MDH2 and CS

Number of citations: 0 (PubMedID 7285903)
Data Source: HPRD (in vitro)

		MDH2	CS
Name		malate dehydrogenase 2	citrate synthase
Structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Mitochondrion Mitochondrial Matrix Membrane Extracellular Exosome	Nucleus Mitochondrion Mitochondrial Matrix Extracellular Exosome
	Molecular Function	RNA Binding Catalytic Activity Oxidoreductase Activity Malate Dehydrogenase Activity Oxidoreductase Activity, Acting On The CH-OH Group Of Donors, NAD Or NADP As Acceptor L-malate Dehydrogenase (NAD+) Activity Identical Protein Binding L-malate Dehydrogenase (NADP+) Activity	RNA Binding Transferase Activity Citrate Synthase Activity Identical Protein Binding Acyltransferase Activity, Acyl Groups Converted Into Alkyl On Transfer
	Biological Process	Gluconeogenesis Tricarboxylic Acid Cycle Malate Metabolic Process Aerobic Respiration NAD+ Metabolic Process Carboxylic Acid Metabolic Process Malate-aspartate Shuttle	Carbohydrate Metabolic Process Tricarboxylic Acid Cycle Citrate Metabolic Process
Pathways		Citric acid cycle (TCA cycle) Mitochondrial protein degradation Malate-aspartate shuttle	Mitochondrial protein import Citric acid cycle (TCA cycle) Mitochondrial protein degradation Maturation of TCA enzymes and regulation of TCA cycle
Drugs		NADH Citric acid Xanthinol	Trifluoroacetonyl coenzyme A Coenzyme A Oxaloacetate Ion alpha-Fluoro-carboxymethyldethia coenzyme A complex D-Malic acid Nitromethyldethia coenzyme A Citric acid
GWAS		Coffee consumption ( 31959922 )	Height ( 23456168 31562340 34270706 ) Inflammatory skin disease ( 25574825 ) Refractive error ( 32231278 )
Novel Interactors		None recorded	1 novel interactors: AGPS
Interacting Genes		11 interacting genes: CRYAB CS FH GOT2 HSPB1 LINC00632 NDUFS1 PC PSMA1 SHANK3 WARS1	8 interacting genes: CRYAA CRYAB DYNLL1 HSD17B10 HSPB1 LCOR LINC01554 MDH2
Entrez ID		4191	1431
HPRD ID		01099	00349
Ensembl ID		ENSG00000146701	ENSG00000062485
Uniprot IDs		A0A024R4K3 B3KTM1 G3XAL0 P40926	O75390
PDB IDs		2DFD 4WLE 4WLF 4WLN 4WLO 4WLU 4WLV	5UZP 5UZQ 5UZR
GO Terms Enriched among Interactors		Mitochondrial Matrix Contractile Muscle Fiber Extracellular Exosome Protein Refolding Tricarboxylic Acid Cycle Mitochondrion NAD+ Metabolic Process Citrate Synthase Activity Fumarate Metabolic Process Fumarate Hydratase Activity Amino Acid Metabolic Process Negative Regulation Of Protein Kinase C Signaling Pyruvate Carboxylase Activity Small Molecule Metabolic Process Acyltransferase Activity, Acyl Groups Converted Into Alkyl On Transfer Catalytic Activity L-glutamate Catabolic Process To Aspartate L-aspartate:2-oxoglutarate Aminotransferase Activity Aspartate Biosynthetic Process Purine Nucleotide Metabolic Process Proteasome Complex Viral RNA Genome Packaging Tryptophan-tRNA Ligase Activity Tryptophanyl-tRNA Aminoacylation Guanylate Kinase-associated Protein Clustering Response To Heat Dicarboxylic Acid Metabolic Process L-aspartate Catabolic Process Nucleotide Metabolic Process Protein Kinase C Inhibitor Activity Positive Regulation Of Synapse Structural Plasticity Striatal Medium Spiny Neuron Differentiation Unfolded Protein Binding Z Disc Citrate Metabolic Process Regulation Of Arginine Metabolic Process Nicotinamide Nucleotide Metabolic Process Trans-4-hydroxy-L-proline Catabolic Process Kynurenine-oxoglutarate Transaminase Activity Purine-containing Compound Metabolic Process Regulation Of Protein Kinase C Signaling Ligase Activity Biotin Binding Negative Regulation Of Cell Volume AMPA Glutamate Receptor Clustering Synaptic Receptor Adaptor Activity NMDA Glutamate Receptor Clustering	Protein Refolding Tubulin Complex Assembly Response To Heat Unfolded Protein Binding Contractile Muscle Fiber Structural Constituent Of Eye Lens Apoptotic Process Involved In Morphogenesis Response To Temperature Stimulus Apoptotic Process Involved In Development Protein Folding Lens Development In Camera-type Eye Regulation Of Intracellular Transport Negative Regulation Of Intracellular Transport Microtubule-based Process Isoursodeoxycholate 7-beta-dehydrogenase (NAD+) Activity Chenodeoxycholate 7-alpha-dehydrogenase (NAD+) Activity 3-hydroxy-2-methylbutyryl-CoA Dehydrogenase Activity Cholate 7-alpha-dehydrogenase (NAD+) Activity Ursodeoxycholate 7-beta-dehydrogenase (NAD+) Activity Negative Regulation Of Protein Kinase C Signaling Axon Cytoplasm L-malate Dehydrogenase (NADP+) Activity Alkylglycerone-phosphate Synthase Activity Mitochondrion Camera-type Eye Development Identical Protein Binding 17-beta-hydroxysteroid Dehydrogenase (NAD+) Activity Brexanolone Metabolic Process Negative Regulation Of DNA Strand Resection Involved In Replication Fork Processing Response To Hydrogen Peroxide Response To Estradiol Mitochondrial Ribonuclease P Complex Mitochondrial TRNA 5'-end Processing Mitochondrial TRNA 3'-end Processing Mitochondrial TRNA Methylation Protein Kinase C Inhibitor Activity L-malate Dehydrogenase (NAD+) Activity Malate Dehydrogenase Activity Deoxyribonuclease Inhibitor Activity Regulation Of DNA Strand Resection Involved In Replication Fork Processing Nitric-oxide Synthase Inhibitor Activity Eye Development Regulation Of Cellular Localization Z Disc Mitochondrial RNA 5'-end Processing Isoleucine Metabolic Process L-isoleucine Catabolic Process Regulation Of Protein Kinase C Signaling Response To Reactive Oxygen Species TRNA Methyltransferase Complex