MOGS and C1D

		MOGS	C1D
Description		mannosyl-oligosaccharide glucosidase	C1D nuclear receptor corepressor
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane Extracellular Exosome	Nuclear Exosome (RNase Complex) Exosome (RNase Complex) Nucleus Nucleoplasm Nucleolus Cytoplasm Transcription Repressor Complex
	Molecular Function	Glc3Man9GlcNAc2 Oligosaccharide Glucosidase Activity Glucosidase Activity Hydrolase Activity Hydrolase Activity, Acting On Glycosyl Bonds	DNA Binding Transcription Corepressor Activity RNA Binding Protein Binding Nuclear Receptor Binding
	Biological Process	Carbohydrate Metabolic Process Protein Folding Protein N-linked Glycosylation Oligosaccharide Metabolic Process Viral Protein Processing	Maturation Of 5.8S RRNA RRNA Processing Apoptotic Process Regulation Of Gene Expression Negative Regulation Of DNA-templated Transcription
Pathways		Defective MOGS causes CDG-2b N-glycan trimming in the ER and Calnexin/Calreticulin cycle Maturation of spike protein Maturation of spike protein Regulation of CDH1 posttranslational processing and trafficking to plasma membrane	Major pathway of rRNA processing in the nucleolus and cytosol Nuclear RNA decay
Drugs
Diseases		Congenital disorders of glycosylation (CDG) type II
GWAS			Familial lung adenocarcinoma ( 29924316) Male-pattern baldness ( 27182965) Obstetric antiphospholipid syndrome ( 28424481) PR interval ( 32439900) Restless legs syndrome ( 29029846) Schizophrenia x sex interaction ( 34099189) Systolic blood pressure response to hydrochlorothiazide in hypertension ( 27802415)
Interacting Genes		1 interacting genes: CHGB	15 interacting genes: APP GSC2 IL23R NCOR1 NCOR2 NR1D1 PCBD2 PRKDC SASH1 SH3GLB1 SUOX THRA THRB TSNAX ZGPAT
Entrez ID		7841	10438
HPRD ID		03214	07382
Ensembl ID		ENSG00000115275	ENSG00000197223
Uniprot IDs		A0A384MDR6 Q13724 Q58F09	Q13901
PDB IDs
Enriched GO Terms of Interacting Partners?			Negative Regulation Of MiRNA Transcription Mating Behavior Sequence-specific DNA Binding Chromatin Thyroid Hormone Receptor Signaling Pathway Female Courtship Behavior Positive Regulation Of Thyroid Hormone Receptor Signaling Pathway DNA Binding Reproductive Behavior Thyroid Hormone Binding Hormone-mediated Signaling Pathway Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Thyroid Hormone Receptor Signaling Pathway Nuclear Receptor Activity Negative Regulation Of Macromolecule Metabolic Process Regulation Of Metabolic Process Regulation Of Female Receptivity Female Mating Behavior Type I Pneumocyte Differentiation Negative Regulation Of Metabolic Process Regulation Of MiRNA Transcription Negative Regulation Of Macromolecule Biosynthetic Process Intracellular Receptor Signaling Pathway Negative Regulation Of Biosynthetic Process Regulation Of Macromolecule Metabolic Process Regulation Of MiRNA Metabolic Process Rhythmic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Gene Expression Regulation Of Transcription By RNA Polymerase II Nuclear Receptor-mediated Signaling Pathway Negative Regulation Of Androgen Receptor Signaling Pathway Regulation Of Macromolecule Biosynthetic Process Regulation Of Phosphorus Metabolic Process Negative Regulation Of RNA Metabolic Process Regulation Of Primary Metabolic Process Regulation Of Intracellular Signal Transduction Retinoic Acid Receptor Signaling Pathway Regulation Of Ketone Metabolic Process Regulation Of RNA Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process DNA-binding Transcription Factor Activity Lung Epithelial Cell Differentiation Lung Cell Differentiation Nuclear Body Negative Regulation Of Phosphate Metabolic Process Regulation Of Androgen Receptor Signaling Pathway
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