MOGS and RAB11FIP5

		MOGS	RAB11FIP5
Description		mannosyl-oligosaccharide glucosidase	RAB11 family interacting protein 5
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane Extracellular Exosome	Golgi Membrane Cytoplasm Mitochondrion Mitochondrial Outer Membrane Endosome Early Endosome Golgi Apparatus Plasma Membrane Cilium Membrane Nuclear Speck Secretory Granule Transport Vesicle Membrane Cytoplasmic Vesicle Early Endosome Membrane Mitochondrial Membrane Centriolar Satellite Ciliary Basal Body Phagocytic Vesicle Recycling Endosome Recycling Endosome Membrane
	Molecular Function	Glc3Man9GlcNAc2 Oligosaccharide Glucosidase Activity Glucosidase Activity Hydrolase Activity Hydrolase Activity, Acting On Glycosyl Bonds	Protein Binding Small GTPase Binding Gamma-tubulin Binding
	Biological Process	Carbohydrate Metabolic Process Protein Folding Protein N-linked Glycosylation Oligosaccharide Metabolic Process Viral Protein Processing	Protein Transport Insulin Secretion Involved In Cellular Response To Glucose Stimulus Regulated Exocytosis Negative Regulation Of Adiponectin Secretion Cellular Response To Acidic PH Regulation Of Protein Localization To Cell Surface
Pathways		Defective MOGS causes CDG-2b N-glycan trimming in the ER and Calnexin/Calreticulin cycle Maturation of spike protein Maturation of spike protein Regulation of CDH1 posttranslational processing and trafficking to plasma membrane
Drugs
Diseases		Congenital disorders of glycosylation (CDG) type II
GWAS			Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Estimated glomerular filtration rate ( 31152163) Non-word reading ( 30741946) Pediatric areal bone mineral density (spine vs radius & hip discordant skeletal phenotype) ( 29240982) Urinary metabolite modules (eigenmetabolites) in chronic kidney disease ( 31959995)
Interacting Genes		1 interacting genes: CHGB	10 interacting genes: ARF6 NAPG RAB11A RAB11B RAB11FIP4 RAB14 RAB25 RO60 TRIM21 YWHAG
Entrez ID		7841	26056
HPRD ID		03214	16117
Ensembl ID		ENSG00000115275	ENSG00000135631
Uniprot IDs		A0A384MDR6 Q13724 Q58F09	A0A1B0GTL5 Q9BXF6
PDB IDs
Enriched GO Terms of Interacting Partners?			Myosin V Binding G Protein Activity Endocytic Recycling Recycling Endosome Membrane Vesicle-mediated Transport To The Plasma Membrane Recycling Endosome Endosomal Transport Protein Localization To Cleavage Furrow GTPase Activity GTP Binding Vesicle-mediated Transport Positive Regulation Of Epithelial Cell Migration Cleavage Furrow Positive Regulation Of Mitotic Cytokinetic Process Establishment Of Protein Localization Golgi Apparatus Amyloid-beta Clearance By Transcytosis Cytoplasmic Vesicle Extracellular Exosome Regulation Of Epithelial Cell Migration GDP Binding Localization Within Membrane Phagocytic Vesicle Regulation Of Cytokinesis Positive Regulation Of Mitotic Cytokinesis Protein Transport Regulation Of Mitotic Cytokinesis Intracellular Protein Localization Positive Regulation Of Cell Cycle Intracellular Transport Transcytosis Regulation Of Endocytic Recycling Endosome Melanosome Transport Establishment Of Melanosome Localization Pigment Granule Transport Melanosome Localization Pigment Granule Localization Protein K6-linked Ubiquitination Amyloid-beta Clearance Protein Localization To Cell Surface Regulation Of Cell Division Regulation Of Protein Localization Cellular Localization Establishment Of Localization In Cell Regulation Of Protein Localization To Cell Surface Exocytosis Vesicle Docking Involved In Exocytosis Hydrolase Activity Intracellular Protein Transport
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