FZD8

Gene Name		frizzled class receptor 8
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Golgi Apparatus Plasma Membrane Integral Component Of Membrane
	Molecular Function	G-protein Coupled Receptor Activity Receptor Binding Protein Binding Wnt-protein Binding PDZ Domain Binding Ubiquitin Protein Ligase Binding Wnt-activated Receptor Activity
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Angiogenesis G-protein Coupled Receptor Signaling Pathway Neuron Differentiation T Cell Differentiation In Thymus Non-canonical Wnt Signaling Pathway Positive Regulation Of JUN Kinase Activity Positive Regulation Of Transcription From RNA Polymerase II Promoter Canonical Wnt Signaling Pathway
Pathways		Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling Signaling by Wnt GPCR ligand binding Metabolic disorders of biological oxidation enzymes beta-catenin independent WNT signaling TCF dependent signaling in response to WNT RNF mutants show enhanced WNT signaling and proliferation regulation of FZD by ubiquitination Asymmetric localization of PCP proteins XAV939 inhibits tankyrase, stabilizing AXIN Signaling by WNT in cancer PCP/CE pathway Class B/2 (Secretin family receptors)
Drugs
Diseases
GWAS		Antineutrophil cytoplasmic antibody-associated vasculitis ( 22808956) Periodontal microbiota ( 22699663) Protein quantitative trait loci ( 18464913)
Protein-protein Interactions		5 interactors: GOPC LRP5 LRP6 RYK WNT1
Entrez ID		8325
HPRD ID		05852
Ensembl ID		ENSG00000177283
Uniprot IDs		Q9H461
PDB IDs
Enriched GO Terms of Interacting Partners?		Wnt Signaling Pathway Wnt Signaling Pathway Involved In Dorsal/ventral Axis Specification Canonical Wnt Signaling Pathway Axis Specification Positive Regulation Of Canonical Wnt Signaling Pathway Regulation Of Fat Cell Differentiation Midbrain-hindbrain Boundary Development Positive Regulation Of Wnt Signaling Pathway Embryonic Retina Morphogenesis In Camera-type Eye Cell Migration Involved In Gastrulation Rostrocaudal Neural Tube Patterning Branching Morphogenesis Of An Epithelial Tube Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Regulation Of Canonical Wnt Signaling Pathway Bone Development Dorsal/ventral Axis Specification Morphogenesis Of A Branching Epithelium Morphogenesis Of A Branching Structure Anterior/posterior Pattern Specification Regulation Of Wnt Signaling Pathway Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Embryonic Organ Morphogenesis Embryonic Camera-type Eye Morphogenesis Positive Regulation Of Mesenchymal Cell Proliferation Regulation Of Bone Remodeling Embryonic Eye Morphogenesis Regulation Of Mesenchymal Cell Proliferation Branching Involved In Mammary Gland Duct Morphogenesis Positive Regulation Of Signal Transduction Epithelial Tube Morphogenesis Cerebellum Morphogenesis Regulation Of Phosphorylation Hindbrain Morphogenesis Gastrulation With Mouth Forming Second Retina Morphogenesis In Camera-type Eye Bone Remodeling Tube Morphogenesis Negative Regulation Of Fat Cell Differentiation Embryonic Camera-type Eye Development Neural Tube Patterning Forebrain Development Cell Differentiation Response To Peptide Hormone Mammary Gland Duct Morphogenesis Regulation Of Phosphorus Metabolic Process Regulation Of Tissue Remodeling Pattern Specification Process Response To Peptide Embryonic Organ Development Gland Development
Tagcloud ?		aberrant aberrantly accessible bcor cd127 contributors covering cxcl14 fzd5 granulocyte hes6 hic1 hypermethylated hypomorphic island itpka leukemic megakaryocyte prdm16 preleukemic progenitors pu publicly robo3 runx1 sca shortage tal1 underscoring