DDI1 and NCCRP1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		DDI1	NCCRP1
Description		DDI proteasomal shuttling factor 1	NCCRP1, F-box associated domain containing
Image			No pdb structure
GO Annotations	Cellular Component		Cytoplasm Cytosol SCF Ubiquitin Ligase Complex Extracellular Exosome
	Molecular Function	Aspartic-type Endopeptidase Activity Protein Binding Peptidase Activity Hydrolase Activity	Protein Binding Ubiquitin Protein Ligase Activity
	Biological Process	Proteolysis Proteasomal Protein Catabolic Process Regulation Of Protein Stability Cellular Response To Hydroxyurea Regulation Of DNA Stability	Glycoprotein Catabolic Process Positive Regulation Of Cell Population Proliferation SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process ERAD Pathway
Pathways
Drugs
Diseases
GWAS		Metabolite levels ( 23823483)
Interacting Genes		18 interacting genes: ADRM1 CCL28 CYGB DVL2 FAM161B GPANK1 GSK3A KLHL42 MFHAS1 NCCRP1 RALGAPA2 RPP25 SDS TEKT3 TRAF2 UBC UBE2K USP2	3 interacting genes: CFTR DDI1 MCPH1
Entrez ID		414301	342897
HPRD ID		13128	17357
Ensembl ID		ENSG00000170967	ENSG00000188505
Uniprot IDs		Q8WTU0	Q6ZVX7
PDB IDs		3S8I
Enriched GO Terms of Interacting Partners?		Modification-dependent Protein Catabolic Process Ubiquitin Protein Ligase Binding Proteolysis Involved In Protein Catabolic Process Macromolecule Catabolic Process Catabolic Process Proteolysis Positive Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Ubiquitin-dependent Protein Catabolic Process Protein Catabolic Process Regulation Of JNK Cascade Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of UDP-glucose Catabolic Process TORC2 Complex Disassembly Regulation Of Brood Size Outer Acrosomal Membrane Fatty Acid Peroxidase Activity Nitric Oxide Dioxygenase Activity, Heme Protein As Donor	Positive Regulation Of Anion Channel Activity Positive Regulation Of Enamel Mineralization Intracellularly ATP-gated Chloride Channel Activity Positive Regulation Of Voltage-gated Chloride Channel Activity Sec61 Translocon Complex Binding Positive Regulation Of Monoatomic Anion Transport Regulation Of DNA Stability Transepithelial Water Transport Positive Regulation Of Tooth Mineralization Chloride Channel Inhibitor Activity Chloride Channel Regulator Activity Regulation Of Enamel Mineralization Membrane Hyperpolarization Bicarbonate Transmembrane Transporter Activity Intracellular PH Elevation Amelogenesis ATPase-coupled Inorganic Anion Transmembrane Transporter Activity Regulation Of Monoatomic Anion Transport Organelle Localization Epithelial Fluid Transport Cellular Response To Hydroxyurea Response To Hydroxyurea Golgi-associated Vesicle Membrane Regulation Of Chromosome Condensation Cellular Response To Forskolin Response To Forskolin Chloride Transmembrane Transporter Activity Sperm Capacitation Aspartic-type Endopeptidase Activity Neuronal Stem Cell Population Maintenance Bicarbonate Transport Water Transport Protein Localization To Centrosome Multicellular Organismal-level Water Homeostasis Positive Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Positive Regulation Of Ion Transmembrane Transporter Activity Cholesterol Biosynthetic Process 14-3-3 Protein Binding Fluid Transport Transepithelial Transport Establishment Of Mitotic Spindle Orientation Vesicle Docking Involved In Exocytosis Positive Regulation Of Transporter Activity Sterol Biosynthetic Process ABC-type Transporter Activity Establishment Of Mitotic Spindle Localization Establishment Of Spindle Orientation Chloride Channel Complex Positive Regulation Of Biomineral Tissue Development Protein Localization To Cytoskeleton
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