MAT1A

Description		methionine adenosyltransferase 1A
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GO Annotations	Cellular Component	Cytosol Methionine Adenosyltransferase Complex
	Molecular Function	Nucleotide Binding Methionine Adenosyltransferase Activity Protein Binding ATP Binding Transferase Activity Identical Protein Binding Metal Ion Binding
	Biological Process	S-adenosylmethionine Biosynthetic Process One-carbon Metabolic Process L-methionine Catabolic Process Protein Complex Oligomerization Protein Homotetramerization
Pathways		Methylation Sulfur amino acid metabolism Metabolism of ingested SeMet, Sec, MeSec into H2Se Defective MAT1A causes MATD
Drugs		Ademetionine 3-Oxiran-2ylalanine L-2-amino-4-methoxy-cis-but-3-enoic acid
Diseases		Hypermethioninemia; Methionine adenosyltransferase deficiency; S-adenosylhomocysteine hydrolase deficiency
GWAS		Diabetic kidney disease ( 26305897)
Interacting Genes		1 interacting genes: MAT2A
Entrez ID		4143
HPRD ID		02013
Ensembl ID		ENSG00000151224
Uniprot IDs		Q00266
PDB IDs		2OBV 6SW5 6SW6 8SWA
Enriched GO Terms of Interacting Partners?		Methionine Adenosyltransferase Activity Methionine Adenosyltransferase Complex S-adenosylmethionine Biosynthetic Process Response To Methionine Cellular Response To Methionine S-adenosylmethionine Metabolic Process Protein Hexamerization One-carbon Metabolic Process Small Molecule Binding Protein Heterooligomerization Cellular Response To Nutrient Protein Localization To Lysosome Cellular Response To Leukemia Inhibitory Factor Cellular Response To Amino Acid Starvation Positive Regulation Of TOR Signaling Protein Localization To Vacuole Response To Amino Acid Starvation Negative Regulation Of TORC1 Signaling Sulfur Compound Biosynthetic Process Positive Regulation Of TORC1 Signaling Protein-containing Complex Localization Regulation Of TORC1 Signaling Negative Regulation Of TOR Signaling TOR Signaling Response To Leukemia Inhibitory Factor Cellular Response To Amino Acid Stimulus TORC1 Signaling Response To Amino Acid Regulation Of TOR Signaling Response To Nutrient Cellular Response To Starvation Response To Starvation Protein Complex Oligomerization Cellular Response To Nutrient Levels Sulfur Compound Metabolic Process
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