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APOA4 and GPLD1
Number of citations of the paper that reports this interaction (PMID
11254757
)
2
Data Source:
HPRD
(in vivo, in vitro)
APOA4
GPLD1
Gene Name
apolipoprotein A-IV
glycosylphosphatidylinositol specific phospholipase D1
Image
No pdb structure
No pdb structure
Gene Ontology Annotations
Cellular Component
Extracellular Region
Extracellular Space
Early Endosome
Endoplasmic Reticulum Lumen
Cytosol
Cell Surface
Very-low-density Lipoprotein Particle
High-density Lipoprotein Particle
Chylomicron
Extracellular Vesicular Exosome
Blood Microparticle
Proteinaceous Extracellular Matrix
Extracellular Space
Intracellular
Cytoplasm
Lysosomal Membrane
Intracellular Membrane-bounded Organelle
Extracellular Vesicular Exosome
Molecular Function
Lipid Transporter Activity
Copper Ion Binding
Protein Binding
Lipid Binding
Cholesterol Binding
Antioxidant Activity
Cholesterol Transporter Activity
Phosphatidylcholine Binding
Protein Homodimerization Activity
Phosphatidylcholine-sterol O-acyltransferase Activator Activity
Glycosylphosphatidylinositol Phospholipase D Activity
Phospholipase D Activity
Sodium Channel Regulator Activity
Biological Process
Retinoid Metabolic Process
Innate Immune Response In Mucosa
Cholesterol Biosynthetic Process
Lipid Transport
Response To Lipid Hydroperoxide
Leukocyte Cell-cell Adhesion
Phototransduction, Visible Light
Cholesterol Metabolic Process
Positive Regulation Of Cholesterol Esterification
Positive Regulation Of Triglyceride Catabolic Process
Removal Of Superoxide Radicals
Regulation Of Intestinal Cholesterol Absorption
Neuron Projection Regeneration
Regulation Of Cholesterol Transport
Cholesterol Efflux
Phospholipid Efflux
Chylomicron Remodeling
Very-low-density Lipoprotein Particle Remodeling
High-density Lipoprotein Particle Remodeling
Chylomicron Assembly
High-density Lipoprotein Particle Assembly
Negative Regulation Of Plasma Lipoprotein Particle Oxidation
Response To Stilbenoid
Lipoprotein Metabolic Process
Cholesterol Homeostasis
Hydrogen Peroxide Catabolic Process
Reverse Cholesterol Transport
Multicellular Organismal Lipid Catabolic Process
Small Molecule Metabolic Process
Positive Regulation Of Fatty Acid Biosynthetic Process
Phosphatidylcholine Metabolic Process
Positive Regulation Of Lipoprotein Lipase Activity
Lipid Homeostasis
Protein-lipid Complex Assembly
Triglyceride Homeostasis
Ossification
Cell Migration Involved In Sprouting Angiogenesis
Chondrocyte Differentiation
Complement Receptor Mediated Signaling Pathway
GPI Anchor Release
Negative Regulation Of Cell Proliferation
Insulin Receptor Signaling Pathway
Response To Glucose
Positive Regulation Of Endothelial Cell Migration
Positive Regulation Of Alkaline Phosphatase Activity
Positive Regulation Of Triglyceride Biosynthetic Process
Negative Regulation Of Triglyceride Catabolic Process
Positive Regulation Of Glucose Metabolic Process
Positive Regulation Of High-density Lipoprotein Particle Clearance
Cellular Response To Insulin Stimulus
Cellular Response To Drug
Hematopoietic Stem Cell Migration
Positive Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus
Positive Regulation Of Apoptotic Process
Positive Regulation Of Cytolysis
Phosphatidylcholine Metabolic Process
Positive Regulation Of Membrane Protein Ectodomain Proteolysis
Positive Regulation Of Secretion
Transepithelial Transport
Cellular Response To Calcium Ion
Cellular Response To Cholesterol
Cellular Response To Triglyceride
Cellular Response To PH
Hematopoietic Stem Cell Migration To Bone Marrow
Regulation Of Cellular Response To Insulin Stimulus
Pathways
Drugs
Diseases
GWAS
Cholesterol, total (
19060911
20686565
)
Coronary heart disease (
21378990
)
HDL cholesterol (
20864672
19060906
20686565
)
Hematological and biochemical traits (
20139978
)
Hypertriglyceridemia (
23505323
)
LDL cholesterol (
20864672
19060911
20686565
)
Lipid metabolism phenotypes (
22286219
)
Metabolite levels (
22916037
)
Triglycerides (
19074352
21909109
18193043
18193044
20864672
19060906
19060911
20139978
20686565
)
Hematological and biochemical traits (
20139978
)
Liver enzyme levels (
18940312
)
Liver enzyme levels (alkaline phosphatase) (
22001757
)
Protein-Protein Interactions
1 interactors:
GPLD1
5 interactors:
ALPP
APOA1
APOA4
CD55
GM2A
Entrez ID
337
2822
HPRD ID
00130
03946
Ensembl ID
ENSG00000110244
ENSG00000112293
Uniprot IDs
P80108
PDB IDs
Enriched GO Terms of Interacting Partners
?
GPI Anchor Release
Cellular Response To Triglyceride
Positive Regulation Of High-density Lipoprotein Particle Clearance
Hematopoietic Stem Cell Migration To Bone Marrow
Hematopoietic Stem Cell Migration
Positive Regulation Of Cytolysis
Negative Regulation Of Triglyceride Catabolic Process
Complement Receptor Mediated Signaling Pathway
Response To Triglyceride
Positive Regulation Of Membrane Protein Ectodomain Proteolysis
Transepithelial Transport
Cellular Response To PH
Positive Regulation Of Triglyceride Biosynthetic Process
Positive Regulation Of Alkaline Phosphatase Activity
Cellular Response To Cholesterol
Cellular Response To Sterol
Regulation Of Triglyceride Biosynthetic Process
Cell Migration Involved In Sprouting Angiogenesis
Response To Cholesterol
Positive Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus
Negative Regulation Of Lipid Catabolic Process
Positive Regulation Of Phosphatase Activity
Blood Vessel Endothelial Cell Migration
Positive Regulation Of Glucose Metabolic Process
Regulation Of Triglyceride Metabolic Process
Response To PH
Positive Regulation Of Dephosphorylation
Cellular Response To Calcium Ion
Phosphatidylcholine Metabolic Process
Cellular Response To Drug
Sprouting Angiogenesis
Positive Regulation Of Endothelial Cell Migration
Regulation Of Lipid Catabolic Process
Positive Regulation Of Lipid Biosynthetic Process
GPI Anchor Metabolic Process
Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus
Positive Regulation Of Insulin Secretion
Negative Regulation Of Lipid Metabolic Process
Positive Regulation Of Peptide Hormone Secretion
Endothelial Cell Migration
Positive Regulation Of Peptide Secretion
Positive Regulation Of Epithelial Cell Migration
Regulation Of Cellular Response To Insulin Stimulus
Chondrocyte Differentiation
Epithelial Cell Migration
Regulation Of Phosphatase Activity
Epithelium Migration
Positive Regulation Of Hormone Secretion
Regulation Of Glucose Metabolic Process
Regulation Of Endothelial Cell Migration
High-density Lipoprotein Particle Assembly
Positive Regulation Of Triglyceride Catabolic Process
Positive Regulation Of Cholesterol Esterification
Regulation Of Intestinal Cholesterol Absorption
Regulation Of Cholesterol Esterification
Phospholipid Efflux
Positive Regulation Of Fatty Acid Biosynthetic Process
Positive Regulation Of Lipoprotein Lipase Activity
High-density Lipoprotein Particle Remodeling
Protein-lipid Complex Assembly
Reverse Cholesterol Transport
Positive Regulation Of Lipid Catabolic Process
Plasma Lipoprotein Particle Remodeling
Positive Regulation Of Steroid Metabolic Process
Cholesterol Efflux
Positive Regulation Of Fatty Acid Metabolic Process
Regulation Of Fatty Acid Biosynthetic Process
Cholesterol Biosynthetic Process
Lipid Transport
Regulation Of Triglyceride Metabolic Process
Triglyceride Homeostasis
Acylglycerol Homeostasis
Regulation Of Cholesterol Transport
Lipid Localization
Lipid Storage
Sterol Biosynthetic Process
Neuron Projection Regeneration
Phosphatidylcholine Metabolic Process
Regulation Of Lipid Catabolic Process
Positive Regulation Of Lipid Biosynthetic Process
Regulation Of Plasma Lipoprotein Particle Levels
Sterol Transport
Cholesterol Transport
Phototransduction, Visible Light
Cholesterol Homeostasis
Retinoid Metabolic Process
Sterol Homeostasis
Regulation Of Fatty Acid Metabolic Process
Diterpenoid Metabolic Process
Positive Regulation Of Lipase Activity
Detection Of Visible Light
Phospholipid Transport
Regulation Of Lipid Transport
Phototransduction
Regulation Of Steroid Metabolic Process
Detection Of Light Stimulus
Negative Regulation Of Cell Adhesion Molecule Production
Cholesterol Metabolic Process
Lipid Homeostasis
Steroid Biosynthetic Process
Tagcloud
?
2d
apoa1
biochemistry
bioinformatic
cfhr1
clu
cscc
curative
decyder
dige
dysfunctional
eppk1
erroneous
etc
f2
igk
ingenuity
ipa
maldi
masp2
missed
overrepresented
proteomic
proteomics
quantitatively
spots
suffered
urgent
uyghur
Tagcloud (Difference)
?
2d
apoa1
biochemistry
bioinformatic
cfhr1
clu
cscc
curative
decyder
dige
dysfunctional
eppk1
erroneous
etc
f2
igk
ingenuity
ipa
maldi
masp2
missed
overrepresented
proteomic
proteomics
quantitatively
spots
suffered
urgent
uyghur
Tagcloud (Intersection)
?