SDS and DDI1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		SDS	DDI1
Description		serine dehydratase	DDI proteasomal shuttling factor 1
Image
GO Annotations	Cellular Component	Cytoplasm Mitochondrion Cytosol
	Molecular Function	L-serine Ammonia-lyase Activity Threonine Deaminase Activity Protein Binding Lyase Activity Pyridoxal Phosphate Binding Protein Homodimerization Activity	Aspartic-type Endopeptidase Activity Protein Binding Peptidase Activity Hydrolase Activity
	Biological Process	Gluconeogenesis Amino Acid Metabolic Process L-serine Catabolic Process Lipid Metabolic Process Pyruvate Biosynthetic Process Small Molecule Biosynthetic Process	Proteolysis Proteasomal Protein Catabolic Process Regulation Of Protein Stability Cellular Response To Hydroxyurea Regulation Of DNA Stability
Pathways		Threonine catabolism Serine metabolism
Drugs		Pyridoxal phosphate Serine
Diseases
GWAS		Body mass index ( 26426971) Low high density lipoprotein cholesterol levels ( 26879886)	Metabolite levels ( 23823483)
Interacting Genes		3 interacting genes: DDI1 HGS TGM7	18 interacting genes: ADRM1 CCL28 CYGB DVL2 FAM161B GPANK1 GSK3A KLHL42 MFHAS1 NCCRP1 RALGAPA2 RPP25 SDS TEKT3 TRAF2 UBC UBE2K USP2
Entrez ID		10993	414301
HPRD ID		01633	13128
Ensembl ID		ENSG00000135094	ENSG00000170967
Uniprot IDs		P20132 Q8WW81	Q8WTU0
PDB IDs		1P5J 4H27	3S8I
Enriched GO Terms of Interacting Partners?			Modification-dependent Protein Catabolic Process Ubiquitin Protein Ligase Binding Proteolysis Involved In Protein Catabolic Process Macromolecule Catabolic Process Catabolic Process Proteolysis Positive Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Ubiquitin-dependent Protein Catabolic Process Protein Catabolic Process Regulation Of JNK Cascade Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of UDP-glucose Catabolic Process TORC2 Complex Disassembly Regulation Of Brood Size Outer Acrosomal Membrane Fatty Acid Peroxidase Activity Nitric Oxide Dioxygenase Activity, Heme Protein As Donor
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