MIRLET7A2 and PUM2

Number of citations of the paper that reports this interaction (PubMedID 28431233)
0

Data Source:
BioGRID (unspecified method)

		MIRLET7A2	PUM2
Description		microRNA let-7a-2	pumilio RNA binding family member 2
Image		No pdb structure
GO Annotations	Cellular Component	RISC Complex	Cytoplasm Cytosol Cytoplasmic Stress Granule Nuclear Membrane Neuronal Cell Body Perinuclear Region Of Cytoplasm Postsynapse Glutamatergic Synapse
	Molecular Function		RNA Binding MRNA 3'-UTR Binding Protein Binding MiRNA Binding Pumilio-response Element Binding LncRNA Binding
	Biological Process	MiRNA-mediated Post-transcriptional Gene Silencing	Skeletal System Development Hair Follicle Development Regulation Of Translation Mitochondrion Organization Post-transcriptional Regulation Of Gene Expression Negative Regulation Of Gene Expression Respiratory Electron Transport Chain Stress Granule Assembly MiRNA Processing Regulation Of MRNA Stability Positive Regulation Of Sprouting Of Injured Axon Chromosome Organization Regulation Of Chromosome Segregation Adipose Tissue Development Regulation Of MiRNA-mediated Gene Silencing 3'-UTR-mediated MRNA Destabilization Regulation Of Postsynapse Assembly Positive Regulation Of RIG-I Signaling Pathway Regulation Of Intracellular MRNA Localization Positive Regulation Of MiRNA-mediated Gene Silencing
Pathways			Neddylation
Drugs
Diseases
GWAS			Apolipoprotein A1 levels ( 32203549) Apolipoprotein B levels ( 32203549) Appendicular lean mass ( 33097823) Body mass index ( 28892062) Low density lipoprotein cholesterol levels ( 32154731)
Interacting Genes		95 interacting genes: AIMP1 AIMP2 APOBEC3B AQR ATXN2L C1QBP CDC40 CDC5L CHERP DARS1 DDX1 DDX21 DDX23 DDX3X DHX36 EIF2AK2 EPRS1 ERAL1 ESRP1 FAM98A FAM98B FUS G3BP2 GRSF1 HNRNPA0 HNRNPA1 HNRNPA2B1 HNRNPA3 HNRNPF HNRNPH1 HNRNPH2 HNRNPH3 HNRNPK HNRNPL HNRNPM HNRNPR IARS1 IGF2BP1 IGF2BP2 IGF2BP3 KARS1 LARS1 LIN28A LIN28B LRPPRC MARS1 MATR3 MSI1 MSI2 NOL6 NONO NUDT16L1 NUDT21 NUFIP2 P3H1 PDCD11 PGAM5 PLOD1 PLRG1 PRMT1 PTBP1 PTCD3 PUM1 PUM2 QARS1 RARS1 RBM14 RBM17 RBM4 RTCB SAFB SF3A1 SF3A3 SF3B1 SF3B2 SF3B3 SF3B4 SFPQ SPOUT1 STRBP SUGP2 SYMPK SYNCRIP TAF15 TRA2A TRA2B TUT4 TUT7 U2SURP UPF1 UTP20 YBX1 YBX2 YBX3 ZFR	25 interacting genes: AURKA COPS5 DAZ1 DAZ3 DAZ4 DAZL MED23 MED4 MIR128-2 MIR17 MIR199A1 MIR199A2 MIR214 MIR221 MIR7-1 MIR92A2 MIRLET7A1 MIRLET7A2 MIRLET7A3 MIRLET7B MIRLET7E MIRLET7F1 MIRLET7F2 MIRLET7G NANOS1
Entrez ID		406882	23369
HPRD ID			09527
Ensembl ID		ENSG00000198975	ENSG00000055917
Uniprot IDs			B7ZL34 Q8TB72
PDB IDs			3Q0Q 3Q0R 3Q0S
Enriched GO Terms of Interacting Partners?		RNA Binding Nucleic Acid Binding RNA Processing RNA Metabolic Process RNA Splicing Nucleic Acid Metabolic Process MRNA Metabolic Process MRNA Processing Nucleobase-containing Compound Metabolic Process MRNA Binding MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions Spliceosomal Complex Macromolecule Metabolic Process Catalytic Step 2 Spliceosome Post-transcriptional Regulation Of Gene Expression Regulation Of MRNA Metabolic Process Aminoacyl-tRNA Synthetase Multienzyme Complex Nucleoplasm Nucleus MiRNA Binding Cytoplasmic Stress Granule Regulation Of RNA Splicing Regulation Of Translation Ribonucleoprotein Complex MRNA 3'-UTR Binding Negative Regulation Of MRNA Metabolic Process Regulation Of RNA Stability Regulation Of MRNA Stability Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of RNA Catabolic Process Regulation Of MRNA Processing MiRNA Processing Negative Regulation Of MRNA Catabolic Process Regulation Of Macromolecule Metabolic Process RNA Stabilization TRNA Aminoacylation For Protein Translation Aminoacyl-tRNA Ligase Activity TRNA Metabolic Process TRNA Aminoacylation MRNA Stabilization U2 SnRNP Regulation Of Primary Metabolic Process Regulation Of Metabolic Process Positive Regulation Of Cytoplasmic Translation Negative Regulation Of Translation Regulation Of MRNA Splicing, Via Spliceosome Positive Regulation Of Gene Expression CRD-mediated MRNA Stabilization	RISC Complex MiRNA-mediated Post-transcriptional Gene Silencing Regulatory NcRNA-mediated Post-transcriptional Gene Silencing Post-transcriptional Gene Silencing Post-transcriptional Regulation Of Gene Expression Regulatory NcRNA-mediated Gene Silencing MRNA Base-pairing Post-transcriptional Repressor Activity Negative Regulation Of Gene Expression Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Metabolic Process Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Regulation Of MRNA Stability Regulation Of RNA Stability Regulation Of Macromolecule Metabolic Process Regulation Of Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Regulation Of MRNA Metabolic Process MRNA 3'-UTR Binding Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Translation Activator Activity Regulation Of Translation Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway 3'-UTR-mediated MRNA Stabilization Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Extracellular Vesicle MiRNA-mediated Gene Silencing By MRNA Destabilization MRNA Destabilization RNA Destabilization Positive Regulation Of Cardiac Muscle Hypertrophy In Response To Stress Regulation Of Protein Metabolic Process Regulation Of Cellular Response To Growth Factor Stimulus Negative Regulation Of Leukocyte Adhesion To Vascular Endothelial Cell Positive Regulation Of Connective Tissue Replacement Positive Regulation Of MRNA Catabolic Process Positive Regulation Of Translational Initiation Regulation Of Blood Vessel Endothelial Cell Migration MiRNA-mediated Gene Silencing By Inhibition Of Translation Negative Regulation Of Blood Vessel Endothelial Cell Migration Regulation Of Connective Tissue Replacement Regulation Of Cell Migration Involved In Sprouting Angiogenesis Positive Regulation Of MRNA Metabolic Process MRNA Stabilization Regulation Of Cardiac Muscle Hypertrophy In Response To Stress Negative Regulation Of Endothelial Cell Migration Positive Regulation Of Tissue Remodeling Negative Regulation Of MRNA Catabolic Process RNA Stabilization
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