MXD1 and MOGS

Data Source: HiPPIP (Novel)

		MXD1	MOGS
Name		MAX dimerization protein 1	mannosyl-oligosaccharide glucosidase
Structure			No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Mitochondrion Cytosol Mad-Max Complex	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane Extracellular Exosome
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA Binding Protein Binding Protein Dimerization Activity	Glc3Man9GlcNAc2 Oligosaccharide Glucosidase Activity Glucosidase Activity Hydrolase Activity Hydrolase Activity, Acting On Glycosyl Bonds
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II	Carbohydrate Metabolic Process Protein Folding Protein N-linked Glycosylation Oligosaccharide Metabolic Process Viral Protein Processing
Pathways		None	Defective MOGS causes CDG-2b N-glycan trimming in the ER and Calnexin/Calreticulin cycle Maturation of spike protein Maturation of spike protein Regulation of CDH1 posttranslational processing and trafficking to plasma membrane
Diseases		None	Congenital disorders of glycosylation (CDG) type II
GWAS		Carotid plaque burden (smoking interaction) ( 24954085 ) High light scatter reticulocyte count ( 27863252 32888494 ) Mean platelet volume ( 27863252 32888494 ) Platelet count ( 27863252 32888494 ) Red cell distribution width ( 28957414 ) Reticulocyte count ( 32888494 ) Reticulocyte fraction of red cells ( 32888494 )	No GWAS studies recorded
Novel Interactors		2 novel interactors: MOGS REL	8 novel interactors: C1D ETAA1 EXOC6B MXD1 PCBP1 RAB11FIP5 REL VPS54
Interacting Genes		18 interacting genes: AKT1 APP CD2 HDAC1 HDAC2 MAX MLX MYC MYCL MYCN PML PRAM1 RPS6KA1 RPS6KB1 SAP30 SIN3A SIN3B SMC3	1 interacting genes: CHGB
Entrez ID		4084	7841
HPRD ID		02487	03214
Ensembl ID		ENSG00000059728	ENSG00000115275
Uniprot IDs		B7ZLI7 Q05195	A0A384MDR6 Q13724 Q58F09
PDB IDs		1E91 1G1E 1NLW 1PD7 1S5Q	Not available
GO Terms Enriched among Interactors		Sin3-type Complex Nucleoplasm Chromatin Regulation Of Stem Cell Population Maintenance Negative Regulation Of Stem Cell Population Maintenance Regulation Of Transcription By RNA Polymerase II Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of RNA Metabolic Process Negative Regulation Of Metabolic Process Regulation Of Macromolecule Metabolic Process Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Histone Deacetylase Complex Regulation Of Macromolecule Biosynthetic Process Regulation Of RNA Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Primary Metabolic Process Positive Regulation Of Stem Cell Population Maintenance Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of RNA Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Regulation Of Metabolic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of RNA Biosynthetic Process Epigenetic Regulation Of Gene Expression Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of DNA-templated Transcription Positive Regulation Of Biosynthetic Process Cellular Response To Catecholamine Stimulus Response To Growth Factor Positive Regulation Of RNA Metabolic Process Protein-containing Complex Myc-Max Complex Negative Regulation Of Cell Migration Response To Catecholamine Protein Dimerization Activity Regulation Of Programmed Cell Death Negative Regulation Of Cell Motility Negative Regulation Of Gene Expression Negative Regulation Of Locomotion Regulation Of Developmental Process Regulation Of Multicellular Organismal Process Negative Regulation Of Multicellular Organismal Process Regulation Of Cell Differentiation Positive Regulation Of Nucleobase-containing Compound Metabolic Process Protein Lysine Delactylase Activity	None