SIM1 and ARNT2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (fluorescent resonance energy transfer, two hybrid)

		SIM1	ARNT2
Description		SIM bHLH transcription factor 1	aryl hydrocarbon receptor nuclear translocator 2
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus	Chromatin Nucleus Nucleoplasm Transcription Regulator Complex Cytoplasm Aryl Hydrocarbon Receptor Complex
	Molecular Function	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Protein Heterodimerization Activity Protein Dimerization Activity	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Aryl Hydrocarbon Receptor Binding Protein-containing Complex Binding Protein Heterodimerization Activity Protein Dimerization Activity Sequence-specific Double-stranded DNA Binding
	Biological Process	Ureteric Bud Development Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Nervous System Development Cell Differentiation System Development	Response To Hypoxia In Utero Embryonic Development Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Central Nervous System Development Brain Development Positive Regulation Of Cell Population Proliferation Response To Estradiol Negative Regulation Of Apoptotic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II
Pathways			PPARA activates gene expression Phase I - Functionalization of compounds Endogenous sterols Xenobiotics Aryl hydrocarbon receptor signalling NPAS4 regulates expression of target genes NPAS4 regulates expression of target genes
Drugs
Diseases
GWAS		Body size at age 10 ( 32376654) Creatinine levels ( 29403010) Erectile dysfunction ( 30297428) Estimated glomerular filtration rate ( 31152163) Femur bone mineral density x serum urate levels interaction ( 34046847) Gait speed in old age ( 28077804) Glomerular filtration rate ( 29403010) Iris color (L* coordinate) ( 30895295) Irritable mood ( 29500382) LDL cholesterol levels in current drinkers ( 30698716) LDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) LDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Major depressive disorder ( 27479909) Menarche (age at onset) ( 25231870) Neurociticism ( 29500382) Neuroticism ( 29255261) Sociability score ( 34054130) Waist-to-hip ratio adjusted for BMI x sex interaction ( 26426971)	Atrial fibrillation ( 29892015 30061737) Attention deficit hyperactivity disorder ( 29325848) Bipolar disorder ( 20351715) Body mass index ( 26426971) Gut microbiota relative abundance (unclassified genus belonging to family Erysipelotrichaceae) ( 33208821) HDL cholesterol levels x long total sleep time interaction (2df test) ( 31719535) Post bronchodilator FEV1 ( 26634245) Post bronchodilator FEV1/FVC ratio ( 26634245)
Interacting Genes		3 interacting genes: ARNT ARNT2 HSP90AA1	69 interacting genes: ADAMTSL4 AHR AP1M1 AP3M1 APP ARNT CALCOCO2 CAPN7 CCDC33 CDR2 CEP57L1 CEP63 CTBP1 DGCR6 DTX2 DYDC1 EPAS1 FAAP20 GOLGA2 HIF1A IKZF3 KIFC3 LMO2 LMO4 LZTS2 MAGEA4 MAGED1 MEIS2 MEOX2 MIPOL1 MTDH MTUS2 NCOA3 NDE1 NPAS2 NPAS4 OSGIN1 PDE4DIP PLSCR1 PSMB1 RBCK1 REL RFX6 RIMBP3 RINT1 SH3GL2 SIM1 SORBS3 SPAG5 SSBP3 SSX2IP STK16 SYCE1 TACC3 TADA2A TAX1BP3 TFIP11 TRAF1 TRAF2 TRIM23 TRIM27 TRIM37 TRIM42 TRIP6 TSPOAP1 USHBP1 USP7 VPS52 ZNF341
Entrez ID		6492	9915
HPRD ID		07049	06915
Ensembl ID		ENSG00000112246	ENSG00000172379
Uniprot IDs		P81133	Q86TN1 Q9HBZ2 X5DQN9
PDB IDs
Enriched GO Terms of Interacting Partners?		Aryl Hydrocarbon Receptor Binding Aryl Hydrocarbon Receptor Complex Positive Regulation Of Erythrocyte Differentiation Response To Hypoxia Response To Decreased Oxygen Levels Response To Oxygen Levels Regulation Of Erythrocyte Differentiation Positive Regulation Of Catabolic Process Sequence-specific Double-stranded DNA Binding Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Myeloid Cell Differentiation DNA-binding Transcription Factor Activity CTP Binding DATP Binding Nuclear Aryl Hydrocarbon Receptor Complex Positive Regulation Of Muscle Atrophy Initiation Of Primordial Ovarian Follicle Growth Cellular Response To Corticosterone Stimulus Neurofibrillary Tangle Assembly UTP Binding Sulfonylurea Receptor Binding Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Biosynthetic Process Protein Dimerization Activity RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Response To Water-immersion Restraint Stress Rho GDP-dissociation Inhibitor Binding Regulation Of Myeloid Cell Differentiation Chromatin Cellular Response To Oxidative Stress DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Mitochondrial Transcription Factor Activity Antral Ovarian Follicle Growth Transcription Regulator Complex Positive Regulation Of Macromolecule Metabolic Process Response To Stress Regulation Of Post-translational Protein Modification Positive Regulation Of Hydrogen Peroxide-mediated Programmed Cell Death Sperm Mitochondrial Sheath Regulation Of Muscle System Process Telomerase Holoenzyme Complex Assembly Cellular Response To Chemical Stress Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Metabolic Process Intestinal Epithelial Structure Maintenance RNA Polymerase II Transcription Repressor Complex Response To Xenobiotic Stimulus Mitochondrial Transcription Chaperone-mediated Autophagy Nitric-oxide Synthase Regulator Activity	Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Transcription By RNA Polymerase II Protein Binding Positive Regulation Of Macromolecule Biosynthetic Process Transcription Coactivator Activity Positive Regulation Of Biosynthetic Process Transcription Regulator Complex Protein Dimerization Activity Regulation Of RNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Metabolic Process Cytoplasm Positive Regulation Of Transcription By RNA Polymerase II RNA Polymerase II-specific DNA-binding Transcription Factor Binding Positive Regulation Of Macromolecule Metabolic Process Nuclear Aryl Hydrocarbon Receptor Complex Nucleus Microtubule Organizing Center Organization DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Centrosome Protein Heterodimerization Activity DNA-binding Transcription Factor Activity Chromatin Microtubule-based Process Positive Regulation Of Autophagy Regulation Of Primary Metabolic Process Establishment Of Localization In Cell Benzodiazepine Receptor Binding Positive Regulation Of Glycolytic Process Embryonic Placenta Development Regulation Of Macromolecule Biosynthetic Process Cytoskeleton Intracellular Transport Regulation Of Gene Expression Tumor Necrosis Factor Receptor Binding Positive Regulation Of NF-kappaB Transcription Factor Activity Cis-regulatory Region Sequence-specific DNA Binding Regulation Of Macromolecule Metabolic Process Aryl Hydrocarbon Receptor Complex Regulation Of Metabolic Process Intestinal Epithelial Structure Maintenance Positive Regulation Of ATP Metabolic Process Microtubule RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Identical Protein Binding
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?