MIR15B and DCP1A

Number of citations of the paper that reports this interaction (PubMedID 28431233)
0

Data Source:
BioGRID (unspecified method)

		MIR15B	DCP1A
Description		microRNA 15b	decapping mRNA 1A
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Space RISC Complex Extracellular Vesicle	P-body Nucleus Cytoplasm Cytosol Membrane Dendrite Cytoplasmic Ribonucleoprotein Granule
	Molecular Function	MRNA 3'-UTR Binding MRNA Base-pairing Post-transcriptional Repressor Activity	MRNA Binding Protein Binding Enzyme Activator Activity Hydrolase Activity Kinesin Binding Identical Protein Binding 5'-(N(7)-methylguanosine 5'-triphospho)-[mRNA] Hydrolase Activity
	Biological Process	Branching Involved In Blood Vessel Morphogenesis Cardiac Muscle Hypertrophy Negative Regulation Of Cell Population Proliferation Negative Regulation Of Angiogenesis Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway MiRNA-mediated Post-transcriptional Gene Silencing MiRNA-mediated Gene Silencing By Inhibition Of Translation Positive Regulation Of Apoptotic Process Negative Regulation Of Canonical NF-kappaB Signal Transduction Negative Regulation Of Neuron Apoptotic Process Negative Regulation Of Blood Vessel Endothelial Cell Migration Negative Regulation Of Glycogen Biosynthetic Process Positive Regulation Of Translation Negative Regulation Of Mitotic Cell Cycle Negative Regulation Of Insulin Receptor Signaling Pathway Negative Regulation Of Inflammatory Response Negative Regulation Of Wound Healing Negative Regulation Of Cellular Response To Insulin Stimulus Negative Regulation Of Trophoblast Cell Migration Negative Regulation Of Non-canonical NF-kappaB Signal Transduction Negative Regulation Of Amyloid-beta Formation Negative Regulation Of Amyloid Precursor Protein Catabolic Process Negative Regulation Of Blood Vessel Endothelial Cell Proliferation Involved In Sprouting Angiogenesis Negative Regulation Of Vascular Endothelial Growth Factor Production Negative Regulation Of Vascular Associated Smooth Muscle Cell Differentiation Positive Regulation Of Connective Tissue Replacement Negative Regulation Of Vascular Endothelial Cell Proliferation Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle	Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Deadenylation-dependent Decapping Of Nuclear-transcribed MRNA Deadenylation-independent Decapping Of Nuclear-transcribed MRNA MRNA Methylguanosine-cap Decapping Protein Localization To Cytoplasmic Stress Granule
Pathways			mRNA decay by 5' to 3' exoribonuclease Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
Drugs
Diseases
GWAS		Bipolar disorder ( 31043756) Malaria ( 31844061)	Body mass index ( 26426971) Electrocardiographic traits ( 25055868) Erosive tooth wear (severe vs non-severe) ( 29898447) Heart rate ( 23583979) PR interval ( 32439900) Refractive error ( 32231278) Spontaneous preterm birth (preterm delivery) ( 25599974)
Interacting Genes		102 interacting genes: ADARB1 AIMP1 APOBEC3B AQR ATXN2L C1QBP CELF1 CPSF1 CSTF3 DARS1 DCP1A DCP1B DCP2 DDX1 DDX21 DDX3X DDX3Y DHX36 DHX37 EDC3 EDC4 EIF2AK2 EPRS1 ERAL1 ESRP1 FAM98A FIP1L1 FUS G3BP2 HNRNPA0 HNRNPA1 HNRNPA2B1 HNRNPA3 HNRNPF HNRNPH1 HNRNPH2 HNRNPH3 HNRNPK HNRNPL HNRNPM HNRNPR IARS1 IGF2BP1 IGF2BP2 IGF2BP3 KARS1 KNOP1 LARP7 LARS1 LIN28A LRPPRC MARS1 MATR3 MSI1 MSI2 NOL6 NONO NUDT21 NUFIP2 PATL1 PDCD11 PLOD1 PRMT1 PTBP1 PTBP3 PUF60 PUM1 PURA QARS1 RARS1 RBFOX2 RBM12B RBM14 RBM4 RBM45 RBMS2 RTCA RTCB SF3A1 SF3B1 SF3B2 SF3B3 SF3B4 SFPQ SPOUT1 STRBP SUGP2 SYMPK SYNCRIP TAF15 TENT2 TRA2A TRA2B U2SURP UPF1 USP36 UTP20 YBX1 YBX2 YBX3 ZFR ZNF346	16 interacting genes: AGO1 AGO2 DCP2 FHL2 LSM8 MAPK3 MIR15B NSMAF PAXIP1 PNRC2 RAD52 RITA1 SMAD4 TTF2 UPF1 YWHAG
Entrez ID		406949	55802
HPRD ID			06113
Ensembl ID		ENSG00000207779	ENSG00000272886
Uniprot IDs			Q9NPI6
PDB IDs			2WX3 4B6H
Enriched GO Terms of Interacting Partners?		RNA Binding Nucleic Acid Binding RNA Metabolic Process RNA Processing MRNA Metabolic Process Nucleic Acid Metabolic Process MRNA Processing RNA Splicing Nucleobase-containing Compound Metabolic Process MRNA Binding Macromolecule Metabolic Process Nucleus Regulation Of RNA Splicing Regulation Of MRNA Metabolic Process Post-transcriptional Regulation Of Gene Expression Nucleoplasm Ribonucleoprotein Complex MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions Aminoacyl-tRNA Synthetase Multienzyme Complex Cytoplasmic Stress Granule Spliceosomal Complex Catalytic Step 2 Spliceosome Regulation Of Translation P-body MRNA 3'-UTR Binding Regulation Of MRNA Processing Regulation Of MRNA Splicing, Via Spliceosome MiRNA Binding Negative Regulation Of MRNA Metabolic Process Regulation Of Gene Expression Negative Regulation Of RNA Catabolic Process Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Translation Regulation Of MRNA Stability Regulation Of RNA Stability Regulation Of Macromolecule Metabolic Process Negative Regulation Of MRNA Catabolic Process RNA Stabilization TRNA Aminoacylation For Protein Translation Aminoacyl-tRNA Ligase Activity Negative Regulation Of Macromolecule Metabolic Process TRNA Aminoacylation MRNA Stabilization Negative Regulation Of Gene Expression Regulation Of Alternative MRNA Splicing, Via Spliceosome Negative Regulation Of Metabolic Process MRNA Methylguanosine-cap Decapping Positive Regulation Of Cytoplasmic Translation RNA Decapping	P-body Nucleic Acid Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Nucleobase-containing Compound Metabolic Process RNA Metabolic Process MRNA Destabilization RISC Complex RNA Destabilization Nuclear-transcribed MRNA Catabolic Process Positive Regulation Of MRNA Catabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Metabolic Process MRNA Catabolic Process SiRNA-mediated Gene Silencing By MRNA Destabilization Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Negative Regulation Of Biosynthetic Process Positive Regulation Of MRNA Metabolic Process Negative Regulation Of Protein Metabolic Process Post-transcriptional Regulation Of Gene Expression MRNA Metabolic Process MiRNA-mediated Gene Silencing By Inhibition Of Translation Nucleoplasm Regulation Of Primary Metabolic Process Regulation Of Metabolic Process Negative Regulation Of Translation RISC-loading Complex Regulation Of Protein Metabolic Process Regulation Of MRNA Stability RNA Catabolic Process Regulation Of Translation Regulation Of RNA Stability Negative Regulation Of Gene Expression RISC Complex Assembly Negative Regulation Of T Cell Mediated Immune Response To Tumor Cell Nucleus Positive Regulation Of Gene Expression Cytoplasmic Ribonucleoprotein Granule Regulation Of DNA Metabolic Process Regulation Of Macromolecule Metabolic Process Negative Regulation Of Immune Response To Tumor Cell Pre-miRNA Processing Histone MRNA Catabolic Process Regulation Of T Cell Mediated Immune Response To Tumor Cell Regulation Of Gene Expression Regulation Of Trophoblast Cell Migration MRNA Methylguanosine-cap Decapping Positive Regulation Of Catabolic Process Regulation Of Macromolecule Biosynthetic Process Core Promoter Sequence-specific DNA Binding Regulation Of Telomere Maintenance
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?