DDI1 and CCL28

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid, two hybrid)

		DDI1	CCL28
Description		DDI proteasomal shuttling factor 1	C-C motif chemokine ligand 28
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GO Annotations	Cellular Component		Extracellular Region Extracellular Space Secretory Granule Extracellular Exosome
	Molecular Function	Aspartic-type Endopeptidase Activity Protein Binding Peptidase Activity Hydrolase Activity	Cytokine Activity Protein Binding Chemokine Activity Chemokine Receptor Binding CXCR Chemokine Receptor Binding
	Biological Process	Proteolysis Proteasomal Protein Catabolic Process Regulation Of Protein Stability Cellular Response To Hydroxyurea Regulation Of DNA Stability	Positive Regulation Of Cell-matrix Adhesion Chemotaxis Inflammatory Response Immune Response Signal Transduction Positive Regulation Of Cytosolic Calcium Ion Concentration Response To Nutrient Neutrophil Chemotaxis Killing Of Cells Of Another Organism Cytolysis In Another Organism Cell Chemotaxis Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Cellular Response To Lipopolysaccharide Negative Regulation Of Leukocyte Tethering Or Rolling
Pathways			Chemokine receptors bind chemokines G alpha (i) signalling events
Drugs
Diseases
GWAS		Metabolite levels ( 23823483)	Metabolite levels (X-11787) ( 23934736) Post bronchodilator FEV1/FVC ratio in COPD ( 26634245)
Interacting Genes		18 interacting genes: ADRM1 CCL28 CYGB DVL2 FAM161B GPANK1 GSK3A KLHL42 MFHAS1 NCCRP1 RALGAPA2 RPP25 SDS TEKT3 TRAF2 UBC UBE2K USP2	26 interacting genes: ACKR2 CCL11 CCL13 CCL17 CCL21 CCL26 CCL5 CCR10 CCR3 CXCL10 CXCL12 CXCL13 CXCL14 CXCL17 CXCL2 CXCL9 DDI1 DYNLT3 PF4 PF4V1 PPBP PSMA3 STUB1 TSC1 XCL1 XCL2
Entrez ID		414301	56477
HPRD ID		13128	05577
Ensembl ID		ENSG00000170967	ENSG00000151882
Uniprot IDs		Q8WTU0	A0N0Q3 D6RC73 Q9NRJ3
PDB IDs		3S8I	6CWS
Enriched GO Terms of Interacting Partners?		Modification-dependent Protein Catabolic Process Ubiquitin Protein Ligase Binding Proteolysis Involved In Protein Catabolic Process Macromolecule Catabolic Process Catabolic Process Proteolysis Positive Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Ubiquitin-dependent Protein Catabolic Process Protein Catabolic Process Regulation Of JNK Cascade Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of UDP-glucose Catabolic Process TORC2 Complex Disassembly Regulation Of Brood Size Outer Acrosomal Membrane Fatty Acid Peroxidase Activity Nitric Oxide Dioxygenase Activity, Heme Protein As Donor	Chemokine Activity Cell Chemotaxis Chemotaxis Locomotion Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Antimicrobial Humoral Response Chemokine-mediated Signaling Pathway Cytokine Activity Humoral Immune Response Leukocyte Chemotaxis Cell Migration Granulocyte Chemotaxis Killing Of Cells Of Another Organism Cell Motility Myeloid Leukocyte Migration Granulocyte Migration Immune Response Leukocyte Migration Inflammatory Response Cell Killing Cytokine-mediated Signaling Pathway Immune System Process Defense Response To Symbiont CXCR Chemokine Receptor Binding Defense Response To Other Organism Defense Response CCR Chemokine Receptor Binding Response To Other Organism G Protein-coupled Receptor Signaling Pathway Mononuclear Cell Migration Extracellular Space Response To External Biotic Stimulus Neutrophil Chemotaxis Neutrophil Migration Response To Stress Positive Regulation Of T Cell Migration Regulation Of T Cell Chemotaxis Extracellular Region CXCR3 Chemokine Receptor Binding Positive Regulation Of Chemotaxis Positive Regulation Of Lymphocyte Migration Positive Regulation Of Leukocyte Chemotaxis Eosinophil Chemotaxis Positive Regulation Of Mononuclear Cell Migration Regulation Of T Cell Migration Eosinophil Migration Positive Regulation Of Cell Migration Regulation Of Lymphocyte Chemotaxis Lymphocyte Chemotaxis Signal Transduction
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