LY9 and SH2D1A

Number of citations: 0 (PubMedID 11477068)
Data Source: HPRD (in vivo, in vitro)

		LY9	SH2D1A
Name		lymphocyte antigen 9	SH2 domain containing 1A
Structure		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane External Side Of Plasma Membrane Cell Surface Membrane	Cytoplasm Cytosol
	Molecular Function	None	Protein Binding Protein-macromolecule Adaptor Activity
	Biological Process	Adaptive Immune Response Immune System Process Immune Response Cell Adhesion Positive Regulation Of Interleukin-17 Production T Cell Activation Innate Immune Response T-helper 17 Cell Lineage Commitment	Adaptive Immune Response Immune System Process Humoral Immune Response Cellular Defense Response Cell-cell Signaling Natural Killer Cell Activation Natural Killer Cell Mediated Cytotoxicity Innate Immune Response Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity Regulation Of Immune Response Negative Regulation Of T Cell Receptor Signaling Pathway
Pathways		None	Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Diseases		None	Other well-defined immunodeficiency syndromes, including the following seven diseases: Wiskott-Aldrich syndrome; DiGeorge syndrome; Hyper-IgE syndrome; X-linked lymphoproliferative syndrome; Immunodeficiency, Polyendocrinopathy, Enteropathy, X-linked Syndrome (IPEX); Cartilage-Hair Hypoplasia; Autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED)
GWAS		Lymphocyte count ( 27863252 32888494 ) Lymphocyte percentage of white cells ( 27863252 32888494 ) White blood cell count ( 32888494 )	No GWAS studies recorded
Novel Interactors		2 novel interactors: CD48 KPLCE	1 novel interactors: CD244
Interacting Genes		3 interacting genes: AP2M1 SH2D1A SH2D1B	32 interacting genes: AR ARHGEF6 ARHGEF7 ATF3 CCDC74A CD84 DOK1 EGFR ERBB2 ERBB3 ERBB4 FYB1 FYN GRB2 KIT LCK LETMD1 LHX3 LHX4 LY9 MAPK11 MAPK14 MET NCK1 NGEF OLIG1 PTK2 SLAMF1 SLAMF6 SLAMF7 TNK2 ZNHIT1
Entrez ID		4063	4068
HPRD ID		02817	02390
Ensembl ID		ENSG00000122224	ENSG00000183918
Uniprot IDs		A0A0C4DFU4 Q05CA2 Q0VAI0 Q5VYH9 Q9HBG7	O60880
PDB IDs		Not available	1D1Z 1D4T 1D4W 1KA6 1KA7 1M27
GO Terms Enriched among Interactors		Natural Killer Cell Activation Regulation Of Natural Killer Cell Mediated Immunity Positive Regulation Of Natural Killer Cell Mediated Immunity Leukocyte Activation Cell Activation Positive Regulation Of Lymphocyte Mediated Immunity Positive Regulation Of Synaptic Vesicle Endocytosis Positive Regulation Of Synaptic Vesicle Recycling Postsynaptic Neurotransmitter Receptor Internalization Signal Sequence Binding Extrinsic Component Of Presynaptic Endocytic Zone Membrane Positive Regulation Of Immune Effector Process Protein-macromolecule Adaptor Activity Regulation Of Lymphocyte Mediated Immunity Immune Response Adaptive Immune Response Positive Regulation Of Innate Immune Response AP-2 Adaptor Complex Clathrin Adaptor Complex Defense Response Clathrin Adaptor Activity Endolysosome Membrane Regulation Of Vesicle Size Immune Effector Process Lymphocyte Activation Clathrin-coated Endocytic Vesicle Regulation Of Synaptic Vesicle Endocytosis Regulation Of Innate Immune Response Positive Regulation Of Defense Response Positive Regulation Of Receptor Internalization Low-density Lipoprotein Particle Receptor Binding Negative Regulation Of Protein Localization To Plasma Membrane Clathrin-dependent Endocytosis Disordered Domain Specific Binding Regulation Of Synaptic Vesicle Recycling Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity Negative Regulation Of T Cell Receptor Signaling Pathway Vesicle Budding From Membrane Immune System Process Synaptic Vesicle Endocytosis Natural Killer Cell Mediated Cytotoxicity Presynaptic Endocytosis Natural Killer Cell Mediated Immunity Innate Immune Response Positive Regulation Of Immune Response Cellular Defense Response Regulation Of T Cell Receptor Signaling Pathway Positive Regulation Of Receptor-mediated Endocytosis Regulation Of Natural Killer Cell Mediated Cytotoxicity	Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Protein Tyrosine Kinase Activity Lymphocyte Activation Positive Regulation Of Metabolic Process Cell Activation Protein Kinase Activity T Cell Activation Cell Surface Receptor Signaling Pathway Cellular Developmental Process Leukocyte Activation Kinase Activity Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of Biosynthetic Process Cell Differentiation Regulation Of Immune System Process ERBB Signaling Pathway Positive Regulation Of Multicellular Organismal Process Positive Regulation Of Gene Expression Regulation Of Programmed Cell Death Regulation Of Intracellular Signal Transduction Regulation Of MAPK Cascade Protein Phosphatase Binding Regulation Of Multicellular Organismal Process Intracellular Signaling Cassette Intracellular Signal Transduction Peptidyl-tyrosine Phosphorylation Ephrin Receptor Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Activity Signal Transduction ERBB2 Signaling Pathway Positive Regulation Of MAPK Cascade Basal Plasma Membrane Ephrin Receptor Binding Regulation Of Metabolic Process Immune Response-activating Cell Surface Receptor Signaling Pathway Negative Regulation Of Programmed Cell Death Immune System Process Positive Regulation Of Cell Population Proliferation Positive Regulation Of Intracellular Signal Transduction Lamellipodium Assembly Animal Organ Development Immune Response-regulating Signaling Pathway Regulation Of Immune Response Regulation Of Apoptotic Process SH2 Domain Binding Adaptive Immune Response