MAT1A and MAT2A

Number of citations of the paper that reports this interaction (PubMedID 40437099)
172

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, biochemical, biochemical)

		MAT1A	MAT2A
Description		methionine adenosyltransferase 1A	methionine adenosyltransferase 2A
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GO Annotations	Cellular Component	Cytosol Methionine Adenosyltransferase Complex	Cytosol Methionine Adenosyltransferase Complex
	Molecular Function	Nucleotide Binding Methionine Adenosyltransferase Activity Protein Binding ATP Binding Transferase Activity Identical Protein Binding Metal Ion Binding	Nucleotide Binding Methionine Adenosyltransferase Activity Protein Binding ATP Binding Transferase Activity Small Molecule Binding Identical Protein Binding Metal Ion Binding
	Biological Process	S-adenosylmethionine Biosynthetic Process One-carbon Metabolic Process L-methionine Catabolic Process Protein Complex Oligomerization Protein Homotetramerization	S-adenosylmethionine Biosynthetic Process One-carbon Metabolic Process Protein-containing Complex Localization Cellular Response To Nutrient Levels Cellular Response To Amino Acid Starvation Protein Hexamerization TORC1 Signaling Protein Complex Oligomerization Protein Heterooligomerization Cellular Response To Methionine Protein Localization To Lysosome Negative Regulation Of TORC1 Signaling Positive Regulation Of TORC1 Signaling Cellular Response To Leukemia Inhibitory Factor
Pathways		Methylation Sulfur amino acid metabolism Metabolism of ingested SeMet, Sec, MeSec into H2Se Defective MAT1A causes MATD	Methylation
Drugs		Ademetionine 3-Oxiran-2ylalanine L-2-amino-4-methoxy-cis-but-3-enoic acid	Ademetionine
Diseases		Hypermethioninemia; Methionine adenosyltransferase deficiency; S-adenosylhomocysteine hydrolase deficiency
GWAS		Diabetic kidney disease ( 26305897)	Coronary artery disease ( 29212778) Dysmenorrheic pain ( 27454463) Myocardial infarction ( 33532862) Urinary albumin excretion ( 30220432)
Interacting Genes		1 interacting genes: MAT2A	10 interacting genes: CEBPA CUL3 DSCAM HGS MAT1A MAT2B OGT PRC1 TMEM213 UBE2I
Entrez ID		4143	4144
HPRD ID		02013	03275
Ensembl ID		ENSG00000151224	ENSG00000168906
Uniprot IDs		Q00266	A0A140VJP5 P31153
PDB IDs		2OBV 6SW5 6SW6 8SWA	2P02 4KTT 4KTV 4NDN 5A19 5A1G 5A1I 5UGH 6FAJ 6FBN 6FBO 6FBP 6FCB 6FCD 6FWB 6G6R 6P9V 6WKB 7BHR 7BHS 7BHT 7BHU 7BHV 7BHW 7BHX 7KCC 7KCE 7KCF 7KDA 7KDB 7L1A 7LNH 7RW5 7RW7 7RWG 7RWH 7RXV 7RXW 7RXX 8AXZ 8OOG 8P1T 8P1V 8P1W 8P4H 8QDY 8QDZ 8QE0 8QE1 8QE2 8QE3 8XAM 8XAR 8XB0 8XJ2
Enriched GO Terms of Interacting Partners?		Methionine Adenosyltransferase Activity Methionine Adenosyltransferase Complex S-adenosylmethionine Biosynthetic Process Response To Methionine Cellular Response To Methionine S-adenosylmethionine Metabolic Process Protein Hexamerization One-carbon Metabolic Process Small Molecule Binding Protein Heterooligomerization Cellular Response To Nutrient Protein Localization To Lysosome Cellular Response To Leukemia Inhibitory Factor Cellular Response To Amino Acid Starvation Positive Regulation Of TOR Signaling Protein Localization To Vacuole Response To Amino Acid Starvation Negative Regulation Of TORC1 Signaling Sulfur Compound Biosynthetic Process Positive Regulation Of TORC1 Signaling Protein-containing Complex Localization Regulation Of TORC1 Signaling Negative Regulation Of TOR Signaling TOR Signaling Response To Leukemia Inhibitory Factor Cellular Response To Amino Acid Stimulus TORC1 Signaling Response To Amino Acid Regulation Of TOR Signaling Response To Nutrient Cellular Response To Starvation Response To Starvation Protein Complex Oligomerization Cellular Response To Nutrient Levels Sulfur Compound Metabolic Process	Methionine Adenosyltransferase Complex S-adenosylmethionine Biosynthetic Process S-adenosylmethionine Metabolic Process Cellular Component Assembly One-carbon Metabolic Process Chromatin DNA Binding Regulation Of Protein Catabolic Process RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Response To Vitamin B2 C/EBP Complex Post-embryonic Retina Morphogenesis In Camera-type Eye Netrin Receptor Binding L-methionine Catabolic Process Methionine Adenosyltransferase Activity SUMO Conjugating Enzyme Activity Trophectodermal Cellular Morphogenesis Liver Morphogenesis Positive Regulation Of TOR Signaling Positive Regulation Of TORC1 Signaling Regulation Of Cytokinesis Protein Localization To Lysosome Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly Mitotic Spindle Elongation Methionine Adenosyltransferase Regulator Activity Protein Localization To Vacuole CHOP-C/EBP Complex Negative Regulation Of Transcription By RNA Polymerase II Sulfur Compound Biosynthetic Process RING-like Zinc Finger Domain Binding Regulation Protein Catabolic Process At Postsynapse Regulation Of TORC1 Signaling Protein O-acetylglucosaminyltransferase Activity ESCRT-0 Complex Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Response To Phenylpropanoid Response To Nutrient Levels Positive Regulation Of Gene Expression Inflammatory Response Response To Nutrient White Fat Cell Proliferation Negative Regulation Of Multicellular Organismal Process Negative Regulation Of Hematopoietic Stem Cell Proliferation Rb-E2F Complex Positive Regulation Of Axon Extension Involved In Axon Guidance Regulation Of Phosphorus Metabolic Process Catabolic Process SUMO Ligase Complex Small Protein Activating Enzyme Binding Cell Division
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