondrial Matrix Membrane Extracellular Exosome	Cytoplasm Mitochondrion Mitochondrial Matrix Cytosol
	Molecular Function	RNA Binding Catalytic Activity Oxidoreductase Activity Malate Dehydrogenase Activity Oxidoreductase Activity, Acting On The CH-OH Group Of Donors, NAD Or NADP As Acceptor L-malate Dehydrogenase (NAD+) Activity Identical Protein Binding L-malate Dehydrogenase (NADP+) Activity	Nucleotide Binding Catalytic Activity Pyruvate Carboxylase Activity Protein Binding ATP Binding Biotin Binding Ligase Activity Identical Protein Binding Metal Ion Binding
	Biological Process	Gluconeogenesis Tricarboxylic Acid Cycle Malate Metabolic Process Aerobic Respiration NAD+ Metabolic Process Carboxylic Acid Metabolic Process Malate-aspartate Shuttle	Gluconeogenesis Lipid Metabolic Process NADP+ Metabolic Process Negative Regulation Of Gene Expression Viral RNA Genome Packaging Viral Release From Host Cell NAD+ Metabolic Process Small Molecule Metabolic Process Host-mediated Activation Of Viral Process
Pathways		Citric acid cycle (TCA cycle) Mitochondrial protein degradation Malate-aspartate shuttle	Biotin transport and metabolism Defective HLCS causes multiple carboxylase deficiency Gluconeogenesis Pyruvate metabolism
Drugs		NADH Citric acid Xanthinol	Pyruvic acid Biotin 5-(hexahydro-2-oxo-1H-thieno[3,4-D]imidazol-6-yl)pentanal
Diseases			Pyruvate carboxylase deficiency
GWAS		Coffee consumption ( 31959922)	A body shape index ( 34021172) Bipolar disorder ( 21926972 31043756 34002096) Familial squamous cell lung carcinoma ( 29924316) Hip circumference adjusted for BMI ( 34021172) HIV-1 susceptibility ( 22174851) Urate levels ( 31578528) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172)
Interacting Genes		11 interacting genes: CRYAB CS FH GOT2 HSPB1 LINC00632 NDUFS1 PC PSMA1 SHANK3 WARS1	7 interacting genes: FNDC3B GOT1 GOT2 LCOR MDH2 RNF10 USP7
Entrez ID		4191	5091
HPRD ID		01099	02032
Ensembl ID		ENSG00000146701	ENSG00000173599
Uniprot IDs		A0A024R4K3 B3KTM1 G3XAL0 P40926	P11498
PDB IDs		2DFD 4WLE 4WLF 4WLN 4WLO 4WLU 4WLV	3BG3 3BG9 7WTA 7WTB 7WTC 7WTD 7WTE 8HWL 8J7O 8XL9
Enriched GO Terms of Interacting Partners?		Mitochondrial Matrix Contractile Muscle Fiber Extracellular Exosome Protein Refolding Tricarboxylic Acid Cycle Mitochondrion NAD+ Metabolic Process Citrate Synthase Activity Fumarate Metabolic Process Fumarate Hydratase Activity Amino Acid Metabolic Process Negative Regulation Of Protein Kinase C Signaling Pyruvate Carboxylase Activity Small Molecule Metabolic Process Acyltransferase Activity, Acyl Groups Converted Into Alkyl On Transfer Catalytic Activity L-glutamate Catabolic Process To Aspartate L-aspartate:2-oxoglutarate Aminotransferase Activity Aspartate Biosynthetic Process Purine Nucleotide Metabolic Process Proteasome Complex Viral RNA Genome Packaging Tryptophan-tRNA Ligase Activity Tryptophanyl-tRNA Aminoacylation Guanylate Kinase-associated Protein Clustering Response To Heat Dicarboxylic Acid Metabolic Process L-aspartate Catabolic Process Nucleotide Metabolic Process Protein Kinase C Inhibitor Activity Positive Regulation Of Synapse Structural Plasticity Striatal Medium Spiny Neuron Differentiation Unfolded Protein Binding Z Disc Citrate Metabolic Process Regulation Of Arginine Metabolic Process Nicotinamide Nucleotide Metabolic Process Trans-4-hydroxy-L-proline Catabolic Process Kynurenine-oxoglutarate Transaminase Activity Purine-containing Compound Metabolic Process Regulation Of Protein Kinase C Signaling Ligase Activity Biotin Binding Negative Regulation Of Cell Volume AMPA Glutamate Receptor Clustering Synaptic Receptor Adaptor Activity NMDA Glutamate Receptor Clustering	Malate-aspartate Shuttle L-glutamate Catabolic Process To Aspartate L-aspartate:2-oxoglutarate Aminotransferase Activity Aspartate Biosynthetic Process L-aspartate Catabolic Process NAD+ Metabolic Process Aspartate Metabolic Process Oxaloacetate Metabolic Process L-glutamate Catabolic Process Dicarboxylic Acid Metabolic Process Nicotinamide Nucleotide Metabolic Process 2-oxoglutarate Metabolic Process Dicarboxylic Acid Catabolic Process Transaminase Activity Glutamate Metabolic Process Aspartate Family Amino Acid Metabolic Process Pyridoxal Phosphate Binding Gluconeogenesis Hexose Biosynthetic Process Glutamine Family Amino Acid Metabolic Process L-glutamate Biosynthetic Process L-malate Dehydrogenase (NADP+) Activity Upper Tip-link Density Myosin VII Complex Amino Acid Biosynthetic Process Catalytic Activity RNA Binding Purine Nucleotide Metabolic Process Proteinogenic Amino Acid Catabolic Process L-amino Acid Catabolic Process L-cysteine Transaminase Activity Phosphatidylserine Decarboxylase Activity Nucleotide Metabolic Process Amino Acid Catabolic Process Response To Transition Metal Nanoparticle L-malate Dehydrogenase (NAD+) Activity Malate Dehydrogenase Activity Symbiont-mediated Disruption Of Host Cell PML Body Small Molecule Biosynthetic Process Carbohydrate Biosynthetic Process Glucose Metabolic Process Purine-containing Compound Metabolic Process Trans-4-hydroxy-L-proline Catabolic Process Kynurenine-oxoglutarate Transaminase Activity Phagolysosome Assembly Stereocilium Base Chondrocyte Development Involved In Endochondral Bone Morphogenesis Glycerol Biosynthetic Process Equilibrioception Postsynapse To Nucleus Signaling Pathway
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