MAP2 and ACSL3

Data Source: HiPPIP (Novel)

		MAP2	ACSL3
Name		microtubule associated protein 2	acyl-CoA synthetase long chain family member 3
Structure		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Cytoskeleton Microtubule Microtubule Associated Complex Plasma Membrane Cilium Dendrite Dendrite Cytoplasm Cell Projection Neuron Projection Neuronal Cell Body Axon Initial Segment Dendritic Shaft Axon Hillock Dendritic Growth Cone Main Axon Dendritic Branch Basal Dendrite Primary Dendrite Distal Dendrite Apical Distal Dendrite Dendritic Filopodium Proximal Dendrite Proximal Neuron Projection	Mitochondrion Mitochondrial Outer Membrane Peroxisome Peroxisomal Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Lipid Droplet Plasma Membrane Membrane Perinuclear Region Of Cytoplasm
	Molecular Function	Dystroglycan Binding Structural Molecule Activity Protein Binding Calmodulin Binding Microtubule Binding Tubulin Binding Tau Protein Binding	Nucleotide Binding Long-chain Fatty Acid-CoA Ligase Activity Protein Binding ATP Binding Ligase Activity Protein Kinase Binding Protein Domain Specific Binding Medium-chain Fatty Acid-CoA Ligase Activity Arachidonate-CoA Ligase Activity Palmitoyl-CoA Ligase Activity Fatty Acid-CoA Ligase Activity
	Biological Process	Microtubule Cytoskeleton Organization Dendrite Development Central Nervous System Neuron Development Negative Regulation Of Axon Extension Regulation Of Microtubule Polymerization Negative Regulation Of Microtubule Polymerization Neuron Projection Development Regulation Of Protein Localization Dendrite Morphogenesis Positive Regulation Of Anterograde Dense Core Granule Transport Regulation Of Organelle Transport Along Microtubule Positive Regulation Of Anterograde Synaptic Vesicle Transport	Long-chain Fatty Acid Metabolic Process Lipid Metabolic Process Fatty Acid Metabolic Process Neuron Differentiation Very-low-density Lipoprotein Particle Assembly Long-chain Fatty-acyl-CoA Metabolic Process Long-chain Fatty-acyl-CoA Biosynthetic Process Positive Regulation Of Golgi To Plasma Membrane Protein Transport Long-chain Fatty Acid Import Into Cell Positive Regulation Of Secretion Positive Regulation Of Phosphatidylcholine Biosynthetic Process
Pathways		None	Intracellular metabolism of fatty acids regulates insulin secretion Synthesis of very long-chain fatty acyl-CoAs
Drugs		Estramustine Paclitaxel Docetaxel	None
GWAS		Adventurousness ( 30643258 ) Bipolar disorder ( 31043756 ) Body mass index ( 28552196 ) Brain morphology (min-P) ( 32665545 ) Brain morphology (MOSTest) ( 32665545 ) Cortical surface area (MOSTest) ( 32665545 ) Cortical thickness (MOSTest) ( 32665545 ) General risk tolerance (MTAG) ( 30643258 ) Handedness (Left-handed vs. non-left-handed) ( 30980028 31504236 ) Handedness (left-handed vs. right-handed) ( 31504236 ) Height ( 28552196 ) LDL cholesterol levels in HIV infection ( 33109212 ) Left-handedness ( 32989287 ) Left–right brain asymmetry ( 33723403 ) Skin and soft tissue infections ( 33662382 ) Subcortical volume (min-P) ( 32665545 ) Subcortical volume (MOSTest) ( 32665545 )	Mild influenza (H1N1) infection ( 26379185 )
Novel Interactors		1 novel interactors: ACSL3	6 novel interactors: BARD1 CAPS MAP2 MMP13 SMARCAL1 TAS2R14
Interacting Genes		26 interacting genes: ACTB ACTN1 APOE APP CPEB1 DAG1 FYN GRB2 GRIN1 GRIN2D ITCH JUNB MARK1 MARK3 MARK4 MDM2 MYO7A NEDD4L NEFL PAFAH1B1 PLEC PRKACA PRKAR2A SRC TTBK1 YAP1	3 interacting genes: APP NDRG1 WEE2-AS1
Entrez ID		4133	2181
HPRD ID		01140	03845
Ensembl ID		ENSG00000078018	ENSG00000123983
Uniprot IDs		A0A024R3Z1 P11137 Q6NYC5	O95573
PDB IDs		Not available	Not available
GO Terms Enriched among Interactors		Tau Protein Binding Intracellular Signal Transduction Cellular Response To Oxygen-containing Compound Tau-protein Kinase Activity Regulation Of Protein Localization Regulation Of Plasma Membrane Bounded Cell Projection Organization Regulation Of Cell Projection Organization Modulation Of Chemical Synaptic Transmission Protein Domain Specific Binding Anatomical Structure Morphogenesis Glutamatergic Synapse Regulation Of Cellular Component Organization Cytoskeleton Organization Regulation Of Synapse Organization Positive Regulation Of Protein Localization Regulation Of Multicellular Organismal Process Dendrite Phospholipase Binding Developmental Process Supramolecular Fiber Organization Regulation Of Developmental Process System Process Ephrin Receptor Binding Negative Regulation Of Intracellular Signal Transduction Positive Regulation Of Developmental Process Response To Hormone Cytoplasm Plasma Membrane Regulation Of Cell Activation Response To Peptide Hormone Regulation Of Endocytosis Positive Regulation Of Cellular Component Organization Nervous System Process Cellular Component Assembly Negative Regulation Of Signal Transduction Extracellular Exosome Cell-cell Junction Regulation Of Cellular Localization Cytosol Protein-containing Complex Binding Negative Regulation Of Signaling Negative Regulation Of Cell Communication Regulation Of Dendritic Spine Maintenance Cellular Response To Amyloid-beta Glutamate Receptor Signaling Pathway Regulation Of Vesicle-mediated Transport Regulation Of Protein Catabolic Process Regulation Of Cell Differentiation Regulation Of System Process Regulation Of Neuronal Synaptic Plasticity	Main Axon Acetylcholine Receptor Activator Activity Amyloid-beta Complex Dendritic Shaft Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Response To Amyloid-beta Positive Regulation Of Toll Signaling Pathway Lipoprotein Particle Dendrite Development Positive Regulation Of Protein Import Histone H2AK127 Ubiquitin Ligase Activity Histone H2AK129 Ubiquitin Ligase Activity Negative Regulation Of MRNA 3'-end Processing BRCA1-BARD1 Complex Dendritic Filopodium Positive Regulation Of Anterograde Synaptic Vesicle Transport Distal Dendrite Apical Distal Dendrite Positive Regulation Of Anterograde Dense Core Granule Transport Primary Dendrite PTB Domain Binding Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Endothelin Production Growth Cone Filopodium Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Proximal Neuron Projection Dendritic Branch Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Cellular Response To Norepinephrine Stimulus Myeloid Leukocyte Activation Astrocyte Activation Involved In Immune Response Low-density Lipoprotein Particle Mediated Signaling BRCA1-B Complex Positive Regulation Of Vesicle Transport Along Microtubule Pre-mRNA 5'-splice Site Binding Intermediate-density Lipoprotein Particle Axon Midline Choice Point Recognition Positive Regulation Of Amyloid Fibril Formation Growth Factor Receptor Binding Regulation Of Synaptic Vesicle Transport Basal Dendrite Nickel Cation Binding ATP-dependent DNA/DNA Annealing Activity