MOGS and ETAA1

		MOGS	ETAA1
Description		mannosyl-oligosaccharide glucosidase	ETAA1 activator of ATR kinase
Image		No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane Extracellular Exosome	Nucleus Nucleoplasm Cytosol Plasma Membrane Nuclear Speck Nuclear Replication Fork
	Molecular Function	Glc3Man9GlcNAc2 Oligosaccharide Glucosidase Activity Glucosidase Activity Hydrolase Activity Hydrolase Activity, Acting On Glycosyl Bonds	Protein Binding Protein Serine/threonine Kinase Activator Activity
	Biological Process	Carbohydrate Metabolic Process Protein Folding Protein N-linked Glycosylation Oligosaccharide Metabolic Process Viral Protein Processing	G2/M Transition Of Mitotic Cell Cycle DNA Repair DNA Damage Response Replication Fork Processing Mitotic G2/M Transition Checkpoint Positive Regulation Of Protein Serine/threonine Kinase Activity Regulation Of DNA Damage Checkpoint
Pathways		Defective MOGS causes CDG-2b N-glycan trimming in the ER and Calnexin/Calreticulin cycle Maturation of spike protein Maturation of spike protein Regulation of CDH1 posttranslational processing and trafficking to plasma membrane
Drugs
Diseases		Congenital disorders of glycosylation (CDG) type II
GWAS			Adult body size ( 32376654) Body size at age 10 ( 32376654) Endometriosis ( 28537267) Hip circumference adjusted for BMI ( 34021172) Lung adenocarcinoma ( 28604730) Lung cancer ( 28604730) Lung cancer in ever smokers ( 28604730) Male-pattern baldness ( 27182965) Milk allergy ( 25710614) Pancreatic cancer ( 26098869) Periodontitis (CDC/AAP) ( 24024966) Photic sneeze reflex ( 27182965) Systolic blood pressure response to hydrochlorothiazide in hypertension ( 27802415) Vincristine-induced peripheral neuropathy in acute lymphoblastic leukemia ( 25710658) Waist-hip ratio ( 23966867) Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction) ( 28448500) Waist-to-hip ratio adjusted for BMI in active individuals ( 28448500) Waist-to-hip ratio adjusted for body mass index ( 28448500 28430825)
Interacting Genes		1 interacting genes: CHGB	2 interacting genes: ATR ATRIP
Entrez ID		7841	54465
HPRD ID		03214	13282
Ensembl ID		ENSG00000115275	ENSG00000143971
Uniprot IDs		A0A384MDR6 Q13724 Q58F09	Q9NY74
PDB IDs			8JZV
Enriched GO Terms of Interacting Partners?			ATR-ATRIP Complex Establishment Of Protein-containing Complex Localization To Telomere Regulation Of Double-strand Break Repair Establishment Of RNA Localization To Telomere Signal Transduction In Response To DNA Damage DNA Damage Checkpoint Signaling Positive Regulation Of Telomerase Catalytic Core Complex Assembly Glucosidase Activity Glc3Man9GlcNAc2 Oligosaccharide Glucosidase Activity Histone H2AXS139 Kinase Activity Negative Regulation Of Cell Cycle Phase Transition Regulation Of DNA Repair Negative Regulation Of Cell Cycle Process MutSalpha Complex Binding Negative Regulation Of Cell Cycle MutLalpha Complex Binding Protein Localization To Chromosome, Telomeric Region Regulation Of Cell Cycle Phase Transition Regulation Of DNA Metabolic Process Membrane Disassembly Regulation Of Cellular Response To Stress Regulation Of Cellular Response To Heat Nuclear Membrane Disassembly DNA Repair Positive Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator DNA Strand Resection Involved In Replication Fork Processing Replicative Senescence Positive Regulation Of Telomere Maintenance Via Telomerase Nuclear Envelope Organization Negative Regulation Of DNA Replication Positive Regulation Of Telomere Maintenance Via Telomere Lengthening Protein Localization To Site Of Double-strand Break K63-linked Polyubiquitin Modification-dependent Protein Binding Cellular Response To Gamma Radiation Viral Protein Processing Response To Arsenic-containing Substance DNA Metabolic Process Regulation Of Cell Cycle Process Positive Regulation Of Signal Transduction By P53 Class Mediator DNA Damage Response Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Replication Fork Processing Interstrand Cross-link Repair Site Of DNA Damage Regulation Of Telomere Maintenance Via Telomerase Positive Regulation Of DNA Biosynthetic Process Nuclear Membrane Organization Regulation Of Telomere Maintenance Via Telomere Lengthening Response To Gamma Radiation Mitotic G2/M Transition Checkpoint
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