DDI1 and SDS

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		DDI1	SDS
Description		DDI proteasomal shuttling factor 1	serine dehydratase
Image
GO Annotations	Cellular Component		Cytoplasm Mitochondrion Cytosol
	Molecular Function	Aspartic-type Endopeptidase Activity Protein Binding Peptidase Activity Hydrolase Activity	L-serine Ammonia-lyase Activity Threonine Deaminase Activity Protein Binding Lyase Activity Pyridoxal Phosphate Binding Protein Homodimerization Activity
	Biological Process	Proteolysis Proteasomal Protein Catabolic Process Regulation Of Protein Stability Cellular Response To Hydroxyurea Regulation Of DNA Stability	Gluconeogenesis Amino Acid Metabolic Process L-serine Catabolic Process Lipid Metabolic Process Pyruvate Biosynthetic Process Small Molecule Biosynthetic Process
Pathways			Threonine catabolism Serine metabolism
Drugs			Pyridoxal phosphate Serine
Diseases
GWAS		Metabolite levels ( 23823483)	Body mass index ( 26426971) Low high density lipoprotein cholesterol levels ( 26879886)
Interacting Genes		18 interacting genes: ADRM1 CCL28 CYGB DVL2 FAM161B GPANK1 GSK3A KLHL42 MFHAS1 NCCRP1 RALGAPA2 RPP25 SDS TEKT3 TRAF2 UBC UBE2K USP2	3 interacting genes: DDI1 HGS TGM7
Entrez ID		414301	10993
HPRD ID		13128	01633
Ensembl ID		ENSG00000170967	ENSG00000135094
Uniprot IDs		Q8WTU0	P20132 Q8WW81
PDB IDs		3S8I	1P5J 4H27
Enriched GO Terms of Interacting Partners?		Modification-dependent Protein Catabolic Process Ubiquitin Protein Ligase Binding Proteolysis Involved In Protein Catabolic Process Macromolecule Catabolic Process Catabolic Process Proteolysis Positive Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Ubiquitin-dependent Protein Catabolic Process Protein Catabolic Process Regulation Of JNK Cascade Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of UDP-glucose Catabolic Process TORC2 Complex Disassembly Regulation Of Brood Size Outer Acrosomal Membrane Fatty Acid Peroxidase Activity Nitric Oxide Dioxygenase Activity, Heme Protein As Donor
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