MIR15B and DHX36

Number of citations of the paper that reports this interaction (PubMedID 28431233)
0

Data Source:
BioGRID (unspecified method)

		MIR15B	DHX36
Description		microRNA 15b	DEAH-box helicase 36
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Space RISC Complex Extracellular Vesicle	Chromosome, Telomeric Region Nucleus Nucleoplasm Chromosome Cytoplasm Mitochondrion Cytosol Cytoplasmic Stress Granule Nuclear Speck Axon Dendrite Cell Projection Perikaryon Extracellular Exosome
	Molecular Function	MRNA 3'-UTR Binding MRNA Base-pairing Post-transcriptional Repressor Activity	Nucleotide Binding Magnesium Ion Binding Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding G-quadruplex RNA Binding Nucleic Acid Binding DNA Binding DNA Helicase Activity Single-stranded DNA Binding RNA Binding RNA Helicase Activity Double-stranded RNA Binding MRNA 3'-UTR Binding Helicase Activity Protein Binding ATP Binding ATP-dependent Activity, Acting On DNA Hydrolase Activity ATP Hydrolysis Activity MRNA 3'-UTR AU-rich Region Binding Histone Deacetylase Binding Metal Ion Binding MRNA 5'-UTR Binding G-quadruplex DNA Binding Telomerase RNA Binding Pre-miRNA Binding Catalytic Activity, Acting On A Nucleic Acid
	Biological Process	Branching Involved In Blood Vessel Morphogenesis Cardiac Muscle Hypertrophy Negative Regulation Of Cell Population Proliferation Negative Regulation Of Angiogenesis Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway MiRNA-mediated Post-transcriptional Gene Silencing MiRNA-mediated Gene Silencing By Inhibition Of Translation Positive Regulation Of Apoptotic Process Negative Regulation Of Canonical NF-kappaB Signal Transduction Negative Regulation Of Neuron Apoptotic Process Negative Regulation Of Blood Vessel Endothelial Cell Migration Negative Regulation Of Glycogen Biosynthetic Process Positive Regulation Of Translation Negative Regulation Of Mitotic Cell Cycle Negative Regulation Of Insulin Receptor Signaling Pathway Negative Regulation Of Inflammatory Response Negative Regulation Of Wound Healing Negative Regulation Of Cellular Response To Insulin Stimulus Negative Regulation Of Trophoblast Cell Migration Negative Regulation Of Non-canonical NF-kappaB Signal Transduction Negative Regulation Of Amyloid-beta Formation Negative Regulation Of Amyloid Precursor Protein Catabolic Process Negative Regulation Of Blood Vessel Endothelial Cell Proliferation Involved In Sprouting Angiogenesis Negative Regulation Of Vascular Endothelial Growth Factor Production Negative Regulation Of Vascular Associated Smooth Muscle Cell Differentiation Positive Regulation Of Connective Tissue Replacement Negative Regulation Of Vascular Endothelial Cell Proliferation Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle	Ossification Immune System Process Positive Regulation Of Myeloid Dendritic Cell Cytokine Production Regulation Of Transcription By RNA Polymerase III Regulation Of Translation Spermatogenesis Response To Virus Positive Regulation Of Gene Expression Negative Regulation Of Translation Cell Differentiation Positive Regulation Of MRNA 3'-end Processing Positive Regulation Of Telomere Maintenance Positive Regulation Of Interferon-alpha Production Cellular Response To Heat Cellular Response To UV Positive Regulation Of Canonical NF-kappaB Signal Transduction Response To Exogenous DsRNA Regulation Of MRNA Stability Innate Immune Response Positive Regulation Of Translation Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Embryonic Development Defense Response To Virus Positive Regulation Of Cardioblast Differentiation Positive Regulation Of Transcription Initiation By RNA Polymerase II Positive Regulation Of Dendritic Spine Morphogenesis 3'-UTR-mediated MRNA Destabilization Telomerase RNA Stabilization Positive Regulation Of Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Positive Regulation Of Hematopoietic Progenitor Cell Differentiation Cellular Response To Arsenite Ion Positive Regulation Of Telomere Maintenance Via Telomere Lengthening Positive Regulation Of Intracellular MRNA Localization Positive Regulation Of Cytoplasmic Translation
Pathways			DEx/H-box helicases activate type I IFN and inflammatory cytokines production
Drugs
Diseases
GWAS		Bipolar disorder ( 31043756) Malaria ( 31844061)	Body mass index ( 29273807) Response to cognitive-behavioural therapy in anxiety disorder ( 31123309)
Interacting Genes		102 interacting genes: ADARB1 AIMP1 APOBEC3B AQR ATXN2L C1QBP CELF1 CPSF1 CSTF3 DARS1 DCP1A DCP1B DCP2 DDX1 DDX21 DDX3X DDX3Y DHX36 DHX37 EDC3 EDC4 EIF2AK2 EPRS1 ERAL1 ESRP1 FAM98A FIP1L1 FUS G3BP2 HNRNPA0 HNRNPA1 HNRNPA2B1 HNRNPA3 HNRNPF HNRNPH1 HNRNPH2 HNRNPH3 HNRNPK HNRNPL HNRNPM HNRNPR IARS1 IGF2BP1 IGF2BP2 IGF2BP3 KARS1 KNOP1 LARP7 LARS1 LIN28A LRPPRC MARS1 MATR3 MSI1 MSI2 NOL6 NONO NUDT21 NUFIP2 PATL1 PDCD11 PLOD1 PRMT1 PTBP1 PTBP3 PUF60 PUM1 PURA QARS1 RARS1 RBFOX2 RBM12B RBM14 RBM4 RBM45 RBMS2 RTCA RTCB SF3A1 SF3B1 SF3B2 SF3B3 SF3B4 SFPQ SPOUT1 STRBP SUGP2 SYMPK SYNCRIP TAF15 TENT2 TRA2A TRA2B U2SURP UPF1 USP36 UTP20 YBX1 YBX2 YBX3 ZFR ZNF346	72 interacting genes: DUX4 IL7R MIR1-1 MIR1-2 MIR106A MIR106B MIR107 MIR10B MIR128-1 MIR128-2 MIR138-1 MIR138-2 MIR141 MIR143 MIR145 MIR155 MIR15A MIR15B MIR16-1 MIR16-2 MIR17 MIR18A MIR18B MIR199A1 MIR199A2 MIR19A MIR19B1 MIR19B2 MIR200A MIR200B MIR200C MIR205 MIR206 MIR20A MIR20B MIR21 MIR214 MIR221 MIR222 MIR25 MIR29A MIR29B1 MIR29C MIR31 MIR34A MIR34B MIR34C MIR363 MIR429 MIR451A MIR7-1 MIR7-2 MIR7-3 MIR9-1 MIR9-2 MIR92A1 MIR92A2 MIR93 MIR98 MIRLET7A1 MIRLET7A2 MIRLET7A3 MIRLET7B MIRLET7C MIRLET7D MIRLET7E MIRLET7F2 MIRLET7G MIRLET7I RNF10 TLR1 ZFP36
Entrez ID		406949	170506
HPRD ID			09918
Ensembl ID		ENSG00000207779	ENSG00000174953
Uniprot IDs			Q9H2U1
PDB IDs			2N16 2N21 6Q6R
Enriched GO Terms of Interacting Partners?		RNA Binding Nucleic Acid Binding RNA Metabolic Process RNA Processing MRNA Metabolic Process Nucleic Acid Metabolic Process MRNA Processing RNA Splicing Nucleobase-containing Compound Metabolic Process MRNA Binding Macromolecule Metabolic Process Nucleus Regulation Of RNA Splicing Regulation Of MRNA Metabolic Process Post-transcriptional Regulation Of Gene Expression Nucleoplasm Ribonucleoprotein Complex MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions Aminoacyl-tRNA Synthetase Multienzyme Complex Cytoplasmic Stress Granule Spliceosomal Complex Catalytic Step 2 Spliceosome Regulation Of Translation P-body MRNA 3'-UTR Binding Regulation Of MRNA Processing Regulation Of MRNA Splicing, Via Spliceosome MiRNA Binding Negative Regulation Of MRNA Metabolic Process Regulation Of Gene Expression Negative Regulation Of RNA Catabolic Process Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Translation Regulation Of MRNA Stability Regulation Of RNA Stability Regulation Of Macromolecule Metabolic Process Negative Regulation Of MRNA Catabolic Process RNA Stabilization TRNA Aminoacylation For Protein Translation Aminoacyl-tRNA Ligase Activity Negative Regulation Of Macromolecule Metabolic Process TRNA Aminoacylation MRNA Stabilization Negative Regulation Of Gene Expression Regulation Of Alternative MRNA Splicing, Via Spliceosome Negative Regulation Of Metabolic Process MRNA Methylguanosine-cap Decapping Positive Regulation Of Cytoplasmic Translation RNA Decapping	MiRNA-mediated Post-transcriptional Gene Silencing Regulatory NcRNA-mediated Post-transcriptional Gene Silencing Post-transcriptional Gene Silencing RISC Complex Regulatory NcRNA-mediated Gene Silencing MRNA Base-pairing Post-transcriptional Repressor Activity Post-transcriptional Regulation Of Gene Expression Negative Regulation Of Gene Expression MRNA 3'-UTR Binding MiRNA-mediated Gene Silencing By Inhibition Of Translation Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Metabolic Process MiRNA-mediated Gene Silencing By MRNA Destabilization Extracellular Vesicle Negative Regulation Of Translation Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process MRNA Destabilization RNA Destabilization Positive Regulation Of MRNA Catabolic Process Regulation Of Macromolecule Metabolic Process Negative Regulation Of Angiogenesis Negative Regulation Of Vasculature Development Regulation Of Angiogenesis Negative Regulation Of Cell Migration Regulation Of Vasculature Development Positive Regulation Of MRNA Metabolic Process Negative Regulation Of Cytokine Production Negative Regulation Of Cell Motility Regulation Of Metabolic Process Negative Regulation Of Locomotion Regulation Of Translation Regulation Of MRNA Stability Negative Regulation Of Multicellular Organismal Process Negative Regulation Of Developmental Process Regulation Of RNA Stability Negative Regulation Of Protein Metabolic Process Negative Regulation Of Vascular Endothelial Growth Factor Production Regulation Of Blood Vessel Endothelial Cell Migration Regulation Of Endothelial Cell Migration Extracellular Space Negative Regulation Of Blood Vessel Endothelial Cell Migration Negative Regulation Of Endothelial Cell Migration Regulation Of MRNA Metabolic Process Regulation Of Cytokine Production Regulation Of Cell Migration Regulation Of Cell Motility Regulation Of Anatomical Structure Morphogenesis
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