FZD8

Description		frizzled class receptor 8
Image
GO Annotations	Cellular Component	Golgi Apparatus Plasma Membrane Membrane Neuronal Dense Core Vesicle Wnt-Frizzled-LRP5/6 Complex
	Molecular Function	Transmembrane Signaling Receptor Activity G Protein-coupled Receptor Activity Signaling Receptor Binding Protein Binding Wnt-protein Binding PDZ Domain Binding Ubiquitin Protein Ligase Binding Wnt Receptor Activity
	Biological Process	Angiogenesis Signal Transduction Cell Surface Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Wnt Signaling Pathway Neuron Differentiation T Cell Differentiation In Thymus Non-canonical Wnt Signaling Pathway Canonical Wnt Signaling Pathway
Pathways		Class B/2 (Secretin family receptors) Asymmetric localization of PCP proteins Regulation of FZD by ubiquitination Signaling by RNF43 mutants
Drugs
Diseases
GWAS		Antineutrophil cytoplasmic antibody-associated vasculitis ( 22808956) Diastolic blood pressure x smoking status (current vs non-current) interaction (1df test) ( 29455858) Diastolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Periodontal microbiota ( 22699663) Protein quantitative trait loci ( 18464913)
Novel Interacting Genes		2 novel interacting genes: CUL2 RAE1
Interacting Genes		5 interacting genes: GOPC LRP5 LRP6 RYK WNT1
Entrez ID		8325
HPRD ID		05852
Ensembl ID		ENSG00000177283
Uniprot IDs		Q9H461
PDB IDs		5UN5 5UN6 6NDZ 8X0T
Enriched GO Terms of Interacting Partners?		Midbrain Dopaminergic Neuron Differentiation Wnt Receptor Activity Canonical Wnt Signaling Pathway Wnt-protein Binding Frizzled Binding Dopaminergic Neuron Differentiation Wnt-Frizzled-LRP5/6 Complex Coreceptor Activity Wnt Signaling Pathway Toxin Transmembrane Transporter Activity Wnt Signalosome Central Nervous System Neuron Differentiation Midbrain Development Response To Peptide Hormone Neuron Differentiation Bone Development Midbrain-hindbrain Boundary Maturation During Brain Development Cerebellum Formation Negative Regulation Of Anion Channel Activity Cell-cell Signaling Involved In Mammary Gland Development Chemorepulsion Of Dopaminergic Neuron Axon Positive Regulation Of Cell Proliferation In Midbrain Central Nervous System Morphogenesis Diencephalon Development Neurogenesis Branching Morphogenesis Of An Epithelial Tube Positive Regulation Of Dermatome Development Astrocyte-dopaminergic Neuron Signaling Metencephalon Development Regulation Of Fat Cell Differentiation Cell-cell Signaling Signaling Response To Hormone Morphogenesis Of A Branching Epithelium Norrin Signaling Pathway Forebrain Anterior/posterior Pattern Specification Spemann Organizer Formation Glial Cell-neuron Signaling Midbrain-hindbrain Boundary Development Cell Communication Morphogenesis Of A Branching Structure Anterior/posterior Pattern Specification Mesodermal Cell Migration Apoptotic Process Involved In Blood Vessel Morphogenesis Negative Regulation Of Cell Differentiation Extracellular Matrix-cell Signaling Cell Proliferation In Midbrain Retinal Blood Vessel Morphogenesis Establishment Of Blood-retinal Barrier Chemorepulsion Of Axon
Tagcloud ?