COQ4 and COQ7

Number of citations: 55 (PubMedID 27499296)
Data Source: BioGRID (pull down)

		COQ4	COQ7
Name		coenzyme Q4	coenzyme Q7, hydroxylase
Structure		No pdb structure
GO Annotations	Cellular Component	Mitochondrion Mitochondrial Inner Membrane Membrane Extrinsic Component Of Mitochondrial Inner Membrane Protein-containing Complex Ubiquinone Biosynthesis Complex	Nucleus Chromosome Mitochondrion Mitochondrial Inner Membrane Membrane Extrinsic Component Of Mitochondrial Inner Membrane Ubiquinone Biosynthesis Complex
	Molecular Function	Protein Binding Lyase Activity 4-hydroxy-3-methoxy-5-polyprenylbenzoate Decarboxylase Activity	Chromatin Binding Monooxygenase Activity Protein Binding 3-demethoxyubiquinol 3-hydroxylase Activity Oxidoreductase Activity Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen, NAD(P)H As One Donor, And Incorporation Of One Atom Of Oxygen Metal Ion Binding 3-demethoxyubiquinone 3-hydroxylase (NADH) Activity
	Biological Process	Ubiquinone Biosynthetic Process	Negative Regulation Of Transcription By RNA Polymerase II Ubiquinone Biosynthetic Process Determination Of Adult Lifespan Regulation Of Gene Expression Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Reactive Oxygen Species Metabolic Process
Pathways		Ubiquinol biosynthesis	Ubiquinol biosynthesis
GWAS		Body mass index ( 26426971 ) Obesity-related traits ( 23251661 )	Parkinson's disease ( 28892059 )
Novel Interactors		None recorded	1 novel interactors: CPPED1
Interacting Genes		4 interacting genes: COQ7 COQ9 MAGEA2 MAGEA2B	1 interacting genes: COQ4
Entrez ID		51117	10229
HPRD ID		16741	03401
Ensembl ID		ENSG00000167113	ENSG00000167186
Uniprot IDs		Q9Y3A0	Q99807
PDB IDs		Not available	7SSP 7SSS
GO Terms Enriched among Interactors		Negative Regulation Of Protein Acetylation Ubiquinone Biosynthesis Complex Negative Regulation Of Protein Sumoylation Positive Regulation Of Ubiquitin-protein Transferase Activity Ubiquinone Biosynthetic Process Ubiquinone Metabolic Process Quinone Metabolic Process Regulation Of Protein Sumoylation Regulation Of Ubiquitin-protein Transferase Activity Ketone Biosynthetic Process Cellular Senescence Ketone Metabolic Process Negative Regulation Of Post-translational Protein Modification Signal Transduction By P53 Class Mediator Positive Regulation Of Protein Ubiquitination PML Body 3-demethoxyubiquinol 3-hydroxylase Activity 3-demethoxyubiquinone 3-hydroxylase (NADH) Activity Isoprenoid Binding Positive Regulation Of Post-translational Protein Modification Histone Deacetylase Binding DNA-binding Transcription Factor Binding Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Protein Ubiquitination Regulation Of Post-translational Protein Modification Extrinsic Component Of Mitochondrial Inner Membrane Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Ubiquitin Protein Ligase Binding Positive Regulation Of Catalytic Activity Negative Regulation Of RNA Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Protein Modification Process Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen, NAD(P)H As One Donor, And Incorporation Of One Atom Of Oxygen Mitochondrial Inner Membrane Small Molecule Biosynthetic Process Regulation Of Catalytic Activity Negative Regulation Of Protein Metabolic Process Protein Catabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of Protein Modification Process Determination Of Adult Lifespan Negative Regulation Of Biosynthetic Process Mitochondrial Electron Transport, NADH To Ubiquinone Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Macromolecule Metabolic Process Positive Regulation Of Protein Metabolic Process Negative Regulation Of Metabolic Process Monooxygenase Activity Aerobic Electron Transport Chain	4-hydroxy-3-methoxy-5-polyprenylbenzoate Decarboxylase Activity Extrinsic Component Of Mitochondrial Inner Membrane Ubiquinone Biosynthesis Complex Ubiquinone Metabolic Process Ubiquinone Biosynthetic Process Quinone Metabolic Process Ketone Biosynthetic Process Ketone Metabolic Process Protein Serine/threonine Phosphatase Activity Azurophil Granule Lumen Lyase Activity