MDH2 and WARS

Number of citations of the paper that reports this interaction (PMID 16169070)
531

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		MDH2	WARS
Gene Name		malate dehydrogenase 2, NAD (mitochondrial)	tryptophanyl-tRNA synthetase
Image
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Mitochondrion Mitochondrial Inner Membrane Mitochondrial Matrix Plasma Membrane Extracellular Vesicular Exosome	Nucleus Cytoplasm Cytosol Extracellular Vesicular Exosome
	Molecular Function	L-malate Dehydrogenase Activity Protein Self-association Poly(A) RNA Binding Malate Dehydrogenase (NADP+) Activity	Tryptophan-tRNA Ligase Activity Protein Binding ATP Binding
	Biological Process	Carbohydrate Metabolic Process Glucose Metabolic Process Gluconeogenesis Tricarboxylic Acid Cycle Oxaloacetate Metabolic Process Malate Metabolic Process Internal Protein Amino Acid Acetylation NADH Metabolic Process Pathogenesis Cellular Metabolic Process Cellular Carbohydrate Metabolic Process Small Molecule Metabolic Process	Angiogenesis Translation TRNA Aminoacylation For Protein Translation Tryptophanyl-tRNA Aminoacylation Negative Regulation Of Cell Proliferation Gene Expression Regulation Of Angiogenesis
Pathways		Gluconeogenesis Glucose metabolism Myoclonic epilepsy of Lafora Glycogen storage diseases Pyruvate metabolism and Citric Acid (TCA) cycle The citric acid (TCA) cycle and respiratory electron transport Metabolism of carbohydrates Citric acid cycle (TCA cycle)	Cytosolic tRNA aminoacylation tRNA Aminoacylation
Drugs		NADH Citric Acid	L-Tryptophan Tryptophanyl-5\'amp L-Tryptophanamide
Diseases
GWAS
Protein-Protein Interactions		7 interactors: CRYAB CS FH GOT2 NDUFS1 PC WARS	8 interactors: APP CDK2AP2 DCAF13 DNMT3B EEF1A1 LIG4 MDH2 TERF1
Entrez ID		4191	7453
HPRD ID		01099	01845
Ensembl ID		ENSG00000146701	ENSG00000140105
Uniprot IDs		B3KTM1 B4DE44 E9PDB2 G3XAL0 P40926	P23381
PDB IDs		2DFD	1O5T 1R6T 1R6U 1ULH 2AKE 2AZX 2DR2 2QUH 2QUI 2QUJ 2QUK
Enriched GO Terms of Interacting Partners?		Fumarate Metabolic Process Dicarboxylic Acid Metabolic Process Carboxylic Acid Metabolic Process Organic Acid Metabolic Process Small Molecule Metabolic Process Oxaloacetate Metabolic Process Cellular Respiration Tricarboxylic Acid Cycle Energy Derivation By Oxidation Of Organic Compounds Citrate Metabolic Process Tricarboxylic Acid Metabolic Process Gluconeogenesis Aerobic Respiration Hexose Biosynthetic Process Generation Of Precursor Metabolites And Energy Glutamate Catabolic Process To 2-oxoglutarate Glutamate Catabolic Process To Aspartate Aspartate Biosynthetic Process Tryptophanyl-tRNA Aminoacylation Glucose Metabolic Process Carbohydrate Biosynthetic Process Aspartate Catabolic Process 4-hydroxyproline Catabolic Process L-kynurenine Metabolic Process Pathogenesis Hexose Metabolic Process Glutamate Catabolic Process Aspartate Metabolic Process Tubulin Complex Assembly Monosaccharide Metabolic Process Carbohydrate Metabolic Process Cellular Metabolic Process Biotin Metabolic Process Kynurenine Metabolic Process Dicarboxylic Acid Catabolic Process 2-oxoglutarate Metabolic Process Apoptotic Process Involved In Morphogenesis Cellular Response To Gamma Radiation 4-hydroxyproline Metabolic Process Cellular Modified Amino Acid Catabolic Process Apoptotic Process Involved In Development Cellular Amino Acid Metabolic Process Glutamate Metabolic Process Oxidation-reduction Process Regulation Of Mitochondrial Membrane Potential Developmental Programmed Cell Death Microtubule Polymerization Or Depolymerization Monocarboxylic Acid Metabolic Process Homeostasis Of Number Of Cells Within A Tissue Negative Regulation Of Reactive Oxygen Species Metabolic Process	Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Nitrogen Compound Metabolic Process Neuron Apoptotic Process Neuron Death Response To Radiation Negative Regulation Of Chromosome Organization DNA Ligation Involved In DNA Recombination Positive Regulation Of Mitotic Cell Cycle Synaptic Growth At Neuromuscular Junction Negative Regulation Of Telomere Maintenance Via Semi-conservative Replication Response To Ionizing Radiation Regulation Of Neurogenesis Collateral Sprouting In Absence Of Injury Telomeric Loop Formation Age-dependent Telomere Shortening S-adenosylmethioninamine Metabolic Process Telomere Maintenance Via Telomere Shortening DNA Methylation On Cytosine Within A CG Sequence Negative Regulation Of Cellular Protein Metabolic Process Collateral Sprouting Axon Midline Choice Point Recognition Regulation Of Cell Development Regulation Of Chromosome Organization Negative Regulation Of Protein Metabolic Process Smooth Endoplasmic Reticulum Calcium Ion Homeostasis C-5 Methylation Of Cytosine Lagging Strand Elongation Pro-B Cell Differentiation Negative Regulation Of Telomere Maintenance Via Telomerase S-adenosylhomocysteine Metabolic Process Regulation Of Mitotic Cell Cycle Phase Transition Positive Regulation Of Cell Cycle Process Axon Choice Point Recognition Regulation Of Cell Cycle Phase Transition Methylation-dependent Chromatin Silencing Establishment Of Integrated Proviral Latency Chromosome Organization Neuron Remodeling Immunoglobulin V(D)J Recombination Replicative Cell Aging Establishment Of Viral Latency Cellular Metabolic Process DNA Metabolic Process DNA Replication Positive Regulation Of Cell Cycle Response To Abiotic Stimulus T Cell Receptor V(D)J Recombination
Tagcloud ?		aggravating anxa1 banks bedside confidently cons fth1 ftl gliosis got2 immunochemical infarct infarcted infarcts itraq lagging leak malate mortem plex pros proteome proteomics putamen shuttle slc25a11 slc25a12 tca vim	aspect attenuation axonal bd binswanger cognition computerized concerned conduction cz dementia deterioration disrupted disturbing handedness hbo hyperbaric latency measurement neurophysiological neuropsychological oxygenation rc reflects scanned subcortical tendency wais wmla
Tagcloud (Difference) ?		aggravating anxa1 banks bedside confidently cons fth1 ftl gliosis got2 immunochemical infarct infarcted infarcts itraq lagging leak malate mortem plex pros proteome proteomics putamen shuttle slc25a11 slc25a12 tca vim	aspect attenuation axonal bd binswanger cognition computerized concerned conduction cz dementia deterioration disrupted disturbing handedness hbo hyperbaric latency measurement neurophysiological neuropsychological oxygenation rc reflects scanned subcortical tendency wais wmla
Tagcloud (Intersection) ?