MDH2

Name	malate dehydrogenase 2
Structure
Interactors	11 interactors: CRYAB CS FH GOT2 HSPB1 LINC00632 NDUFS1 PC PSMA1 SHANK3 WARS1
GO Annotations	Cellular Component	Nucleus Cytoplasm Mitochondrion Mitochondrial Matrix Membrane Extracellular Exosome
	Molecular Function	RNA Binding Catalytic Activity Oxidoreductase Activity Malate Dehydrogenase Activity Oxidoreductase Activity, Acting On The CH-OH Group Of Donors, NAD Or NADP As Acceptor L-malate Dehydrogenase (NAD+) Activity Identical Protein Binding L-malate Dehydrogenase (NADP+) Activity
	Biological Process	Gluconeogenesis Tricarboxylic Acid Cycle Malate Metabolic Process Aerobic Respiration NAD+ Metabolic Process Carboxylic Acid Metabolic Process Malate-aspartate Shuttle
Pathways	Citric acid cycle (TCA cycle) Mitochondrial protein degradation Malate-aspartate shuttle
Drugs	NADH Citric acid Xanthinol
GWAS	Coffee consumption ( 31959922 )
Entrez ID	4191
HPRD ID	01099
Ensembl ID	ENSG00000146701
Uniprot IDs	A0A024R4K3 B3KTM1 G3XAL0 P40926
PDB IDs	2DFD 4WLE 4WLF 4WLN 4WLO 4WLU 4WLV
GO Terms Enriched among Interactors ?	Mitochondrial Matrix Contractile Muscle Fiber Extracellular Exosome Protein Refolding Tricarboxylic Acid Cycle Mitochondrion NAD+ Metabolic Process Citrate Synthase Activity Fumarate Metabolic Process Fumarate Hydratase Activity Amino Acid Metabolic Process Negative Regulation Of Protein Kinase C Signaling Pyruvate Carboxylase Activity Small Molecule Metabolic Process Acyltransferase Activity, Acyl Groups Converted Into Alkyl On Transfer Catalytic Activity L-glutamate Catabolic Process To Aspartate L-aspartate:2-oxoglutarate Aminotransferase Activity Aspartate Biosynthetic Process Purine Nucleotide Metabolic Process Proteasome Complex Viral RNA Genome Packaging Tryptophan-tRNA Ligase Activity Tryptophanyl-tRNA Aminoacylation Guanylate Kinase-associated Protein Clustering Response To Heat Dicarboxylic Acid Metabolic Process L-aspartate Catabolic Process Nucleotide Metabolic Process Protein Kinase C Inhibitor Activity Positive Regulation Of Synapse Structural Plasticity Striatal Medium Spiny Neuron Differentiation Unfolded Protein Binding Z Disc Citrate Metabolic Process Regulation Of Arginine Metabolic Process Nicotinamide Nucleotide Metabolic Process Trans-4-hydroxy-L-proline Catabolic Process Kynurenine-oxoglutarate Transaminase Activity Purine-containing Compound Metabolic Process Regulation Of Protein Kinase C Signaling Ligase Activity Biotin Binding Negative Regulation Of Cell Volume AMPA Glutamate Receptor Clustering Synaptic Receptor Adaptor Activity NMDA Glutamate Receptor Clustering