MAP2 and MARK4

Number of citations of the paper that reports this interaction (PubMedID 14594945)
0

Data Source:
HPRD (in vitro)

		MAP2	MARK4
Description		microtubule associated protein 2	microtubule affinity regulating kinase 4
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Cytoskeleton Microtubule Microtubule Associated Complex Plasma Membrane Cilium Dendrite Dendrite Cytoplasm Cell Projection Neuron Projection Neuronal Cell Body Axon Initial Segment Dendritic Shaft Axon Hillock Dendritic Growth Cone Main Axon Dendritic Branch Basal Dendrite Primary Dendrite Distal Dendrite Apical Distal Dendrite Dendritic Filopodium Proximal Dendrite Proximal Neuron Projection	Gamma-tubulin Complex Cytoplasm Centrosome Microtubule Organizing Center Cytosol Cytoskeleton Microtubule Cytoskeleton Dendrite Midbody Ciliary Basal Body Cell Projection Neuron Projection
	Molecular Function	Dystroglycan Binding Structural Molecule Activity Protein Binding Calmodulin Binding Microtubule Binding Tubulin Binding Tau Protein Binding	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Microtubule Binding Cytoskeletal Anchor Activity Kinase Activity Transferase Activity Gamma-tubulin Binding Ubiquitin Binding Tau Protein Binding Tau-protein Kinase Activity Protein Serine Kinase Activity
	Biological Process	Microtubule Cytoskeleton Organization Dendrite Development Central Nervous System Neuron Development Negative Regulation Of Axon Extension Regulation Of Microtubule Polymerization Negative Regulation Of Microtubule Polymerization Neuron Projection Development Regulation Of Protein Localization Dendrite Morphogenesis Positive Regulation Of Anterograde Dense Core Granule Transport Regulation Of Organelle Transport Along Microtubule Positive Regulation Of Anterograde Synaptic Vesicle Transport	Microtubule Cytoskeleton Organization Microtubule Bundle Formation Protein Phosphorylation Nervous System Development Cell Projection Organization Intracellular Signal Transduction Positive Regulation Of Programmed Cell Death Cilium Organization Positive Regulation Of Cilium Assembly Positive Regulation Of Cell Cycle Regulation Of Centrosome Cycle Microtubule Polymerization Cell Division Cilium Disassembly Positive Regulation Of NLRP3 Inflammasome Complex Assembly Positive Regulation Of Protein Localization To Centrosome
Pathways			Anchoring of the basal body to the plasma membrane
Drugs		Estramustine Paclitaxel Docetaxel	Fostamatinib
Diseases
GWAS		Adventurousness ( 30643258) Bipolar disorder ( 31043756) Body mass index ( 28552196) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (MOSTest) ( 32665545) General risk tolerance (MTAG) ( 30643258) Handedness (Left-handed vs. non-left-handed) ( 30980028 31504236) Handedness (left-handed vs. right-handed) ( 31504236) Height ( 28552196) LDL cholesterol levels in HIV infection ( 33109212) Left-handedness ( 32989287) Left–right brain asymmetry ( 33723403) Skin and soft tissue infections ( 33662382) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545)	Adult body size ( 32376654) Advanced age-related macular degeneration ( 26691988) Alzheimer's disease or family history of Alzheimer's disease ( 30617256) Alzheimer's disease or HDL levels (pleiotropy) ( 30805717) Basophil count ( 32888494) Body mass index ( 26426971) Body mass index (age>50) ( 26426971) Body mass index x age interaction ( 26426971) Body mass index x sex x age interaction (4df test) ( 26426971) Eosinophil count ( 32888494 27863252) Eosinophil percentage of white cells ( 32888494) Femur bone mineral density x serum urate levels interaction ( 34046847) Granulocyte count ( 27863252) Hematocrit ( 27863252 32888494) Hemoglobin ( 32888494) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Immature fraction of reticulocytes ( 32888494) L1-L4 bone mineral density x serum urate levels interaction ( 34046847) LDL cholesterol levels ( 32203549) Lymphocyte count ( 32888494) Lymphocyte percentage of white cells ( 32888494) Mean platelet volume ( 32888494) Mean reticulocyte volume ( 32888494) Monocyte count ( 32888494 27863252) Monocyte percentage of white cells ( 27863252 32888494) Myeloid white cell count ( 27863252) Neutrophil count ( 27863252) Neutrophil percentage of white cells ( 32888494) Parental longevity (father's attained age) ( 29227965) Platelet count ( 27863252 32888494) Platelet distribution width ( 27863252 32888494) Plateletcrit ( 32888494 27863252) Red blood cell count ( 32888494) Red cell distribution width ( 32888494) Reticulocyte count ( 32888494) Sum basophil neutrophil counts ( 27863252) Sum eosinophil basophil counts ( 27863252) Sum neutrophil eosinophil counts ( 27863252) Triglyceride levels ( 32203549) White blood cell count ( 27863252 32888494)
Interacting Genes		26 interacting genes: ACTB ACTN1 APOE APP CPEB1 DAG1 FYN GRB2 GRIN1 GRIN2D ITCH JUNB MARK1 MARK3 MARK4 MDM2 MYO7A NEDD4L NEFL PAFAH1B1 PLEC PRKACA PRKAR2A SRC TTBK1 YAP1	32 interacting genes: AKT1 APLNR CDC42 HGS HNRNPK HPS6 KHDRBS3 KRT31 KRT40 MAP2 MAP4 MAPT MED20 MTUS2 NEDD4 NLRP3 NOTCH2NLA ODF2 PARD6A PNMA1 PRKCG PRKCI PRNP PTBP1 RPTOR STK11 TUBA4A TUBB TUBG1 YWHAB YWHAH YWHAZ
Entrez ID		4133	57787
HPRD ID		01140	09402
Ensembl ID		ENSG00000078018	ENSG00000007047
Uniprot IDs		A0A024R3Z1 P11137 Q6NYC5	Q96L34
PDB IDs			5ES1 8XFL
Enriched GO Terms of Interacting Partners?		Tau Protein Binding Intracellular Signal Transduction Cellular Response To Oxygen-containing Compound Tau-protein Kinase Activity Regulation Of Protein Localization Regulation Of Plasma Membrane Bounded Cell Projection Organization Regulation Of Cell Projection Organization Modulation Of Chemical Synaptic Transmission Protein Domain Specific Binding Anatomical Structure Morphogenesis Glutamatergic Synapse Regulation Of Cellular Component Organization Cytoskeleton Organization Regulation Of Synapse Organization Positive Regulation Of Protein Localization Regulation Of Multicellular Organismal Process Dendrite Phospholipase Binding Developmental Process Supramolecular Fiber Organization Regulation Of Developmental Process System Process Ephrin Receptor Binding Negative Regulation Of Intracellular Signal Transduction Positive Regulation Of Developmental Process Response To Hormone Cytoplasm Plasma Membrane Regulation Of Cell Activation Response To Peptide Hormone Regulation Of Endocytosis Positive Regulation Of Cellular Component Organization Nervous System Process Cellular Component Assembly Negative Regulation Of Signal Transduction Extracellular Exosome Cell-cell Junction Regulation Of Cellular Localization Cytosol Protein-containing Complex Binding Negative Regulation Of Signaling Negative Regulation Of Cell Communication Regulation Of Dendritic Spine Maintenance Cellular Response To Amyloid-beta Glutamate Receptor Signaling Pathway Regulation Of Vesicle-mediated Transport Regulation Of Protein Catabolic Process Regulation Of Cell Differentiation Regulation Of System Process Regulation Of Neuronal Synaptic Plasticity	Microtubule Cytoskeleton Protein Domain Specific Binding Regulation Of Plasma Membrane Bounded Cell Projection Organization Regulation Of Cell Projection Organization Phosphoserine Residue Binding Microtubule Regulation Of Cellular Component Organization Cytosol Cytoskeleton Structural Molecule Activity Regulation Of Transport Golgi Localization Organelle Organization Cytoplasm Regulation Of Cellular Localization Tubulin Binding Regulation Of Cell Communication Regulation Of Signaling Cilium Intracellular Protein Localization GTP-dependent Protein Binding Cytoskeleton Organization Extracellular Exosome Regulation Of Neuron Projection Development Positive Regulation Of Transport Regulation Of Synapse Organization Negative Regulation Of Cell Projection Organization Positive Regulation Of Vesicle Transport Along Microtubule Nuclear Receptor-mediated Glucocorticoid Signaling Pathway Supramolecular Fiber Organization Regulation Of Signal Transduction Regulation Of Protein Localization Regulation Of TORC1 Signaling Neuron Projection Main Axon Nuclear Receptor-mediated Corticosteroid Signaling Pathway Structural Constituent Of Cytoskeleton Protein Targeting PAR Polarity Complex Enzyme Binding Regulation Of Cell Growth Microtubule-based Process Establishment Of Golgi Localization Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Microtubule Binding Regulation Of Cell Development Regulation Of Organelle Transport Along Microtubule Transmembrane Transporter Binding Establishment Or Maintenance Of Apical/basal Cell Polarity Regulation Of Nervous System Development
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